Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane Transplantation
Purpose: To report the management of a case of corneal melting two weeks after pterygium excision with intraoperative topical mitomycin C (MMC). Methods: Case report. Results: A 57-year-old male was referred to our Department for therapy of rapidly progressive corneal melting two weeks after primary...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2012-01-01
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| Series: | Case Reports in Ophthalmology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/336452 |
| _version_ | 1818344993109049344 |
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| author | Moreno Menghini Stephanie L. Watson Martina M. Bosch |
| author_facet | Moreno Menghini Stephanie L. Watson Martina M. Bosch |
| author_sort | Moreno Menghini |
| collection | DOAJ |
| description | Purpose: To report the management of a case of corneal melting two weeks after pterygium excision with intraoperative topical mitomycin C (MMC). Methods: Case report. Results: A 57-year-old male was referred to our Department for therapy of rapidly progressive corneal melting two weeks after primary pterygium surgery with MMC (0.2 mg/ml) in September 2009. Initial treatment consisted of topical and systemic immunosuppression along with topical antibiotics. Eight days after presentation, the patient underwent successful lamellar keratoplasty and amnion membrane transplantation. Subconjunctival injection of triamcinolone (40 mg/ml) and topical bevacizumab were used to manage the increased fibrovascular activity around the site of the former pterygium. Conclusion: Topical use of MMC during pterygium surgery may be related to serious postoperative complications such as progressive inflammatory corneal melting. The etiology may be multifactorial, which is related to MMC-induced inflammation and/or induced apoptosis. A therapeutic option is the described combination of systemic and local anti-inflammatory treatment along with lamellar keratoplasty and amniotic membrane transplantation. Adjunctive therapy may be needed if recurrence occurs. |
| first_indexed | 2024-12-13T16:55:18Z |
| format | Article |
| id | doaj.art-928ee2a20e224b33b483005bb5d47233 |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-12-13T16:55:18Z |
| publishDate | 2012-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-928ee2a20e224b33b483005bb5d472332022-12-21T23:37:56ZengKarger PublishersCase Reports in Ophthalmology1663-26992012-01-0131242910.1159/000336452336452Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane TransplantationMoreno MenghiniStephanie L. WatsonMartina M. BoschPurpose: To report the management of a case of corneal melting two weeks after pterygium excision with intraoperative topical mitomycin C (MMC). Methods: Case report. Results: A 57-year-old male was referred to our Department for therapy of rapidly progressive corneal melting two weeks after primary pterygium surgery with MMC (0.2 mg/ml) in September 2009. Initial treatment consisted of topical and systemic immunosuppression along with topical antibiotics. Eight days after presentation, the patient underwent successful lamellar keratoplasty and amnion membrane transplantation. Subconjunctival injection of triamcinolone (40 mg/ml) and topical bevacizumab were used to manage the increased fibrovascular activity around the site of the former pterygium. Conclusion: Topical use of MMC during pterygium surgery may be related to serious postoperative complications such as progressive inflammatory corneal melting. The etiology may be multifactorial, which is related to MMC-induced inflammation and/or induced apoptosis. A therapeutic option is the described combination of systemic and local anti-inflammatory treatment along with lamellar keratoplasty and amniotic membrane transplantation. Adjunctive therapy may be needed if recurrence occurs.http://www.karger.com/Article/FullText/336452Mitomycin CPterygiumCorneal meltingAmniotic membraneLamellar keratoplasty |
| spellingShingle | Moreno Menghini Stephanie L. Watson Martina M. Bosch Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane Transplantation Case Reports in Ophthalmology Mitomycin C Pterygium Corneal melting Amniotic membrane Lamellar keratoplasty |
| title | Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane Transplantation |
| title_full | Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane Transplantation |
| title_fullStr | Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane Transplantation |
| title_full_unstemmed | Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane Transplantation |
| title_short | Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane Transplantation |
| title_sort | corneal melting two weeks after pterygium excision with topical mitomycin c successfully treated with lamellar keratoplasty and amnion membrane transplantation |
| topic | Mitomycin C Pterygium Corneal melting Amniotic membrane Lamellar keratoplasty |
| url | http://www.karger.com/Article/FullText/336452 |
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