Differentiation and management of hepatobiliary mucinous cystic neoplasms: a single centre experience for 8 years
Abstract Background Hepatobiliary mucinous cystic neoplasms (H-MCNs) are relatively rare cystic neoplasms in the liver. The differential diagnosis of H-MCNs remains big challenging, and the management and prognosis between the hepatic simple cyst (HSC) and H-MCNs are quite different. This study aime...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-021-01110-9 |
| _version_ | 1818677608585363456 |
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| author | Jiaqi Gao Junhao Zheng Jingwei Cai Mubarak Ali Kirih Junjie Xu Liye Tao Yuelong Liang Xu Feng Jing Fang Xiao Liang |
| author_facet | Jiaqi Gao Junhao Zheng Jingwei Cai Mubarak Ali Kirih Junjie Xu Liye Tao Yuelong Liang Xu Feng Jing Fang Xiao Liang |
| author_sort | Jiaqi Gao |
| collection | DOAJ |
| description | Abstract Background Hepatobiliary mucinous cystic neoplasms (H-MCNs) are relatively rare cystic neoplasms in the liver. The differential diagnosis of H-MCNs remains big challenging, and the management and prognosis between the hepatic simple cyst (HSC) and H-MCNs are quite different. This study aimed to present our experience in the management of H-MCNs and provide a preoperative H-MCNs risk prediction nomogram to differentiating H-MCNs from liver cystic lesions. Methods 29 patients diagnosed with H-MCNs and 75 patients diagnosed with HSC between June 2011 and June 2019 at Zhejiang University School of medicine, Sir Run-Run Shaw Hospital were reviewed in this study. We analyzed the demographic and clinicopathological variables. Results US, CT, and MRI could accurately diagnose only 3.4%, 46.1%, and 57.1% of H-MCNs, respectively. After univariate analysis and multivariate logistic regression analysis, the variables significantly associated with H-MCNs were enhancement after contrast (p = 0.009), tumour located in the left lobe (p = 0.02) and biliary ductal dilation (p = 0.027). An H-MCNs risk predictive nomogram was constructed, which showed excellent discrimination (areas under the receiver operating characteristic curve were 0.940) and consistent calibration between the predicted probability and actual probability. Conclusion Among patients with H-MCNs, the location of the tumour, enhancement in CT scan, and biliary duct dilation are significantly independent risk factors. The appropriate treatment of H-MCNs is radical resection. Using our Nomogram could facilitate screening and identification of patients with liver cystic lesions. |
| first_indexed | 2024-12-17T09:02:05Z |
| format | Article |
| id | doaj.art-9289e19eebeb4da6a14d8d091a8f587c |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-12-17T09:02:05Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-9289e19eebeb4da6a14d8d091a8f587c2022-12-21T21:55:40ZengBMCBMC Surgery1471-24822021-03-012111910.1186/s12893-021-01110-9Differentiation and management of hepatobiliary mucinous cystic neoplasms: a single centre experience for 8 yearsJiaqi Gao0Junhao Zheng1Jingwei Cai2Mubarak Ali Kirih3Junjie Xu4Liye Tao5Yuelong Liang6Xu Feng7Jing Fang8Xiao Liang9Department of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityAbstract Background Hepatobiliary mucinous cystic neoplasms (H-MCNs) are relatively rare cystic neoplasms in the liver. The differential diagnosis of H-MCNs remains big challenging, and the management and prognosis between the hepatic simple cyst (HSC) and H-MCNs are quite different. This study aimed to present our experience in the management of H-MCNs and provide a preoperative H-MCNs risk prediction nomogram to differentiating H-MCNs from liver cystic lesions. Methods 29 patients diagnosed with H-MCNs and 75 patients diagnosed with HSC between June 2011 and June 2019 at Zhejiang University School of medicine, Sir Run-Run Shaw Hospital were reviewed in this study. We analyzed the demographic and clinicopathological variables. Results US, CT, and MRI could accurately diagnose only 3.4%, 46.1%, and 57.1% of H-MCNs, respectively. After univariate analysis and multivariate logistic regression analysis, the variables significantly associated with H-MCNs were enhancement after contrast (p = 0.009), tumour located in the left lobe (p = 0.02) and biliary ductal dilation (p = 0.027). An H-MCNs risk predictive nomogram was constructed, which showed excellent discrimination (areas under the receiver operating characteristic curve were 0.940) and consistent calibration between the predicted probability and actual probability. Conclusion Among patients with H-MCNs, the location of the tumour, enhancement in CT scan, and biliary duct dilation are significantly independent risk factors. The appropriate treatment of H-MCNs is radical resection. Using our Nomogram could facilitate screening and identification of patients with liver cystic lesions.https://doi.org/10.1186/s12893-021-01110-9CystadenomaLiverDiagnosisSurgical procedures |
| spellingShingle | Jiaqi Gao Junhao Zheng Jingwei Cai Mubarak Ali Kirih Junjie Xu Liye Tao Yuelong Liang Xu Feng Jing Fang Xiao Liang Differentiation and management of hepatobiliary mucinous cystic neoplasms: a single centre experience for 8 years BMC Surgery Cystadenoma Liver Diagnosis Surgical procedures |
| title | Differentiation and management of hepatobiliary mucinous cystic neoplasms: a single centre experience for 8 years |
| title_full | Differentiation and management of hepatobiliary mucinous cystic neoplasms: a single centre experience for 8 years |
| title_fullStr | Differentiation and management of hepatobiliary mucinous cystic neoplasms: a single centre experience for 8 years |
| title_full_unstemmed | Differentiation and management of hepatobiliary mucinous cystic neoplasms: a single centre experience for 8 years |
| title_short | Differentiation and management of hepatobiliary mucinous cystic neoplasms: a single centre experience for 8 years |
| title_sort | differentiation and management of hepatobiliary mucinous cystic neoplasms a single centre experience for 8 years |
| topic | Cystadenoma Liver Diagnosis Surgical procedures |
| url | https://doi.org/10.1186/s12893-021-01110-9 |
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