Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential
In this study, the nutraceutical potential of Capparis spinosa L. for the treatment of hyperglycemic states has been thoroughly investigated. A series of in vivo and in vitro tests have been conducted on fresh leaf, buds and salty buds (24 h desalted) processed to dry powder. 60% MeOH/H2O extracts w...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646461730244X |
| _version_ | 1818728382865604608 |
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| author | Adriano Mollica Gokhan Zengin Marcello Locatelli Azzurra Stefanucci Andrei Mocan Giorgia Macedonio Simone Carradori Olakunle Onaolapo Adejoke Onaolapo Juliet Adegoke Marufat Olaniyan Abdurrahman Aktumsek Ettore Novellino |
| author_facet | Adriano Mollica Gokhan Zengin Marcello Locatelli Azzurra Stefanucci Andrei Mocan Giorgia Macedonio Simone Carradori Olakunle Onaolapo Adejoke Onaolapo Juliet Adegoke Marufat Olaniyan Abdurrahman Aktumsek Ettore Novellino |
| author_sort | Adriano Mollica |
| collection | DOAJ |
| description | In this study, the nutraceutical potential of Capparis spinosa L. for the treatment of hyperglycemic states has been thoroughly investigated. A series of in vivo and in vitro tests have been conducted on fresh leaf, buds and salty buds (24 h desalted) processed to dry powder. 60% MeOH/H2O extracts were obtained for HPLC analysis and for α-amylase and α-glucosidase inhibition tests. To estimate the in vivo anti-diabetic effect, dry powders of C. spinosa leaf and buds were orally administered to streptozocin-induced diabetic rats over a period of 28 days. At the end of the experiment, animals were sacrificed, blood taken for assessment of lipid profile and liver/kidney biochemistry while section of the pancreas, liver and kidneys were processed for general histology. Results showed that the regular administration of C. spinosa leaf or buds normalized all the biochemical parameters and reversed the liver/kidney injury with variable degrees of organ protection. |
| first_indexed | 2024-12-17T22:29:07Z |
| format | Article |
| id | doaj.art-929004d5430c4207aa79d69dc0bdcac3 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T22:29:07Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-929004d5430c4207aa79d69dc0bdcac32022-12-21T21:30:15ZengElsevierJournal of Functional Foods1756-46462017-08-01353242Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potentialAdriano Mollica0Gokhan Zengin1Marcello Locatelli2Azzurra Stefanucci3Andrei Mocan4Giorgia Macedonio5Simone Carradori6Olakunle Onaolapo7Adejoke Onaolapo8Juliet Adegoke9Marufat Olaniyan10Abdurrahman Aktumsek11Ettore Novellino12Dipartimento di Farmacia, Università “G. d’Annunzio” di Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy; Corresponding author.Department of Biology, Science Faculty, Selcuk University Campus, 42250 Konya, TurkeyDipartimento di Farmacia, Università “G. d’Annunzio” di Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyDipartimento di Farmacia, Università “G. d’Annunzio” di Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyDepartment of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, 23 Gheorghe Marinescu Street, 400337 Cluj-Napoca, Romania; ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăştur 3-5, 400372 Cluj-Napoca, RomaniaDipartimento di Farmacia, Università “G. d’Annunzio” di Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyDipartimento di Farmacia, Università “G. d’Annunzio” di Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyDepartment of Pharmacology, Ladoke Akintola University of Technology, Osogbo, Osun State, NigeriaDepartment of Anatomy, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NigeriaDepartment of Pharmacology, Ladoke Akintola University of Technology, Osogbo, Osun State, NigeriaDepartment of Pharmacology, Ladoke Akintola University of Technology, Osogbo, Osun State, NigeriaDepartment of Biology, Science Faculty, Selcuk University Campus, 42250 Konya, TurkeyDipartimento di Farmacia, Università “Federico II” di Napoli, via D. Montesano, Napoli, ItalyIn this study, the nutraceutical potential of Capparis spinosa L. for the treatment of hyperglycemic states has been thoroughly investigated. A series of in vivo and in vitro tests have been conducted on fresh leaf, buds and salty buds (24 h desalted) processed to dry powder. 60% MeOH/H2O extracts were obtained for HPLC analysis and for α-amylase and α-glucosidase inhibition tests. To estimate the in vivo anti-diabetic effect, dry powders of C. spinosa leaf and buds were orally administered to streptozocin-induced diabetic rats over a period of 28 days. At the end of the experiment, animals were sacrificed, blood taken for assessment of lipid profile and liver/kidney biochemistry while section of the pancreas, liver and kidneys were processed for general histology. Results showed that the regular administration of C. spinosa leaf or buds normalized all the biochemical parameters and reversed the liver/kidney injury with variable degrees of organ protection.http://www.sciencedirect.com/science/article/pii/S175646461730244Xα-Amylaseα-GlucosidaseNutraceuticalsHPLCPolyphenolsFlavonoids |
| spellingShingle | Adriano Mollica Gokhan Zengin Marcello Locatelli Azzurra Stefanucci Andrei Mocan Giorgia Macedonio Simone Carradori Olakunle Onaolapo Adejoke Onaolapo Juliet Adegoke Marufat Olaniyan Abdurrahman Aktumsek Ettore Novellino Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential Journal of Functional Foods α-Amylase α-Glucosidase Nutraceuticals HPLC Polyphenols Flavonoids |
| title | Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential |
| title_full | Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential |
| title_fullStr | Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential |
| title_full_unstemmed | Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential |
| title_short | Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential |
| title_sort | anti diabetic and anti hyperlipidemic properties of capparis spinosa l in vivo and in vitro evaluation of its nutraceutical potential |
| topic | α-Amylase α-Glucosidase Nutraceuticals HPLC Polyphenols Flavonoids |
| url | http://www.sciencedirect.com/science/article/pii/S175646461730244X |
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