Cannabinoids modulate food preference and consumption in Drosophila melanogaster
Abstract Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids aff...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-84180-2 |
| _version_ | 1818858172322938880 |
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| author | Jianzheng He Alice Mei Xien Tan Si Yun Ng Menglong Rui Fengwei Yu |
| author_facet | Jianzheng He Alice Mei Xien Tan Si Yun Ng Menglong Rui Fengwei Yu |
| author_sort | Jianzheng He |
| collection | DOAJ |
| description | Abstract Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of two important sensory regulators Poxn and Orco. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model. |
| first_indexed | 2024-12-19T08:52:04Z |
| format | Article |
| id | doaj.art-9297ef9db7e54869acbd7fa6a6e5f29e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T08:52:04Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9297ef9db7e54869acbd7fa6a6e5f29e2022-12-21T20:28:42ZengNature PortfolioScientific Reports2045-23222021-02-0111111310.1038/s41598-021-84180-2Cannabinoids modulate food preference and consumption in Drosophila melanogasterJianzheng He0Alice Mei Xien Tan1Si Yun Ng2Menglong Rui3Fengwei Yu4Temasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeAbstract Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of two important sensory regulators Poxn and Orco. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model.https://doi.org/10.1038/s41598-021-84180-2 |
| spellingShingle | Jianzheng He Alice Mei Xien Tan Si Yun Ng Menglong Rui Fengwei Yu Cannabinoids modulate food preference and consumption in Drosophila melanogaster Scientific Reports |
| title | Cannabinoids modulate food preference and consumption in Drosophila melanogaster |
| title_full | Cannabinoids modulate food preference and consumption in Drosophila melanogaster |
| title_fullStr | Cannabinoids modulate food preference and consumption in Drosophila melanogaster |
| title_full_unstemmed | Cannabinoids modulate food preference and consumption in Drosophila melanogaster |
| title_short | Cannabinoids modulate food preference and consumption in Drosophila melanogaster |
| title_sort | cannabinoids modulate food preference and consumption in drosophila melanogaster |
| url | https://doi.org/10.1038/s41598-021-84180-2 |
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