Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit
Summary: The lateral entorhinal cortex (LEC) provides multisensory information to the hippocampus, directly to the distal dendrites of CA1 pyramidal neurons. LEC neurons perform important functions for episodic memory processing, coding for contextually salient elements of an environment or experien...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124722018666 |
| _version_ | 1797961217835270144 |
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| author | Olesia M. Bilash Spyridon Chavlis Cara D. Johnson Panayiota Poirazi Jayeeta Basu |
| author_facet | Olesia M. Bilash Spyridon Chavlis Cara D. Johnson Panayiota Poirazi Jayeeta Basu |
| author_sort | Olesia M. Bilash |
| collection | DOAJ |
| description | Summary: The lateral entorhinal cortex (LEC) provides multisensory information to the hippocampus, directly to the distal dendrites of CA1 pyramidal neurons. LEC neurons perform important functions for episodic memory processing, coding for contextually salient elements of an environment or experience. However, we know little about the functional circuit interactions between the LEC and the hippocampus. We combine functional circuit mapping and computational modeling to examine how long-range glutamatergic LEC projections modulate compartment-specific excitation-inhibition dynamics in hippocampal area CA1. We demonstrate that glutamatergic LEC inputs can drive local dendritic spikes in CA1 pyramidal neurons, aided by the recruitment of a disinhibitory VIP interneuron microcircuit. Our circuit mapping and modeling further reveal that LEC inputs also recruit CCK interneurons that may act as strong suppressors of dendritic spikes. These results highlight a cortically driven GABAergic microcircuit mechanism that gates nonlinear dendritic computations, which may support compartment-specific coding of multisensory contextual features within the hippocampus. |
| first_indexed | 2024-04-11T00:55:37Z |
| format | Article |
| id | doaj.art-9289c25201c94f46a68fff828d208029 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-11T00:55:37Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-9289c25201c94f46a68fff828d2080292023-01-05T04:31:59ZengElsevierCell Reports2211-12472023-01-01421111962Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuitOlesia M. Bilash0Spyridon Chavlis1Cara D. Johnson2Panayiota Poirazi3Jayeeta Basu4Neuroscience Institute, Department of Neuroscience and Physiology, New York University Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USAInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete 70013, GreeceNeuroscience Institute, Department of Neuroscience and Physiology, New York University Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USAInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete 70013, Greece; Corresponding authorNeuroscience Institute, Department of Neuroscience and Physiology, New York University Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA; Department of Psychiatry, New York University Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USA; Corresponding authorSummary: The lateral entorhinal cortex (LEC) provides multisensory information to the hippocampus, directly to the distal dendrites of CA1 pyramidal neurons. LEC neurons perform important functions for episodic memory processing, coding for contextually salient elements of an environment or experience. However, we know little about the functional circuit interactions between the LEC and the hippocampus. We combine functional circuit mapping and computational modeling to examine how long-range glutamatergic LEC projections modulate compartment-specific excitation-inhibition dynamics in hippocampal area CA1. We demonstrate that glutamatergic LEC inputs can drive local dendritic spikes in CA1 pyramidal neurons, aided by the recruitment of a disinhibitory VIP interneuron microcircuit. Our circuit mapping and modeling further reveal that LEC inputs also recruit CCK interneurons that may act as strong suppressors of dendritic spikes. These results highlight a cortically driven GABAergic microcircuit mechanism that gates nonlinear dendritic computations, which may support compartment-specific coding of multisensory contextual features within the hippocampus.http://www.sciencedirect.com/science/article/pii/S2211124722018666CP: Neuroscience |
| spellingShingle | Olesia M. Bilash Spyridon Chavlis Cara D. Johnson Panayiota Poirazi Jayeeta Basu Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit Cell Reports CP: Neuroscience |
| title | Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit |
| title_full | Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit |
| title_fullStr | Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit |
| title_full_unstemmed | Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit |
| title_short | Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit |
| title_sort | lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124722018666 |
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