MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL MANIFESTATIONS OF DIFFERENT VARIANTS OF ACUTE KIDNEY ALLOGRAFT REJECTION
The aim of this study was morphological characteristics of peculiar properties of acute T-cells- (ATMR) and antibody-mediated kidney allograft rejection (AAMR). Histological slices of kidney allograft biopsies were examined after coloration by routine methods and immunohistochemical proceeding for C...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2009-05-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/179 |
| _version_ | 1797872154958626816 |
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| author | A.V Trailin T.N. Nikonenko T.I. Ostapenko N.N. Polyakov A.S. Nikonenko |
| author_facet | A.V Trailin T.N. Nikonenko T.I. Ostapenko N.N. Polyakov A.S. Nikonenko |
| author_sort | A.V Trailin |
| collection | DOAJ |
| description | The aim of this study was morphological characteristics of peculiar properties of acute T-cells- (ATMR) and antibody-mediated kidney allograft rejection (AAMR). Histological slices of kidney allograft biopsies were examined after coloration by routine methods and immunohistochemical proceeding for C4d, CD45R0 T-lymphocytes antigen and CD68 macrophages antigen. We’ve determined that the key features of ATMR are: increasing of T-lymphocytes interstitial infi ltration with the same level of macrophages infi ltration comparing with implantation biopsies, mild mononuclear glomerulitis and capillaritis; tubulitis. Morphological traits of AAMR are neutrophilic and T-lymphocytes glomerulitis, diffuse capillaritis, capillaries dilatation and margination of mononuclear cells with admixture of neutrophils, macrophagal interstitial infi ltration under semiquantitative evaluation, as well as, more pronounced, than in ATMR, T-lymphoctes and macrophages interstitial infi ltration under quantitative evaluation. |
| first_indexed | 2024-04-10T00:55:15Z |
| format | Article |
| id | doaj.art-928db872908b40ec977de81ef73dc211 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:55:15Z |
| publishDate | 2009-05-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-928db872908b40ec977de81ef73dc2112023-03-13T10:37:17ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912009-05-01112293610.15825/1995-1191-2009-2-29-36122MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL MANIFESTATIONS OF DIFFERENT VARIANTS OF ACUTE KIDNEY ALLOGRAFT REJECTIONA.V Trailin0T.N. Nikonenko1T.I. Ostapenko2N.N. Polyakov3A.S. Nikonenko4Zaporozhskaya medical academy of postgraduate education, UkrainaZaporozhskaya medical academy of postgraduate education, UkrainaZaporozhsky interregional transplant center, UkrainaZaporozhsky interregional transplant center, Ukraina Zaporozhskaya medical academy of postgraduate education, UkrainaZaporozhsky interregional transplant center, Ukraina Zaporozhskaya medical academy of postgraduate education, UkrainaThe aim of this study was morphological characteristics of peculiar properties of acute T-cells- (ATMR) and antibody-mediated kidney allograft rejection (AAMR). Histological slices of kidney allograft biopsies were examined after coloration by routine methods and immunohistochemical proceeding for C4d, CD45R0 T-lymphocytes antigen and CD68 macrophages antigen. We’ve determined that the key features of ATMR are: increasing of T-lymphocytes interstitial infi ltration with the same level of macrophages infi ltration comparing with implantation biopsies, mild mononuclear glomerulitis and capillaritis; tubulitis. Morphological traits of AAMR are neutrophilic and T-lymphocytes glomerulitis, diffuse capillaritis, capillaries dilatation and margination of mononuclear cells with admixture of neutrophils, macrophagal interstitial infi ltration under semiquantitative evaluation, as well as, more pronounced, than in ATMR, T-lymphoctes and macrophages interstitial infi ltration under quantitative evaluation.https://journal.transpl.ru/vtio/article/view/179kidney transplantation, acute rejection, c4d |
| spellingShingle | A.V Trailin T.N. Nikonenko T.I. Ostapenko N.N. Polyakov A.S. Nikonenko MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL MANIFESTATIONS OF DIFFERENT VARIANTS OF ACUTE KIDNEY ALLOGRAFT REJECTION Vestnik Transplantologii i Iskusstvennyh Organov kidney transplantation, acute rejection, c4d |
| title | MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL MANIFESTATIONS OF DIFFERENT VARIANTS OF ACUTE KIDNEY ALLOGRAFT REJECTION |
| title_full | MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL MANIFESTATIONS OF DIFFERENT VARIANTS OF ACUTE KIDNEY ALLOGRAFT REJECTION |
| title_fullStr | MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL MANIFESTATIONS OF DIFFERENT VARIANTS OF ACUTE KIDNEY ALLOGRAFT REJECTION |
| title_full_unstemmed | MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL MANIFESTATIONS OF DIFFERENT VARIANTS OF ACUTE KIDNEY ALLOGRAFT REJECTION |
| title_short | MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL MANIFESTATIONS OF DIFFERENT VARIANTS OF ACUTE KIDNEY ALLOGRAFT REJECTION |
| title_sort | morphological and immunohistochemical manifestations of different variants of acute kidney allograft rejection |
| topic | kidney transplantation, acute rejection, c4d |
| url | https://journal.transpl.ru/vtio/article/view/179 |
| work_keys_str_mv | AT avtrailin morphologicalandimmunohistochemicalmanifestationsofdifferentvariantsofacutekidneyallograftrejection AT tnnikonenko morphologicalandimmunohistochemicalmanifestationsofdifferentvariantsofacutekidneyallograftrejection AT tiostapenko morphologicalandimmunohistochemicalmanifestationsofdifferentvariantsofacutekidneyallograftrejection AT nnpolyakov morphologicalandimmunohistochemicalmanifestationsofdifferentvariantsofacutekidneyallograftrejection AT asnikonenko morphologicalandimmunohistochemicalmanifestationsofdifferentvariantsofacutekidneyallograftrejection |