Altered Immunomodulatory Responses in the CX3CL1/CX3CR1 Axis Mediated by hMSCs in an Early In Vitro SOD1<sup>G93A</sup> Model of ALS

Altered Immunomodulatory Responses in the CX3CL1/CX3CR1 Axis Mediated by hMSCs in an Early In Vitro SOD1<sup>G93A</sup> Model of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron (MN) disease characterized by progressive MN loss and muscular atrophy resulting in rapidly progressive paralysis and respiratory failure. Human mesenchymal stem/stromal cell (hMSC)-based therapy has been suggested to prolong MN survival vi...

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Bibliographic Details
Main Authors: Anastasia Sarikidi, Ekaterini Kefalakes, Christine S. Falk, Ruth Esser, Arnold Ganser, Nadine Thau-Habermann, Susanne Petri
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
amyotrophic lateral sclerosis
SOD1<sup>G93A</sup>
motor neurons
human mesenchymal stem/stromal cells
fractalkine
Online Access:https://www.mdpi.com/2227-9059/10/11/2916

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