Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia
Short interval intracortical inhibition (SICI) is a biomarker for altered motor inhibition in schizophrenia, but the manner in which distant sites influence the inhibitory cortical-effector response remains elusive. Our study investigated local and long-distance resting state functional connectivity...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221001327 |
| _version_ | 1818681920238649344 |
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| author | Stephanie M. Hare Xiaoming Du Bhim M. Adhikari Shuo Chen Chen Mo Ann Summerfelt Mark D. Kvarta Laura Garcia Peter Kochunov L. Elliot Hong |
| author_facet | Stephanie M. Hare Xiaoming Du Bhim M. Adhikari Shuo Chen Chen Mo Ann Summerfelt Mark D. Kvarta Laura Garcia Peter Kochunov L. Elliot Hong |
| author_sort | Stephanie M. Hare |
| collection | DOAJ |
| description | Short interval intracortical inhibition (SICI) is a biomarker for altered motor inhibition in schizophrenia, but the manner in which distant sites influence the inhibitory cortical-effector response remains elusive. Our study investigated local and long-distance resting state functional connectivity (rsFC) markers of SICI in a sample of N = 23 patients with schizophrenia and N = 29 controls. Local functional connectivity was quantified using regional homogeneity (ReHo) analysis and long-range connectivity was estimated using seed-based rsFC analysis. Direct and indirect effects of connectivity measures on SICI were modeled using mediation analysis. Higher SICI ratios (indicating reduced inhibition) in patients were associated with lower ReHo in the right insula. Follow-up rsFC analyses showed that higher SICI scores (indicating reduced inhibition) were associated with reduced connectivity between right insula and hubs of the corticospinal pathway: sensorimotor cortex and basal ganglia. Mediation analysis supported a model in which the direct effect of local insular connectivity strength on SICI is mediated by the interhemispheric connectivity between insula and left sensorimotor cortex. The broader clinical implications of these findings are discussed with emphasis on how these preliminary findings might inform novel interventions designed to restore or improve SICI in schizophrenia and deepen our understanding of motor inhibitory control and impact of abnormal signaling in motor-inhibitory pathways in schizophrenia. |
| first_indexed | 2024-12-17T10:10:37Z |
| format | Article |
| id | doaj.art-929620bcbfe74c7698b1b741419d6d62 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-17T10:10:37Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-929620bcbfe74c7698b1b741419d6d622022-12-21T21:53:03ZengElsevierNeuroImage: Clinical2213-15822021-01-0131102688Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophreniaStephanie M. Hare0Xiaoming Du1Bhim M. Adhikari2Shuo Chen3Chen Mo4Ann Summerfelt5Mark D. Kvarta6Laura Garcia7Peter Kochunov8L. Elliot Hong9Corresponding author at: Maryland Psychiatric Research Center, P.O. Box 21247, Baltimore, MD 21228, United States.; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesShort interval intracortical inhibition (SICI) is a biomarker for altered motor inhibition in schizophrenia, but the manner in which distant sites influence the inhibitory cortical-effector response remains elusive. Our study investigated local and long-distance resting state functional connectivity (rsFC) markers of SICI in a sample of N = 23 patients with schizophrenia and N = 29 controls. Local functional connectivity was quantified using regional homogeneity (ReHo) analysis and long-range connectivity was estimated using seed-based rsFC analysis. Direct and indirect effects of connectivity measures on SICI were modeled using mediation analysis. Higher SICI ratios (indicating reduced inhibition) in patients were associated with lower ReHo in the right insula. Follow-up rsFC analyses showed that higher SICI scores (indicating reduced inhibition) were associated with reduced connectivity between right insula and hubs of the corticospinal pathway: sensorimotor cortex and basal ganglia. Mediation analysis supported a model in which the direct effect of local insular connectivity strength on SICI is mediated by the interhemispheric connectivity between insula and left sensorimotor cortex. The broader clinical implications of these findings are discussed with emphasis on how these preliminary findings might inform novel interventions designed to restore or improve SICI in schizophrenia and deepen our understanding of motor inhibitory control and impact of abnormal signaling in motor-inhibitory pathways in schizophrenia.http://www.sciencedirect.com/science/article/pii/S2213158221001327SchizophreniaTranscranial magnetic stimulation (TMS)Short-interval intracortical inhibition (SICI)Resting fMRIRegional homogeneity (ReHo) |
| spellingShingle | Stephanie M. Hare Xiaoming Du Bhim M. Adhikari Shuo Chen Chen Mo Ann Summerfelt Mark D. Kvarta Laura Garcia Peter Kochunov L. Elliot Hong Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia NeuroImage: Clinical Schizophrenia Transcranial magnetic stimulation (TMS) Short-interval intracortical inhibition (SICI) Resting fMRI Regional homogeneity (ReHo) |
| title | Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia |
| title_full | Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia |
| title_fullStr | Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia |
| title_full_unstemmed | Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia |
| title_short | Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia |
| title_sort | mapping local and long distance resting connectivity markers of tms related inhibition reduction in schizophrenia |
| topic | Schizophrenia Transcranial magnetic stimulation (TMS) Short-interval intracortical inhibition (SICI) Resting fMRI Regional homogeneity (ReHo) |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221001327 |
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