Bioactivity of boronic acid derivative homodimers
Homodimers that deployed boronic acids and their esters in their termini, namely boronic acid derivative homodimers, were designed. The boronic acid pinacol ester homodimer displayed antiviral activity and the boronic acid homodimer, in contrast, exerted cytotoxicity. Chemical modification of the bo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622002788 |
| _version_ | 1811178064384622592 |
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| author | Kaori Ota Jian-Rong Zhou Kazumi Yokomizo Tomohiro Kozako Shin-ichiro Honda Nobuhiro Kashige Makoto Furutachi Kunihiro Sumoto |
| author_facet | Kaori Ota Jian-Rong Zhou Kazumi Yokomizo Tomohiro Kozako Shin-ichiro Honda Nobuhiro Kashige Makoto Furutachi Kunihiro Sumoto |
| author_sort | Kaori Ota |
| collection | DOAJ |
| description | Homodimers that deployed boronic acids and their esters in their termini, namely boronic acid derivative homodimers, were designed. The boronic acid pinacol ester homodimer displayed antiviral activity and the boronic acid homodimer, in contrast, exerted cytotoxicity. Chemical modification of the boronic acid pinacol ester homodimers revealed that most of their derivatives showed an antiviral tendency as did their lead compounds albeit the same or worse antiviral activity. In contrast, chemical modification of the boronic acid homodimer revealed that most of its derivatives unexpectedly showed antibacterial and antiviral tendencies unlike their lead compound. The boronic acid homodimer also exerted antiproliferative activity against leukemic cell lines. The results of this study provided an insight into hitherto-unprecedented boronic acid and its pinacol ester homodimers as bioactive agents. |
| first_indexed | 2024-04-11T06:13:09Z |
| format | Article |
| id | doaj.art-928eb1bab9ef42b4b0d8fdd2018a5cdf |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-11T06:13:09Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-928eb1bab9ef42b4b0d8fdd2018a5cdf2022-12-22T04:41:09ZengElsevierResults in Chemistry2211-71562022-01-014100559Bioactivity of boronic acid derivative homodimersKaori Ota0Jian-Rong Zhou1Kazumi Yokomizo2Tomohiro Kozako3Shin-ichiro Honda4Nobuhiro Kashige5Makoto Furutachi6Kunihiro Sumoto7Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanFaculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, JapanFaculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, JapanFaculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanFaculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanFaculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanFaculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan; Corresponding author.Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanHomodimers that deployed boronic acids and their esters in their termini, namely boronic acid derivative homodimers, were designed. The boronic acid pinacol ester homodimer displayed antiviral activity and the boronic acid homodimer, in contrast, exerted cytotoxicity. Chemical modification of the boronic acid pinacol ester homodimers revealed that most of their derivatives showed an antiviral tendency as did their lead compounds albeit the same or worse antiviral activity. In contrast, chemical modification of the boronic acid homodimer revealed that most of its derivatives unexpectedly showed antibacterial and antiviral tendencies unlike their lead compound. The boronic acid homodimer also exerted antiproliferative activity against leukemic cell lines. The results of this study provided an insight into hitherto-unprecedented boronic acid and its pinacol ester homodimers as bioactive agents.http://www.sciencedirect.com/science/article/pii/S2211715622002788Boronic acidHomodimerBioactivity |
| spellingShingle | Kaori Ota Jian-Rong Zhou Kazumi Yokomizo Tomohiro Kozako Shin-ichiro Honda Nobuhiro Kashige Makoto Furutachi Kunihiro Sumoto Bioactivity of boronic acid derivative homodimers Results in Chemistry Boronic acid Homodimer Bioactivity |
| title | Bioactivity of boronic acid derivative homodimers |
| title_full | Bioactivity of boronic acid derivative homodimers |
| title_fullStr | Bioactivity of boronic acid derivative homodimers |
| title_full_unstemmed | Bioactivity of boronic acid derivative homodimers |
| title_short | Bioactivity of boronic acid derivative homodimers |
| title_sort | bioactivity of boronic acid derivative homodimers |
| topic | Boronic acid Homodimer Bioactivity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715622002788 |
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