Effect of sugammadex on postoperative complications in patients with severe burn who underwent surgery: a retrospective study
Abstract This retrospective study investigated the association of sugammadex with postoperative pulmonary complication risk between 2013 and 2021 in patients with severe burn of five hospitals. Postoperative pulmonary complications included atelectasis, pulmonary edema, pulmonary effusion, pneumotho...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51171-y |
| _version_ | 1797363382550003712 |
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| author | Jong Ho Kim Minguan Kim Minho Oh Soo-Kyung Lee Young Suk Kwon |
| author_facet | Jong Ho Kim Minguan Kim Minho Oh Soo-Kyung Lee Young Suk Kwon |
| author_sort | Jong Ho Kim |
| collection | DOAJ |
| description | Abstract This retrospective study investigated the association of sugammadex with postoperative pulmonary complication risk between 2013 and 2021 in patients with severe burn of five hospitals. Postoperative pulmonary complications included atelectasis, pulmonary edema, pulmonary effusion, pneumothorax, pneumonia, pulmonary thromboembolism, respiratory failure and acute respiratory distress. To identify whether sugammadex reduced the risk of postoperative pulmonary complication in patients with severe burn who underwent surgery, Kaplan–Meier curve were used to check the difference of incidence according to surgical cases and time-varying Cox hazard regression were used to calculate the hazard ratio. The study included 1213 patients with severe burn who underwent 2259 surgeries. Postoperative pulmonary complications were occurred in 313 (25.8%) patients. Among 2259 surgeries, sugammadex was used in 649 (28.7%) surgeries. Cumulative postoperative pulmonary complication were 268 (16.6%) cases in surgeries without sugammadex, and 45 (6.9%) cases in surgeries with sugammadex, respectively (P < 0.005). The postoperative pulmonary complications risk was reduced significantly in patients who use sugammadex than those who did not use sugammadex. (Adjusted hazard ratio, 0.61; 95% confidence interval, 0.42–0.89; P = 0.011). In conclusion, sugammadex reduced risk of postoperative pulmonary complications compared with nonuse of sugammadex in patients with severe burn who underwent surgery. |
| first_indexed | 2024-03-08T16:20:35Z |
| format | Article |
| id | doaj.art-9284cf5ce34a42e28310a5dcc24dd50e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T16:20:35Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9284cf5ce34a42e28310a5dcc24dd50e2024-01-07T12:23:48ZengNature PortfolioScientific Reports2045-23222024-01-0114111310.1038/s41598-024-51171-yEffect of sugammadex on postoperative complications in patients with severe burn who underwent surgery: a retrospective studyJong Ho Kim0Minguan Kim1Minho Oh2Soo-Kyung Lee3Young Suk Kwon4Department of Anesthesiology and Pain Medicine, College of Medicine, Chuncheon Sacred Heart Hospital, Hallym UniversityDepartment of Anesthesiology and Pain Medicine, College of Medicine, Chuncheon Sacred Heart Hospital, Hallym UniversityDepartment of Anesthesiology and Pain Medicine, College of Medicine, Hallym University Sacred Heart Hospital, Hallym UniversityDepartment of Anesthesiology and Pain Medicine, College of Medicine, Hallym University Sacred Heart Hospital, Hallym UniversityDepartment of Anesthesiology and Pain Medicine, College of Medicine, Chuncheon Sacred Heart Hospital, Hallym UniversityAbstract This retrospective study investigated the association of sugammadex with postoperative pulmonary complication risk between 2013 and 2021 in patients with severe burn of five hospitals. Postoperative pulmonary complications included atelectasis, pulmonary edema, pulmonary effusion, pneumothorax, pneumonia, pulmonary thromboembolism, respiratory failure and acute respiratory distress. To identify whether sugammadex reduced the risk of postoperative pulmonary complication in patients with severe burn who underwent surgery, Kaplan–Meier curve were used to check the difference of incidence according to surgical cases and time-varying Cox hazard regression were used to calculate the hazard ratio. The study included 1213 patients with severe burn who underwent 2259 surgeries. Postoperative pulmonary complications were occurred in 313 (25.8%) patients. Among 2259 surgeries, sugammadex was used in 649 (28.7%) surgeries. Cumulative postoperative pulmonary complication were 268 (16.6%) cases in surgeries without sugammadex, and 45 (6.9%) cases in surgeries with sugammadex, respectively (P < 0.005). The postoperative pulmonary complications risk was reduced significantly in patients who use sugammadex than those who did not use sugammadex. (Adjusted hazard ratio, 0.61; 95% confidence interval, 0.42–0.89; P = 0.011). In conclusion, sugammadex reduced risk of postoperative pulmonary complications compared with nonuse of sugammadex in patients with severe burn who underwent surgery.https://doi.org/10.1038/s41598-024-51171-y |
| spellingShingle | Jong Ho Kim Minguan Kim Minho Oh Soo-Kyung Lee Young Suk Kwon Effect of sugammadex on postoperative complications in patients with severe burn who underwent surgery: a retrospective study Scientific Reports |
| title | Effect of sugammadex on postoperative complications in patients with severe burn who underwent surgery: a retrospective study |
| title_full | Effect of sugammadex on postoperative complications in patients with severe burn who underwent surgery: a retrospective study |
| title_fullStr | Effect of sugammadex on postoperative complications in patients with severe burn who underwent surgery: a retrospective study |
| title_full_unstemmed | Effect of sugammadex on postoperative complications in patients with severe burn who underwent surgery: a retrospective study |
| title_short | Effect of sugammadex on postoperative complications in patients with severe burn who underwent surgery: a retrospective study |
| title_sort | effect of sugammadex on postoperative complications in patients with severe burn who underwent surgery a retrospective study |
| url | https://doi.org/10.1038/s41598-024-51171-y |
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