Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors

Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors

Invasive fungal infections (IFIs) have been associated with high mortality, highlighting the urgent need for developing novel antifungal strategies. Herein the first light-responsive antifungal agents were designed by optical control of fungal ergosterol biosynthesis pathway with photocaged triazole...

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Bibliographic Details
Main Authors:	Zhuang Li, Na Liu, Wanzhen Yang, Jie Tu, Yahui Huang, Wei Wang, Chunquan Sheng
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Antifungal agents Ergosterol biosynthesis Triazoles Photocaged Optical control
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383523000552

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