Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer
Cell-free DNA (cf-DNA) has been reported to represent a suitable material for liquid biopsy in the diagnosis and prognosis of various cancers. We performed a meta-analysis of published data to investigate the diagnostic value of cf-DNA for renal cancer (RCa). Systematic searches were conducted using...
| Main Authors: | , , , , , , , , , , , , , |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.683844/full |
| _version_ | 1831773646140473344 |
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| author | Yipeng Xu Yingjun Jiang Mingke Yu Jianmin Lou Mei Song Han Xu Yingying Cui Xiaowei Zeng Xiaowei Zeng Qibo Wang Hanyun Ma Zongping Wang Shaoxing Zhu Guorong Li An Zhao |
| author_facet | Yipeng Xu Yingjun Jiang Mingke Yu Jianmin Lou Mei Song Han Xu Yingying Cui Xiaowei Zeng Xiaowei Zeng Qibo Wang Hanyun Ma Zongping Wang Shaoxing Zhu Guorong Li An Zhao |
| author_sort | Yipeng Xu |
| collection | DOAJ |
| description | Cell-free DNA (cf-DNA) has been reported to represent a suitable material for liquid biopsy in the diagnosis and prognosis of various cancers. We performed a meta-analysis of published data to investigate the diagnostic value of cf-DNA for renal cancer (RCa). Systematic searches were conducted using Pubmed, Embase databases, Web of Science, Medline and Cochrane Library to identify relevant publications until the 31st March 2021. For all patients, we evaluated the true diagnostic value of cf-DNA by calculating the number of true positive, false positive, true negative, and false negative, diagnoses by extracting specificity and sensitivity data from the selected literature. In total, 8 studies, featuring 754 RCa patients, and 355 healthy controls, met our inclusion criteria. The overall diagnostic sensitivity and specificity for cf-DNA was 0.71 (95% confidence interval (CI), 0.55–0.83) and 0.79 (95% CI, 0.66–0.88), respectively. The pooled positive likelihood ratio and pooled negative likelihood ratio were 3.42 (95% CI, 2.04–5.72) and 0.36 (95% CI, 0.23–0.58), respectively. The area under the summary receiver operating characteristic curve was 0.82 (95% CI, 0.79–0.85), and the diagnostic odds ratio was 7.80 (95% CI, 4.40–13.85). Collectively, our data demonstrate that cf-DNA has high specificity and sensitivity for diagnosing RCa. Therefore, cf-DNA is a useful biomarker for the diagnosis of RCa. |
| first_indexed | 2024-12-22T08:40:10Z |
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| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-22T08:40:10Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-92905470e12a4b6b836f2e70862b22622022-12-21T18:32:15ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-08-01810.3389/fmolb.2021.683844683844Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal CancerYipeng Xu0Yingjun Jiang1Mingke Yu2Jianmin Lou3Mei Song4Han Xu5Yingying Cui6Xiaowei Zeng7Xiaowei Zeng8Qibo Wang9Hanyun Ma10Zongping Wang11Shaoxing Zhu12Guorong Li13An Zhao14Department of Urology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzho, ChinaHangzhou Traditional Chinese Medicine Hospital, Zhejiang Chinese Medical University, Hangzhou, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Ultrasound, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, ChinaCentral Research Laboratory, Children’s Hospital of Nanchang University, Hangzhou, ChinaTranslational Radiation Oncology Research Laboratory, Department of Radiooncology and Radiotherapy, Charite University Hospital, Berlin, GermanyDepartment of Urology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzho, ChinaHangzhou Traditional Chinese Medicine Hospital, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Urology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzho, ChinaComprehensive Cancer Center, Charité Universitätsmedizin, Berlin, GermanyDepartment of Urology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzho, ChinaDepartment of Urology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzho, ChinaDepartment of Urology, North Hospital, University of Jean-Monnet, Saint-Etienne, FranceExperimental Research Center, Zhejiang Cancer Hospital, Institute of Cancer Research and Basic Medicine, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, ChinaCell-free DNA (cf-DNA) has been reported to represent a suitable material for liquid biopsy in the diagnosis and prognosis of various cancers. We performed a meta-analysis of published data to investigate the diagnostic value of cf-DNA for renal cancer (RCa). Systematic searches were conducted using Pubmed, Embase databases, Web of Science, Medline and Cochrane Library to identify relevant publications until the 31st March 2021. For all patients, we evaluated the true diagnostic value of cf-DNA by calculating the number of true positive, false positive, true negative, and false negative, diagnoses by extracting specificity and sensitivity data from the selected literature. In total, 8 studies, featuring 754 RCa patients, and 355 healthy controls, met our inclusion criteria. The overall diagnostic sensitivity and specificity for cf-DNA was 0.71 (95% confidence interval (CI), 0.55–0.83) and 0.79 (95% CI, 0.66–0.88), respectively. The pooled positive likelihood ratio and pooled negative likelihood ratio were 3.42 (95% CI, 2.04–5.72) and 0.36 (95% CI, 0.23–0.58), respectively. The area under the summary receiver operating characteristic curve was 0.82 (95% CI, 0.79–0.85), and the diagnostic odds ratio was 7.80 (95% CI, 4.40–13.85). Collectively, our data demonstrate that cf-DNA has high specificity and sensitivity for diagnosing RCa. Therefore, cf-DNA is a useful biomarker for the diagnosis of RCa.https://www.frontiersin.org/articles/10.3389/fmolb.2021.683844/fullcf-DNArenal cancerdiagnosisliquid biopsymeta-analysis |
| spellingShingle | Yipeng Xu Yingjun Jiang Mingke Yu Jianmin Lou Mei Song Han Xu Yingying Cui Xiaowei Zeng Xiaowei Zeng Qibo Wang Hanyun Ma Zongping Wang Shaoxing Zhu Guorong Li An Zhao Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer Frontiers in Molecular Biosciences cf-DNA renal cancer diagnosis liquid biopsy meta-analysis |
| title | Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer |
| title_full | Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer |
| title_fullStr | Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer |
| title_full_unstemmed | Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer |
| title_short | Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer |
| title_sort | meta analysis of the diagnostic value of cell free dna for renal cancer |
| topic | cf-DNA renal cancer diagnosis liquid biopsy meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.683844/full |
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