The Genetic Causal Association between Educational Attainment and Risk of 12 Common Musculoskeletal Disorders: A Two‐Sample Mendelian Randomization
Objective In numerous observational studies, there has been an indication that educational attainment (EA) can impact the intensity of pain and disability resulting from chronic musculoskeletal disorders. Nonetheless, the association observed in these studies is not entirely conclusive. The aim of t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Orthopaedic Surgery |
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| Online Access: | https://doi.org/10.1111/os.13821 |
| _version_ | 1797640281001033728 |
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| author | Kaibo Sun Yue Ming Yuangang Wu Yi Zeng Jiawen Xu Limin Wu Mingyang Li Bin Shen |
| author_facet | Kaibo Sun Yue Ming Yuangang Wu Yi Zeng Jiawen Xu Limin Wu Mingyang Li Bin Shen |
| author_sort | Kaibo Sun |
| collection | DOAJ |
| description | Objective In numerous observational studies, there has been an indication that educational attainment (EA) can impact the intensity of pain and disability resulting from chronic musculoskeletal disorders. Nonetheless, the association observed in these studies is not entirely conclusive. The aim of this study was to investigate the genetic causal relationship between educational attainment and 12 musculoskeletal disorders using Mendelian randomization (MR). Methods The meta‐analysis of genome‐wide association studies (GWAS) identified 3952 single‐nucleotide polymorphisms (SNPs) associated with educational attainment (EA) from the Social Science Genetic Association Consortium (SSGAC). Genetic data for 12 musculoskeletal disorders, including osteonecrosis, osteoporosis, osteomyelitis, low back pain, gout, spinal stenosis, rheumatoid arthritis, meniscus derangement, rotator cuff syndrome, ankylosing spondylitis, cervicobrachial syndrome, and lateral epicondylitis, were obtained from the FinnGen consortium. We conducted a two‐sample Mendelian randomization analysis to examine the causal effect of EA on the risk of these musculoskeletal disorders using the TwoSampleMR package in R. Results Based on the inverse‐variance weighted (IVW) method, we found that a genetically predicted per standard deviation (SD) increase in EA was inversely associated with low back pain [odds ratio (OR) 0.46, 95% confidence interval (Cl) 0.51–0.61, p < 0.001], spinal stenosis (OR 0.62, 95% Cl 0.54–0.71, p < 0.001), rheumatoid arthritis (OR 0.65, 95% Cl 0.55–0.76, p < 0.001), meniscus derangement (OR 0.73, 95% Cl 0.65–0.82, p < 0.001), rotator cuff syndrome (OR 0.55, 95% Cl 0.49–0.61, p < 0.001), cervicobrachial syndrome (OR 0.50, 95% Cl 0.42–0.60, p < 0.001), and lateral epicondylitis (OR 0.30, 95% Cl 0.24–0.37, p < 0.001). There was no causal association between EA and osteonecrosis (OR 1.11, 95% CI 0.76–1.72, p = 0.60), osteoporosis (OR 0.91, 95% CI 0.65–1.27, p = 0.59), or osteomyelitis (OR 0.90, 95% CI 0.75–1.01, p = 0.22). Genetic predisposition to EA had a suggestive causal association with gout (OR 0.80, 95% CI 0.68–0.95, p = 0.01) and ankylosing spondylitis (OR 0.64, 95% CI 0.45–0.91, p = 0.01) after Bonferroni correction. None of the analyses revealed any horizontal pleiotropy or heterogeneity. Conclusion In our investigation, we have uncovered evidence supporting a causal relationship between low level of EA and the incidence of certain musculoskeletal disorders. In the future, it is imperative to ascertain risk factors such as lifestyle patterns linked with EA to uncover the underlying causal relationship and offer informed interventions for individuals. |
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| language | English |
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| series | Orthopaedic Surgery |
| spelling | doaj.art-92955947ca864b9aaa377a4734b0c9162023-11-03T02:57:47ZengWileyOrthopaedic Surgery1757-78531757-78612023-11-0115112814282110.1111/os.13821The Genetic Causal Association between Educational Attainment and Risk of 12 Common Musculoskeletal Disorders: A Two‐Sample Mendelian RandomizationKaibo Sun0Yue Ming1Yuangang Wu2Yi Zeng3Jiawen Xu4Limin Wu5Mingyang Li6Bin Shen7Department of Orthopaedics Surgery, Orthopaedic Research Institute West China Hospital, Sichuan University Chengdu ChinaLaboratory of Molecular Oncology, Frontiers Science Center for Disease‐related Molecular Networks West China Hospital, Sichuan University Chengdu ChinaDepartment of Orthopaedics Surgery, Orthopaedic Research Institute West China Hospital, Sichuan University Chengdu ChinaDepartment of Orthopaedics Surgery, Orthopaedic Research Institute West China Hospital, Sichuan University Chengdu ChinaDepartment of Orthopaedics Surgery, Orthopaedic Research Institute West China Hospital, Sichuan University Chengdu ChinaDepartment of Orthopaedics Surgery, Orthopaedic Research Institute West China Hospital, Sichuan University Chengdu ChinaDepartment of Orthopaedics Surgery, Orthopaedic Research Institute West China Hospital, Sichuan University Chengdu ChinaDepartment of Orthopaedics Surgery, Orthopaedic Research Institute West China Hospital, Sichuan University Chengdu ChinaObjective In numerous observational studies, there has been an indication that educational attainment (EA) can impact the intensity of pain and disability resulting from chronic musculoskeletal disorders. Nonetheless, the association observed in these studies is not entirely conclusive. The aim of this study was to investigate the genetic causal relationship between educational attainment and 12 musculoskeletal disorders using Mendelian randomization (MR). Methods The meta‐analysis of genome‐wide association studies (GWAS) identified 3952 single‐nucleotide polymorphisms (SNPs) associated with educational attainment (EA) from the Social Science Genetic Association Consortium (SSGAC). Genetic data for 12 musculoskeletal disorders, including osteonecrosis, osteoporosis, osteomyelitis, low back pain, gout, spinal stenosis, rheumatoid arthritis, meniscus derangement, rotator cuff syndrome, ankylosing spondylitis, cervicobrachial syndrome, and lateral epicondylitis, were obtained from the FinnGen consortium. We conducted a two‐sample Mendelian randomization analysis to examine the causal effect of EA on the risk of these musculoskeletal disorders using the TwoSampleMR package in R. Results Based on the inverse‐variance weighted (IVW) method, we found that a genetically predicted per standard deviation (SD) increase in EA was inversely associated with low back pain [odds ratio (OR) 0.46, 95% confidence interval (Cl) 0.51–0.61, p < 0.001], spinal stenosis (OR 0.62, 95% Cl 0.54–0.71, p < 0.001), rheumatoid arthritis (OR 0.65, 95% Cl 0.55–0.76, p < 0.001), meniscus derangement (OR 0.73, 95% Cl 0.65–0.82, p < 0.001), rotator cuff syndrome (OR 0.55, 95% Cl 0.49–0.61, p < 0.001), cervicobrachial syndrome (OR 0.50, 95% Cl 0.42–0.60, p < 0.001), and lateral epicondylitis (OR 0.30, 95% Cl 0.24–0.37, p < 0.001). There was no causal association between EA and osteonecrosis (OR 1.11, 95% CI 0.76–1.72, p = 0.60), osteoporosis (OR 0.91, 95% CI 0.65–1.27, p = 0.59), or osteomyelitis (OR 0.90, 95% CI 0.75–1.01, p = 0.22). Genetic predisposition to EA had a suggestive causal association with gout (OR 0.80, 95% CI 0.68–0.95, p = 0.01) and ankylosing spondylitis (OR 0.64, 95% CI 0.45–0.91, p = 0.01) after Bonferroni correction. None of the analyses revealed any horizontal pleiotropy or heterogeneity. Conclusion In our investigation, we have uncovered evidence supporting a causal relationship between low level of EA and the incidence of certain musculoskeletal disorders. In the future, it is imperative to ascertain risk factors such as lifestyle patterns linked with EA to uncover the underlying causal relationship and offer informed interventions for individuals.https://doi.org/10.1111/os.13821Causal AssociationEducation AttainmentMendelian RandomizationMusculoskeletal Disorders |
| spellingShingle | Kaibo Sun Yue Ming Yuangang Wu Yi Zeng Jiawen Xu Limin Wu Mingyang Li Bin Shen The Genetic Causal Association between Educational Attainment and Risk of 12 Common Musculoskeletal Disorders: A Two‐Sample Mendelian Randomization Orthopaedic Surgery Causal Association Education Attainment Mendelian Randomization Musculoskeletal Disorders |
| title | The Genetic Causal Association between Educational Attainment and Risk of 12 Common Musculoskeletal Disorders: A Two‐Sample Mendelian Randomization |
| title_full | The Genetic Causal Association between Educational Attainment and Risk of 12 Common Musculoskeletal Disorders: A Two‐Sample Mendelian Randomization |
| title_fullStr | The Genetic Causal Association between Educational Attainment and Risk of 12 Common Musculoskeletal Disorders: A Two‐Sample Mendelian Randomization |
| title_full_unstemmed | The Genetic Causal Association between Educational Attainment and Risk of 12 Common Musculoskeletal Disorders: A Two‐Sample Mendelian Randomization |
| title_short | The Genetic Causal Association between Educational Attainment and Risk of 12 Common Musculoskeletal Disorders: A Two‐Sample Mendelian Randomization |
| title_sort | genetic causal association between educational attainment and risk of 12 common musculoskeletal disorders a two sample mendelian randomization |
| topic | Causal Association Education Attainment Mendelian Randomization Musculoskeletal Disorders |
| url | https://doi.org/10.1111/os.13821 |
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