Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping
AbstractBackground It is unknown which features of unipolar atrial electrogram (U-AEGM) morphology are affected by ageing and whether age-related changes in U-AEGM morphology are equally distributed throughout the right and left atria.Patients and methods Epicardial high-resolution mapping was perfo...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2193426 |
| _version_ | 1797353749006516224 |
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| author | Ziliang Ye Mathijs S. van Schie Annejet Heida Lianne N. van Staveren Frank R. N. van Schaagen Yannick J. H. J. Taverne Natasja M. S. de Groot |
| author_facet | Ziliang Ye Mathijs S. van Schie Annejet Heida Lianne N. van Staveren Frank R. N. van Schaagen Yannick J. H. J. Taverne Natasja M. S. de Groot |
| author_sort | Ziliang Ye |
| collection | DOAJ |
| description | AbstractBackground It is unknown which features of unipolar atrial electrogram (U-AEGM) morphology are affected by ageing and whether age-related changes in U-AEGM morphology are equally distributed throughout the right and left atria.Patients and methods Epicardial high-resolution mapping was performed in patients undergoing coronary artery bypass grafting surgery during sinus rhythm (SR). Mapping areas include the right atrium (RA), left atrium (LA), pulmonary vein area (PVA) and Bachmann’s bundle (BB). Patients were categorized into a young (age < 60) and aged (age ≥ 60) group. U-AEGM were classified as single potentials (SPs, one deflection), short double potentials (SDPs, deflection interval ≤ 15ms), long double potentials (LDPs, deflection interval > 15ms) and fractionated potentials (FPs, ≥3 deflections).Results A total of 213 patients (age: 67 (59–73) years; young group N = 58, aged group N = 155) were included. Only at BB, the proportion of SPs (p = 0.007) was significantly higher in the young group, while the proportion of SDPs (p = 0.051), LDPs (p = 0.004) and FPs (p = 0.006) was higher in the aged group. After adjusting for potential confounders, older age was associated with a reduction in SPs [regression coefficient (β): −6.33, 95% confident interval (CI): −10.37 to −2.30] at the expense of an increased proportion of SDPs (β: 2.49, 95% CI: 0.09 to 4.89), LDPs (β: 1.94, 95% CI: 0.21 to 3.68) and FPs (β: 1.90, 95% CI: 0.62 to 3.18).Conclusions Age-related remodeling particularly affects BB as indicated by the decreased amount of non-SP at this location in the elderly.Key MessagesAgeing preferentially affects the morphology of unipolar atrial electrograms recorded at Bachmann’s bundle.At Bachmann’s bundle, the proportion of short double-, long double- and fractionated potentials increase during ageing at the expense of a decrease in the proportion of single potentials, reflecting aggravation of abnormalities in conduction.The increase in abnormal unipolar atrial electrograms at Bachmann’s bundle during ageing supports the concept that Bachmann’s bundle may play an important role in development of age-related arrhythmias such as atrial fibrillation. |
| first_indexed | 2024-03-08T13:35:32Z |
| format | Article |
| id | doaj.art-929fa903eb0344279103a95f0bcd3eea |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:35:32Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Medicine |
| spelling | doaj.art-929fa903eb0344279103a95f0bcd3eea2024-01-16T19:13:21ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-015511431144110.1080/07853890.2023.2193426Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mappingZiliang Ye0Mathijs S. van Schie1Annejet Heida2Lianne N. van Staveren3Frank R. N. van Schaagen4Yannick J. H. J. Taverne5Natasja M. S. de Groot6Department of Cardiology, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, The NetherlandsTranslational Cardiothoracic Surgery Research Lab, Department of Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, The NetherlandsTranslational Cardiothoracic Surgery Research Lab, Department of Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, The NetherlandsAbstractBackground It is unknown which features of unipolar atrial electrogram (U-AEGM) morphology are affected by ageing and whether age-related changes in U-AEGM morphology are equally distributed throughout the right and left atria.Patients and methods Epicardial high-resolution mapping was performed in patients undergoing coronary artery bypass grafting surgery during sinus rhythm (SR). Mapping areas include the right atrium (RA), left atrium (LA), pulmonary vein area (PVA) and Bachmann’s bundle (BB). Patients were categorized into a young (age < 60) and aged (age ≥ 60) group. U-AEGM were classified as single potentials (SPs, one deflection), short double potentials (SDPs, deflection interval ≤ 15ms), long double potentials (LDPs, deflection interval > 15ms) and fractionated potentials (FPs, ≥3 deflections).Results A total of 213 patients (age: 67 (59–73) years; young group N = 58, aged group N = 155) were included. Only at BB, the proportion of SPs (p = 0.007) was significantly higher in the young group, while the proportion of SDPs (p = 0.051), LDPs (p = 0.004) and FPs (p = 0.006) was higher in the aged group. After adjusting for potential confounders, older age was associated with a reduction in SPs [regression coefficient (β): −6.33, 95% confident interval (CI): −10.37 to −2.30] at the expense of an increased proportion of SDPs (β: 2.49, 95% CI: 0.09 to 4.89), LDPs (β: 1.94, 95% CI: 0.21 to 3.68) and FPs (β: 1.90, 95% CI: 0.62 to 3.18).Conclusions Age-related remodeling particularly affects BB as indicated by the decreased amount of non-SP at this location in the elderly.Key MessagesAgeing preferentially affects the morphology of unipolar atrial electrograms recorded at Bachmann’s bundle.At Bachmann’s bundle, the proportion of short double-, long double- and fractionated potentials increase during ageing at the expense of a decrease in the proportion of single potentials, reflecting aggravation of abnormalities in conduction.The increase in abnormal unipolar atrial electrograms at Bachmann’s bundle during ageing supports the concept that Bachmann’s bundle may play an important role in development of age-related arrhythmias such as atrial fibrillation.https://www.tandfonline.com/doi/10.1080/07853890.2023.2193426Unipolar atrial electrogramageingcoronary artery bypass graftingsinus rhythmepicardial mapping |
| spellingShingle | Ziliang Ye Mathijs S. van Schie Annejet Heida Lianne N. van Staveren Frank R. N. van Schaagen Yannick J. H. J. Taverne Natasja M. S. de Groot Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping Annals of Medicine Unipolar atrial electrogram ageing coronary artery bypass grafting sinus rhythm epicardial mapping |
| title | Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping |
| title_full | Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping |
| title_fullStr | Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping |
| title_full_unstemmed | Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping |
| title_short | Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping |
| title_sort | unipolar atrial electrogram morphology is affected by age evidence from high resolution epicardial mapping |
| topic | Unipolar atrial electrogram ageing coronary artery bypass grafting sinus rhythm epicardial mapping |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2193426 |
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