Reversible Complete Heart Block in a Pregnant Woman Related to Sertraline TreatmentNovel Teaching Points
Complete heart block (CHB) is a serious condition, usually affecting older patients. We report a case of CHB in a 31-year-old pregnant woman treated with sertraline in whom atrioventricular (AV) conduction normalized after discontinuation of sertraline. Results of subsequent genetic investigations f...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | CJC Open |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589790X21002638 |
| _version_ | 1828891904464388096 |
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| author | Frederik Cosedis Enevoldsen, MBBS Jens Cosedis Nielsen, MD, PhD, DMSc Torsten Bloch Rasmussen, MD, PhD |
| author_facet | Frederik Cosedis Enevoldsen, MBBS Jens Cosedis Nielsen, MD, PhD, DMSc Torsten Bloch Rasmussen, MD, PhD |
| author_sort | Frederik Cosedis Enevoldsen, MBBS |
| collection | DOAJ |
| description | Complete heart block (CHB) is a serious condition, usually affecting older patients. We report a case of CHB in a 31-year-old pregnant woman treated with sertraline in whom atrioventricular (AV) conduction normalized after discontinuation of sertraline. Results of subsequent genetic investigations for inherited cardiomyopathy and ion-channel disease and a pharmacogenetic study of sertraline pharmacokinetics were negative. Reversible CHB in this younger pregnant patient was temporally related to sertraline. This case underlines the importance of identifying reversible causes when a young patient presents with AV block with unknown trajectory and prognosis, as well as regular recording of electrocardiograms in pregnant patients on psychotropic medications. Résumé: Le bloc cardiaque complet (BCC) est une affection sérieuse, qui touche généralement les patients âgés. Nous présentons un cas de BCC chez une femme enceinte de 31 ans traitée par sertraline chez qui la normalisation de la conduction atrioventriculaire (AV) a été constatée après l’arrêt de la sertraline. Les résultats des examens génétiques subséquents de cardiomyopathie héréditaire et de maladies des canaux ioniques, et d’une étude pharmacogénétique de la pharmacocinétique de la sertraline étaient négatifs. LE BCC réversible chez cette jeune patiente enceinte était temporairement lié à la sertraline. Ce cas montre l’importance de cerner les causes réversibles lorsqu’un jeune patient présente un bloc AV à la trajectoire et au pronostic inconnus, et de faire régulièrement des électrocardiogrammes chez les patientes enceintes qui prennent des psychotropes. |
| first_indexed | 2024-12-13T13:25:18Z |
| format | Article |
| id | doaj.art-9286f888a0364fb3b663e1d8d759a8d0 |
| institution | Directory Open Access Journal |
| issn | 2589-790X |
| language | English |
| last_indexed | 2024-12-13T13:25:18Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | CJC Open |
| spelling | doaj.art-9286f888a0364fb3b663e1d8d759a8d02022-12-21T23:44:18ZengElsevierCJC Open2589-790X2022-02-0142240242Reversible Complete Heart Block in a Pregnant Woman Related to Sertraline TreatmentNovel Teaching PointsFrederik Cosedis Enevoldsen, MBBS0Jens Cosedis Nielsen, MD, PhD, DMSc1Torsten Bloch Rasmussen, MD, PhD2Department of Cardiology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Corresponding author: Dr Jens Cosedis Nielsen, Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200, Aarhus N, Denmark. Tel.: +45 7845 2039; fax: +45 7845 2118.Department of Cardiology, Aarhus University Hospital, Aarhus, DenmarkComplete heart block (CHB) is a serious condition, usually affecting older patients. We report a case of CHB in a 31-year-old pregnant woman treated with sertraline in whom atrioventricular (AV) conduction normalized after discontinuation of sertraline. Results of subsequent genetic investigations for inherited cardiomyopathy and ion-channel disease and a pharmacogenetic study of sertraline pharmacokinetics were negative. Reversible CHB in this younger pregnant patient was temporally related to sertraline. This case underlines the importance of identifying reversible causes when a young patient presents with AV block with unknown trajectory and prognosis, as well as regular recording of electrocardiograms in pregnant patients on psychotropic medications. Résumé: Le bloc cardiaque complet (BCC) est une affection sérieuse, qui touche généralement les patients âgés. Nous présentons un cas de BCC chez une femme enceinte de 31 ans traitée par sertraline chez qui la normalisation de la conduction atrioventriculaire (AV) a été constatée après l’arrêt de la sertraline. Les résultats des examens génétiques subséquents de cardiomyopathie héréditaire et de maladies des canaux ioniques, et d’une étude pharmacogénétique de la pharmacocinétique de la sertraline étaient négatifs. LE BCC réversible chez cette jeune patiente enceinte était temporairement lié à la sertraline. Ce cas montre l’importance de cerner les causes réversibles lorsqu’un jeune patient présente un bloc AV à la trajectoire et au pronostic inconnus, et de faire régulièrement des électrocardiogrammes chez les patientes enceintes qui prennent des psychotropes.http://www.sciencedirect.com/science/article/pii/S2589790X21002638 |
| spellingShingle | Frederik Cosedis Enevoldsen, MBBS Jens Cosedis Nielsen, MD, PhD, DMSc Torsten Bloch Rasmussen, MD, PhD Reversible Complete Heart Block in a Pregnant Woman Related to Sertraline TreatmentNovel Teaching Points CJC Open |
| title | Reversible Complete Heart Block in a Pregnant Woman Related to Sertraline TreatmentNovel Teaching Points |
| title_full | Reversible Complete Heart Block in a Pregnant Woman Related to Sertraline TreatmentNovel Teaching Points |
| title_fullStr | Reversible Complete Heart Block in a Pregnant Woman Related to Sertraline TreatmentNovel Teaching Points |
| title_full_unstemmed | Reversible Complete Heart Block in a Pregnant Woman Related to Sertraline TreatmentNovel Teaching Points |
| title_short | Reversible Complete Heart Block in a Pregnant Woman Related to Sertraline TreatmentNovel Teaching Points |
| title_sort | reversible complete heart block in a pregnant woman related to sertraline treatmentnovel teaching points |
| url | http://www.sciencedirect.com/science/article/pii/S2589790X21002638 |
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