Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach
Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments (NF). This study performs molecular dynamics (M...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/4/540 |
| _version_ | 1797538547690897408 |
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| author | Md Ishak Khan Fuad Hasan Khandakar Abu Hasan Al Mahmud Ashfaq Adnan |
| author_facet | Md Ishak Khan Fuad Hasan Khandakar Abu Hasan Al Mahmud Ashfaq Adnan |
| author_sort | Md Ishak Khan |
| collection | DOAJ |
| description | Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments (NF). This study performs molecular dynamics (MD) simulations on NFs to extract their strain rate-dependent behavior. It is found that they are highly stretchable and show multiple stages of unfolding. Furthermore, NFs show high tensile stiffness. Also, viscoelastic modeling shows that they correspond to simplified viscoelastic models. This study effectively enhances the existent axonal models focusing on axonal injury. |
| first_indexed | 2024-03-10T12:32:59Z |
| format | Article |
| id | doaj.art-9294829af8044119b6893c3fef4dcd66 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T12:32:59Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-9294829af8044119b6893c3fef4dcd662023-11-21T14:31:31ZengMDPI AGBiomolecules2218-273X2021-04-0111454010.3390/biom11040540Viscoelastic Response of Neurofilaments: An Atomistic Simulation ApproachMd Ishak Khan0Fuad Hasan1Khandakar Abu Hasan Al Mahmud2Ashfaq Adnan3Department of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019, USADepartment of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019, USADepartment of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019, USADepartment of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019, USAExistent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments (NF). This study performs molecular dynamics (MD) simulations on NFs to extract their strain rate-dependent behavior. It is found that they are highly stretchable and show multiple stages of unfolding. Furthermore, NFs show high tensile stiffness. Also, viscoelastic modeling shows that they correspond to simplified viscoelastic models. This study effectively enhances the existent axonal models focusing on axonal injury.https://www.mdpi.com/2218-273X/11/4/540neurofilamentsaxonal cytoskeletonaxonal injurymechanical behaviorviscoelastic modeling |
| spellingShingle | Md Ishak Khan Fuad Hasan Khandakar Abu Hasan Al Mahmud Ashfaq Adnan Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach Biomolecules neurofilaments axonal cytoskeleton axonal injury mechanical behavior viscoelastic modeling |
| title | Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach |
| title_full | Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach |
| title_fullStr | Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach |
| title_full_unstemmed | Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach |
| title_short | Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach |
| title_sort | viscoelastic response of neurofilaments an atomistic simulation approach |
| topic | neurofilaments axonal cytoskeleton axonal injury mechanical behavior viscoelastic modeling |
| url | https://www.mdpi.com/2218-273X/11/4/540 |
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