The content of adipokines in women with hypothyroidism and type 2 diabetes mellitus
Introduction. Type 2 diabetes mellitus (DM) and hypothyroidism are the most common endocrine pathologies. These diseases are associated with atherogenic dyslipidemia, insulin resistance, and overweight.Aim. Тo assess the relationship between adipokines and hormone-metabolic parameters in women with...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2021-01-01
|
| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/5981 |
| _version_ | 1797841509669666816 |
|---|---|
| author | A. F. Verbovoy T. V. Lomonova |
| author_facet | A. F. Verbovoy T. V. Lomonova |
| author_sort | A. F. Verbovoy |
| collection | DOAJ |
| description | Introduction. Type 2 diabetes mellitus (DM) and hypothyroidism are the most common endocrine pathologies. These diseases are associated with atherogenic dyslipidemia, insulin resistance, and overweight.Aim. Тo assess the relationship between adipokines and hormone-metabolic parameters in women with hypothyroidism, type 2 diabetes mellitus and their combination.Materials and methods. We examined 119 women aged 45 to 74 years: 42 women with primary hypothyroidism, 38 women with type 2 diabetes and 39 women with a combination of type 2 diabetes and hypothyroidism. All patients underwent an anthropometric examination, studied the indicators of lipid and carbohydrate metabolism, the content of adiponectin, leptin and resistin.Results. In women with type 2 diabetes and its combination with hypothyroidism, hyperglycemia, hyperinsulinemia, and insulin resistance were revealed. In all groups, an increase in total cholesterol, triglycerides, atherogenic coefficient was found. The examined women with a combination of hypothyroidism and type 2 diabetes mellitus had a decreased level of adiponectin and an increased level of leptin. In patients with hypothyroidism and patients with type 2 diabetes, a decrease in adiponectin levels and an increase in leptin and resistin were revealed.Discussion. The most pronounced hyperinsulinemia and insulin resistance were found in the group of patients with a combination of hypothyroidism and type 2 diabetes. At the same time, the combination of type 2 diabetes and hypothyroidism in the examined women, according to our data, did not aggravate lipid metabolism disorders. Against the background of visceral obesity in women with a combination of diseases, hypoadiponectinemia and hyperleptinemia were most pronounced. In this group, the level of resistin was positively correlated with the level of insulin and the index of insulin resistance.Conclusion. In women with hypothyroidism, type 2 diabetes and their combination, atherogenic dyslipidemia, hyperleptinemia, and hypoadiponectinemia were established. Hypoadiponectinemia and hyperleptinemia are involved in the development of atherogenic dyslipidemia in women with primary hypothyroidism. |
| first_indexed | 2024-04-09T16:31:59Z |
| format | Article |
| id | doaj.art-92a2405c24ae4b4e977699528361d90e |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:31:59Z |
| publishDate | 2021-01-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-92a2405c24ae4b4e977699528361d90e2023-04-23T06:57:03ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902021-01-0102117017710.21518/2079-701X-2020-21-170-1775444The content of adipokines in women with hypothyroidism and type 2 diabetes mellitusA. F. Verbovoy0T. V. Lomonova1Samara State Medical UniversitySamara State Medical UniversityIntroduction. Type 2 diabetes mellitus (DM) and hypothyroidism are the most common endocrine pathologies. These diseases are associated with atherogenic dyslipidemia, insulin resistance, and overweight.Aim. Тo assess the relationship between adipokines and hormone-metabolic parameters in women with hypothyroidism, type 2 diabetes mellitus and their combination.Materials and methods. We examined 119 women aged 45 to 74 years: 42 women with primary hypothyroidism, 38 women with type 2 diabetes and 39 women with a combination of type 2 diabetes and hypothyroidism. All patients underwent an anthropometric examination, studied the indicators of lipid and carbohydrate metabolism, the content of adiponectin, leptin and resistin.Results. In women with type 2 diabetes and its combination with hypothyroidism, hyperglycemia, hyperinsulinemia, and insulin resistance were revealed. In all groups, an increase in total cholesterol, triglycerides, atherogenic coefficient was found. The examined women with a combination of hypothyroidism and type 2 diabetes mellitus had a decreased level of adiponectin and an increased level of leptin. In patients with hypothyroidism and patients with type 2 diabetes, a decrease in adiponectin levels and an increase in leptin and resistin were revealed.Discussion. The most pronounced hyperinsulinemia and insulin resistance were found in the group of patients with a combination of hypothyroidism and type 2 diabetes. At the same time, the combination of type 2 diabetes and hypothyroidism in the examined women, according to our data, did not aggravate lipid metabolism disorders. Against the background of visceral obesity in women with a combination of diseases, hypoadiponectinemia and hyperleptinemia were most pronounced. In this group, the level of resistin was positively correlated with the level of insulin and the index of insulin resistance.Conclusion. In women with hypothyroidism, type 2 diabetes and their combination, atherogenic dyslipidemia, hyperleptinemia, and hypoadiponectinemia were established. Hypoadiponectinemia and hyperleptinemia are involved in the development of atherogenic dyslipidemia in women with primary hypothyroidism.https://www.med-sovet.pro/jour/article/view/5981adipokinesinsulin resistanceatherogenic dyslipidemiatype 2 diabeteshypothyroidism |
| spellingShingle | A. F. Verbovoy T. V. Lomonova The content of adipokines in women with hypothyroidism and type 2 diabetes mellitus Медицинский совет adipokines insulin resistance atherogenic dyslipidemia type 2 diabetes hypothyroidism |
| title | The content of adipokines in women with hypothyroidism and type 2 diabetes mellitus |
| title_full | The content of adipokines in women with hypothyroidism and type 2 diabetes mellitus |
| title_fullStr | The content of adipokines in women with hypothyroidism and type 2 diabetes mellitus |
| title_full_unstemmed | The content of adipokines in women with hypothyroidism and type 2 diabetes mellitus |
| title_short | The content of adipokines in women with hypothyroidism and type 2 diabetes mellitus |
| title_sort | content of adipokines in women with hypothyroidism and type 2 diabetes mellitus |
| topic | adipokines insulin resistance atherogenic dyslipidemia type 2 diabetes hypothyroidism |
| url | https://www.med-sovet.pro/jour/article/view/5981 |
| work_keys_str_mv | AT afverbovoy thecontentofadipokinesinwomenwithhypothyroidismandtype2diabetesmellitus AT tvlomonova thecontentofadipokinesinwomenwithhypothyroidismandtype2diabetesmellitus AT afverbovoy contentofadipokinesinwomenwithhypothyroidismandtype2diabetesmellitus AT tvlomonova contentofadipokinesinwomenwithhypothyroidismandtype2diabetesmellitus |