18F-FET and 18F-FCH uptake in human glioblastoma T98G cell lines
Despite complex treatment of surgery, radiotherapy and chemotherapy, high grade gliomas often recur. Differentiation between post-treatment changes and recurrence is difficult. 18F-methyl-choline (18F-FCH) is frequently used in staging and detection of recurrent prostate cancer disease as well as so...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-06-01
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| Series: | Radiology and Oncology |
| Online Access: | https://doi.org/10.1515/raon-2016-0022 |
| _version_ | 1818581501062676480 |
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| author | Persico Marco Giovanni Buroni Federica Eleonora Pasi Francesca Lodola Lorenzo Aprile Carlo Nano Rosanna Hodolic Marina |
| author_facet | Persico Marco Giovanni Buroni Federica Eleonora Pasi Francesca Lodola Lorenzo Aprile Carlo Nano Rosanna Hodolic Marina |
| author_sort | Persico Marco Giovanni |
| collection | DOAJ |
| description | Despite complex treatment of surgery, radiotherapy and chemotherapy, high grade gliomas often recur. Differentiation between post-treatment changes and recurrence is difficult. 18F-methyl-choline (18F-FCH) is frequently used in staging and detection of recurrent prostate cancer disease as well as some brain tumours; however accumulation in inflammatory tissue limits its specificity. The 18F-ethyl-tyrosine (18F-FET) shows a specific uptake in malignant cells, resulting from increased expression of amino acid transporters or diffusing through the disrupted blood-brain barrier. 18F-FET exhibits lower uptake in machrophages and other inflammatory cells. Aim of this study was to evaluate 18F-FCH and 18F-FET uptake by human glioblastoma T98G cells. |
| first_indexed | 2024-12-16T07:34:29Z |
| format | Article |
| id | doaj.art-929bd10db806485c95db36fd51f6ecff |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-12-16T07:34:29Z |
| publishDate | 2016-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-929bd10db806485c95db36fd51f6ecff2022-12-21T22:39:16ZengSciendoRadiology and Oncology1581-32072016-06-0150215315810.1515/raon-2016-0022raon-2016-002218F-FET and 18F-FCH uptake in human glioblastoma T98G cell linesPersico Marco Giovanni0Buroni Federica Eleonora1Pasi Francesca2Lodola Lorenzo3Aprile Carlo4Nano Rosanna5Hodolic Marina6Department of Oncohaematology, Nuclear Medicine Unit, IRCCS San Matteo Hospital Foundation, Pavia, ItalyDepartment of Oncohaematology, Nuclear Medicine Unit, IRCCS San Matteo Hospital Foundation, Pavia, ItalyDepartment of Oncohaematology, Radiotherapy Unit, IRCCS San Matteo Hospital Foundation, Pavia, ItalyDepartment of Oncohaematology, Nuclear Medicine Unit, IRCCS San Matteo Hospital Foundation, Pavia, ItalyDepartment of Oncohaematology, Nuclear Medicine Unit, IRCCS San Matteo Hospital Foundation, Pavia, ItalyDepartment of Biology and Biotecnology “Lazzaro Spallanzani”, University of Pavia, Pavia, ItalyNuclear medicine research department, Iason, Graz, AustriaDespite complex treatment of surgery, radiotherapy and chemotherapy, high grade gliomas often recur. Differentiation between post-treatment changes and recurrence is difficult. 18F-methyl-choline (18F-FCH) is frequently used in staging and detection of recurrent prostate cancer disease as well as some brain tumours; however accumulation in inflammatory tissue limits its specificity. The 18F-ethyl-tyrosine (18F-FET) shows a specific uptake in malignant cells, resulting from increased expression of amino acid transporters or diffusing through the disrupted blood-brain barrier. 18F-FET exhibits lower uptake in machrophages and other inflammatory cells. Aim of this study was to evaluate 18F-FCH and 18F-FET uptake by human glioblastoma T98G cells.https://doi.org/10.1515/raon-2016-0022 |
| spellingShingle | Persico Marco Giovanni Buroni Federica Eleonora Pasi Francesca Lodola Lorenzo Aprile Carlo Nano Rosanna Hodolic Marina 18F-FET and 18F-FCH uptake in human glioblastoma T98G cell lines Radiology and Oncology |
| title | 18F-FET and 18F-FCH uptake in human glioblastoma T98G cell lines |
| title_full | 18F-FET and 18F-FCH uptake in human glioblastoma T98G cell lines |
| title_fullStr | 18F-FET and 18F-FCH uptake in human glioblastoma T98G cell lines |
| title_full_unstemmed | 18F-FET and 18F-FCH uptake in human glioblastoma T98G cell lines |
| title_short | 18F-FET and 18F-FCH uptake in human glioblastoma T98G cell lines |
| title_sort | 18f fet and 18f fch uptake in human glioblastoma t98g cell lines |
| url | https://doi.org/10.1515/raon-2016-0022 |
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