A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus
Abstract A 50‐year‐old female was admitted to our hospital because of mild throat discomfort. Esophagogastroduodenoscopy demonstrated multiple 2–3 mm diameter whitish granules in her hypopharynx and cervical esophagus. Based on biopsy specimens, we considered the lesions to represent normal tissue o...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | DEN Open |
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| Online Access: | https://doi.org/10.1002/deo2.160 |
| _version_ | 1797837242397360128 |
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| author | Hamada Kazu Shimode Yuzo Hata Yoshiyuki Kunou Hiroaki Kobayashi Rika Matsunaga Kazuhiro Kawaura Ken Mukai Tsuyoshi Kitakata Hidekazu Itoh Tohru Okuro Masashi Yamada Sohsuke |
| author_facet | Hamada Kazu Shimode Yuzo Hata Yoshiyuki Kunou Hiroaki Kobayashi Rika Matsunaga Kazuhiro Kawaura Ken Mukai Tsuyoshi Kitakata Hidekazu Itoh Tohru Okuro Masashi Yamada Sohsuke |
| author_sort | Hamada Kazu |
| collection | DOAJ |
| description | Abstract A 50‐year‐old female was admitted to our hospital because of mild throat discomfort. Esophagogastroduodenoscopy demonstrated multiple 2–3 mm diameter whitish granules in her hypopharynx and cervical esophagus. Based on biopsy specimens, we considered the lesions to represent normal tissue or very mild mucosal dysplasia. However, S‐100 immunohistochemical staining 3 years later led to a diagnosis of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus. Histological finding characteristics of neurofibroma were present in 72.7% of hypopharyngeal biopsy specimens and 33.3% of esophageal specimens. When diagnosing neurofibroma, it is important to perform biopsies at multiple locations and at different times and to enlist the cooperation of endoscopists and pathologists for immunohistochemical staining with S‐100. |
| first_indexed | 2024-04-09T15:22:43Z |
| format | Article |
| id | doaj.art-9292ab49d976433eb2835eba2b097c3d |
| institution | Directory Open Access Journal |
| issn | 2692-4609 |
| language | English |
| last_indexed | 2024-04-09T15:22:43Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj.art-9292ab49d976433eb2835eba2b097c3d2023-04-29T05:12:58ZengWileyDEN Open2692-46092023-04-0131n/an/a10.1002/deo2.160A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagusHamada Kazu0Shimode Yuzo1Hata Yoshiyuki2Kunou Hiroaki3Kobayashi Rika4Matsunaga Kazuhiro5Kawaura Ken6Mukai Tsuyoshi7Kitakata Hidekazu8Itoh Tohru9Okuro Masashi10Yamada Sohsuke11Department of Gastroenterological Endoscopy Kanazawa Medical University Ishikawa JapanDepartment of Head and Neck Surgery Kanazawa Medical University Ishikawa JapanDepartment of Gastroenterological Endoscopy Kanazawa Medical University Ishikawa JapanDepartment of Gastroenterological Endoscopy Kanazawa Medical University Ishikawa JapanDepartment of Gastroenterological Endoscopy Kanazawa Medical University Ishikawa JapanDepartment of Gastroenterological Endoscopy Kanazawa Medical University Ishikawa JapanDepartment of Gastroenterological Endoscopy Kanazawa Medical University Ishikawa JapanDepartment of Gastroenterological Endoscopy Kanazawa Medical University Ishikawa JapanDepartment of Gastroenterological Endoscopy Kanazawa Medical University Ishikawa JapanDepartment of Gastroenterological Endoscopy Kanazawa Medical University Ishikawa JapanDepartment of Geriatric Medicine Kanazawa Medical University Ishikawa JapanDepartment of Pathology and Laboratory Medicine Kanazawa Medical University Ishikawa JapanAbstract A 50‐year‐old female was admitted to our hospital because of mild throat discomfort. Esophagogastroduodenoscopy demonstrated multiple 2–3 mm diameter whitish granules in her hypopharynx and cervical esophagus. Based on biopsy specimens, we considered the lesions to represent normal tissue or very mild mucosal dysplasia. However, S‐100 immunohistochemical staining 3 years later led to a diagnosis of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus. Histological finding characteristics of neurofibroma were present in 72.7% of hypopharyngeal biopsy specimens and 33.3% of esophageal specimens. When diagnosing neurofibroma, it is important to perform biopsies at multiple locations and at different times and to enlist the cooperation of endoscopists and pathologists for immunohistochemical staining with S‐100.https://doi.org/10.1002/deo2.160biopsyendoscopyesophagushypopharynxneurofibroma |
| spellingShingle | Hamada Kazu Shimode Yuzo Hata Yoshiyuki Kunou Hiroaki Kobayashi Rika Matsunaga Kazuhiro Kawaura Ken Mukai Tsuyoshi Kitakata Hidekazu Itoh Tohru Okuro Masashi Yamada Sohsuke A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus DEN Open biopsy endoscopy esophagus hypopharynx neurofibroma |
| title | A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus |
| title_full | A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus |
| title_fullStr | A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus |
| title_full_unstemmed | A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus |
| title_short | A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus |
| title_sort | case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus |
| topic | biopsy endoscopy esophagus hypopharynx neurofibroma |
| url | https://doi.org/10.1002/deo2.160 |
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