Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
Cell-to-cell transmission of TDP43 occurs in cell cultures and may contribute to pathological TDP43 propagation in FTLD-TDP. In this study, the authors demonstrate using mouse models that a single intracerebral injection of human brain-derived pathological TDP43 from FTLD-TDP cases initiates the pro...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06548-9 |
| _version_ | 1819126755400613888 |
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| author | Sílvia Porta Yan Xu Clark R. Restrepo Linda K. Kwong Bin Zhang Hannah J. Brown Edward B. Lee John Q. Trojanowski Virginia M.-Y. Lee |
| author_facet | Sílvia Porta Yan Xu Clark R. Restrepo Linda K. Kwong Bin Zhang Hannah J. Brown Edward B. Lee John Q. Trojanowski Virginia M.-Y. Lee |
| author_sort | Sílvia Porta |
| collection | DOAJ |
| description | Cell-to-cell transmission of TDP43 occurs in cell cultures and may contribute to pathological TDP43 propagation in FTLD-TDP. In this study, the authors demonstrate using mouse models that a single intracerebral injection of human brain-derived pathological TDP43 from FTLD-TDP cases initiates the process of seeding and spreading of TDP43 pathology in a spatio-temporal dependent manner in the brain. |
| first_indexed | 2024-12-22T08:01:04Z |
| format | Article |
| id | doaj.art-92900ea31995481996608cd988369b83 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:01:04Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-92900ea31995481996608cd988369b832022-12-21T18:33:15ZengNature PortfolioNature Communications2041-17232018-10-019111510.1038/s41467-018-06548-9Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivoSílvia Porta0Yan Xu1Clark R. Restrepo2Linda K. Kwong3Bin Zhang4Hannah J. Brown5Edward B. Lee6John Q. Trojanowski7Virginia M.-Y. Lee8Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaCenter for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaCenter for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaCenter for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaCenter for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaCenter for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaTranslational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaCenter for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaCenter for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaCell-to-cell transmission of TDP43 occurs in cell cultures and may contribute to pathological TDP43 propagation in FTLD-TDP. In this study, the authors demonstrate using mouse models that a single intracerebral injection of human brain-derived pathological TDP43 from FTLD-TDP cases initiates the process of seeding and spreading of TDP43 pathology in a spatio-temporal dependent manner in the brain.https://doi.org/10.1038/s41467-018-06548-9 |
| spellingShingle | Sílvia Porta Yan Xu Clark R. Restrepo Linda K. Kwong Bin Zhang Hannah J. Brown Edward B. Lee John Q. Trojanowski Virginia M.-Y. Lee Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo Nature Communications |
| title | Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo |
| title_full | Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo |
| title_fullStr | Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo |
| title_full_unstemmed | Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo |
| title_short | Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo |
| title_sort | patient derived frontotemporal lobar degeneration brain extracts induce formation and spreading of tdp 43 pathology in vivo |
| url | https://doi.org/10.1038/s41467-018-06548-9 |
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