Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer
Summary: Recent studies have begun to highlight the diverse and tumor-specific microbiomes across multiple cancer types. We believe this work raises the important question of whether the classical “Hallmarks of Cancer” should be expanded to include tumor microbiomes. To answer this question, the cau...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-12-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220310750 |
| _version_ | 1819143005296132096 |
|---|---|
| author | Barath Udayasuryan Tam T.D. Nguyen Daniel J. Slade Scott S. Verbridge |
| author_facet | Barath Udayasuryan Tam T.D. Nguyen Daniel J. Slade Scott S. Verbridge |
| author_sort | Barath Udayasuryan |
| collection | DOAJ |
| description | Summary: Recent studies have begun to highlight the diverse and tumor-specific microbiomes across multiple cancer types. We believe this work raises the important question of whether the classical “Hallmarks of Cancer” should be expanded to include tumor microbiomes. To answer this question, the causal relationships and co-evolution of these microbiotic tumor ecosystems must be better understood. Because host-microbe interactions should be studied in a physiologically relevant context, animal models have been preferred. Yet these models are often poor mimics of human tumors and are difficult to interrogate at high spatiotemporal resolution. We believe that in vitro tissue engineered platforms could provide a powerful alternative approach that combines the high-resolution of in vitro studies with a high degree of physiological relevance. This review will focus on tissue engineered approaches to study host-microbe interactions and to establish their role as an emerging hallmark of cancer with potential as a therapeutic target. |
| first_indexed | 2024-12-22T12:19:22Z |
| format | Article |
| id | doaj.art-9288e4e1bfb64fd18e575d04d0ddba0f |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-22T12:19:22Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-9288e4e1bfb64fd18e575d04d0ddba0f2022-12-21T18:26:03ZengElsevieriScience2589-00422020-12-012312101878Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in CancerBarath Udayasuryan0Tam T.D. Nguyen1Daniel J. Slade2Scott S. Verbridge3Virginia Tech – Wake Forest School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USADepartment of Biochemistry, Virginia Polytechnic and State University, Blacksburg, VA 24061, USADepartment of Biochemistry, Virginia Polytechnic and State University, Blacksburg, VA 24061, USAVirginia Tech – Wake Forest School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA; Corresponding authorSummary: Recent studies have begun to highlight the diverse and tumor-specific microbiomes across multiple cancer types. We believe this work raises the important question of whether the classical “Hallmarks of Cancer” should be expanded to include tumor microbiomes. To answer this question, the causal relationships and co-evolution of these microbiotic tumor ecosystems must be better understood. Because host-microbe interactions should be studied in a physiologically relevant context, animal models have been preferred. Yet these models are often poor mimics of human tumors and are difficult to interrogate at high spatiotemporal resolution. We believe that in vitro tissue engineered platforms could provide a powerful alternative approach that combines the high-resolution of in vitro studies with a high degree of physiological relevance. This review will focus on tissue engineered approaches to study host-microbe interactions and to establish their role as an emerging hallmark of cancer with potential as a therapeutic target.http://www.sciencedirect.com/science/article/pii/S2589004220310750MicrobiomeBioengineeringTissue EngineeringCancer |
| spellingShingle | Barath Udayasuryan Tam T.D. Nguyen Daniel J. Slade Scott S. Verbridge Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer iScience Microbiome Bioengineering Tissue Engineering Cancer |
| title | Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer |
| title_full | Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer |
| title_fullStr | Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer |
| title_full_unstemmed | Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer |
| title_short | Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer |
| title_sort | harnessing tissue engineering tools to interrogate host microbiota crosstalk in cancer |
| topic | Microbiome Bioengineering Tissue Engineering Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220310750 |
| work_keys_str_mv | AT barathudayasuryan harnessingtissueengineeringtoolstointerrogatehostmicrobiotacrosstalkincancer AT tamtdnguyen harnessingtissueengineeringtoolstointerrogatehostmicrobiotacrosstalkincancer AT danieljslade harnessingtissueengineeringtoolstointerrogatehostmicrobiotacrosstalkincancer AT scottsverbridge harnessingtissueengineeringtoolstointerrogatehostmicrobiotacrosstalkincancer |