Antifungal effects of alantolactone on Candida albicans: An in vitro study
The human fungal pathogen Candida albicans can cause many kinds of infections, including biofilm infections on medical devices, while the available antifungal drugs are limited to only a few. In this study, alantolactone (Ala) demonstrated antifungal activities against C. albicans, as well as other...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222002025 |
| _version_ | 1811299559479967744 |
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| author | Longfei Yang Lili Zhong Zhiming Ma Yujie Sui Jia’nan Xie Xin Liu Tonghui Ma |
| author_facet | Longfei Yang Lili Zhong Zhiming Ma Yujie Sui Jia’nan Xie Xin Liu Tonghui Ma |
| author_sort | Longfei Yang |
| collection | DOAJ |
| description | The human fungal pathogen Candida albicans can cause many kinds of infections, including biofilm infections on medical devices, while the available antifungal drugs are limited to only a few. In this study, alantolactone (Ala) demonstrated antifungal activities against C. albicans, as well as other Candida species, with a MIC of 72 μg/mL. Ala could also inhibit the adhesion, yeast-to-hyphal transition, biofilm formation and development of C. albicans. The exopolysaccharide of biofilm matrix and extracellular phospholipase production could also be reduced by Ala treatment. Ala could increase permeability of C. albicans cell membrane and ROS contribute to the anti-biofilm activity of Ala. Overall, the present study suggests that Ala may provide a promising candidate for developing antifungal drugs against C. albicans infections. |
| first_indexed | 2024-04-13T06:36:40Z |
| format | Article |
| id | doaj.art-928bb2d2d9ee478da46985ae76f2d2f0 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T06:36:40Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-928bb2d2d9ee478da46985ae76f2d2f02022-12-22T02:57:52ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-05-01149112814Antifungal effects of alantolactone on Candida albicans: An in vitro studyLongfei Yang0Lili Zhong1Zhiming Ma2Yujie Sui3Jia’nan Xie4Xin Liu5Tonghui Ma6Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, ChinaEye Center, The Second Hospital of Jilin University, Changchun 130024, ChinaEye Center, The Second Hospital of Jilin University, Changchun 130024, China; Corresponding authors.Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, China; Corresponding authors.The human fungal pathogen Candida albicans can cause many kinds of infections, including biofilm infections on medical devices, while the available antifungal drugs are limited to only a few. In this study, alantolactone (Ala) demonstrated antifungal activities against C. albicans, as well as other Candida species, with a MIC of 72 μg/mL. Ala could also inhibit the adhesion, yeast-to-hyphal transition, biofilm formation and development of C. albicans. The exopolysaccharide of biofilm matrix and extracellular phospholipase production could also be reduced by Ala treatment. Ala could increase permeability of C. albicans cell membrane and ROS contribute to the anti-biofilm activity of Ala. Overall, the present study suggests that Ala may provide a promising candidate for developing antifungal drugs against C. albicans infections.http://www.sciencedirect.com/science/article/pii/S0753332222002025Candida albicansAlantolactoneAntifungalVirulence factorBiofilmReactive oxygen species (ROS) |
| spellingShingle | Longfei Yang Lili Zhong Zhiming Ma Yujie Sui Jia’nan Xie Xin Liu Tonghui Ma Antifungal effects of alantolactone on Candida albicans: An in vitro study Biomedicine & Pharmacotherapy Candida albicans Alantolactone Antifungal Virulence factor Biofilm Reactive oxygen species (ROS) |
| title | Antifungal effects of alantolactone on Candida albicans: An in vitro study |
| title_full | Antifungal effects of alantolactone on Candida albicans: An in vitro study |
| title_fullStr | Antifungal effects of alantolactone on Candida albicans: An in vitro study |
| title_full_unstemmed | Antifungal effects of alantolactone on Candida albicans: An in vitro study |
| title_short | Antifungal effects of alantolactone on Candida albicans: An in vitro study |
| title_sort | antifungal effects of alantolactone on candida albicans an in vitro study |
| topic | Candida albicans Alantolactone Antifungal Virulence factor Biofilm Reactive oxygen species (ROS) |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222002025 |
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