Zinc in Prostate Health and Disease: A Mini Review
<b>Introduction</b>-With the high global prevalence of prostate cancer and associated mortalities, it is important to enhance current clinical practices for better prostate cancer outcomes. The current review is towards understanding the value of Zn towards this mission. <b>Method&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/12/3206 |
| _version_ | 1797461303713857536 |
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| author | Nishi Karunasinghe |
| author_facet | Nishi Karunasinghe |
| author_sort | Nishi Karunasinghe |
| collection | DOAJ |
| description | <b>Introduction</b>-With the high global prevalence of prostate cancer and associated mortalities, it is important to enhance current clinical practices for better prostate cancer outcomes. The current review is towards understanding the value of Zn towards this mission. <b>Method</b>-General information on Zn in biology and multiple aspects of Zn involvement in prostate health and disease were referred to in PubMed. <b>Results</b>-The most influential feature of Zn towards prostate health is its ability to retain sufficient citrate levels for a healthy prostate. Zn deficiencies were recorded in serum, hair, and prostate tissue of men with prostate cancer compared to non-cancer controls. Zn gut absorption, albumin binding, and storage compete with various factors. There are multiple associations of Zn cellular influx and efflux transporters, Zn finger proteins, matrix metalloproteinases, and Zn signaling with prostate cancer outcomes. Such Zn marker variations associated with prostate cancer recorded from biological matrices may improve algorithms for prostate cancer screening, prognosis, and management when coupled with standard clinical practices. <b>Discussion</b>-The influence of Zn in prostatic health and disease is multidimensional, therefore more personalized Zn requirements may be beneficial. Several opportunities exist to utilize and improve understanding of Zn associations with prostate health and disease. |
| first_indexed | 2024-03-09T17:18:24Z |
| format | Article |
| id | doaj.art-928b2e4ad2794626b4683eea726d2862 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:18:24Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-928b2e4ad2794626b4683eea726d28622023-11-24T13:28:41ZengMDPI AGBiomedicines2227-90592022-12-011012320610.3390/biomedicines10123206Zinc in Prostate Health and Disease: A Mini ReviewNishi Karunasinghe0Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand<b>Introduction</b>-With the high global prevalence of prostate cancer and associated mortalities, it is important to enhance current clinical practices for better prostate cancer outcomes. The current review is towards understanding the value of Zn towards this mission. <b>Method</b>-General information on Zn in biology and multiple aspects of Zn involvement in prostate health and disease were referred to in PubMed. <b>Results</b>-The most influential feature of Zn towards prostate health is its ability to retain sufficient citrate levels for a healthy prostate. Zn deficiencies were recorded in serum, hair, and prostate tissue of men with prostate cancer compared to non-cancer controls. Zn gut absorption, albumin binding, and storage compete with various factors. There are multiple associations of Zn cellular influx and efflux transporters, Zn finger proteins, matrix metalloproteinases, and Zn signaling with prostate cancer outcomes. Such Zn marker variations associated with prostate cancer recorded from biological matrices may improve algorithms for prostate cancer screening, prognosis, and management when coupled with standard clinical practices. <b>Discussion</b>-The influence of Zn in prostatic health and disease is multidimensional, therefore more personalized Zn requirements may be beneficial. Several opportunities exist to utilize and improve understanding of Zn associations with prostate health and disease.https://www.mdpi.com/2227-9059/10/12/3206Zinc (Zn)prostatecitrateZn transportersmetallothioninesmatrix metalloproteinases |
| spellingShingle | Nishi Karunasinghe Zinc in Prostate Health and Disease: A Mini Review Biomedicines Zinc (Zn) prostate citrate Zn transporters metallothionines matrix metalloproteinases |
| title | Zinc in Prostate Health and Disease: A Mini Review |
| title_full | Zinc in Prostate Health and Disease: A Mini Review |
| title_fullStr | Zinc in Prostate Health and Disease: A Mini Review |
| title_full_unstemmed | Zinc in Prostate Health and Disease: A Mini Review |
| title_short | Zinc in Prostate Health and Disease: A Mini Review |
| title_sort | zinc in prostate health and disease a mini review |
| topic | Zinc (Zn) prostate citrate Zn transporters metallothionines matrix metalloproteinases |
| url | https://www.mdpi.com/2227-9059/10/12/3206 |
| work_keys_str_mv | AT nishikarunasinghe zincinprostatehealthanddiseaseaminireview |