Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm
Candida albicans (C. albicans) is the most frequent strain associated with cross-kingdom infections in the oral cavity. Clinical evidence shows the co-existence of Streptococcus mutans (S. mutans) and C. albicans in the carious lesions especially in children with early childhood caries (ECC) and dem...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1106231/full |
| _version_ | 1797828877827964928 |
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| author | Yijun Li Yijun Li Shan Huang Jingyun Du Minjing Wu Xiaojing Huang |
| author_facet | Yijun Li Yijun Li Shan Huang Jingyun Du Minjing Wu Xiaojing Huang |
| author_sort | Yijun Li |
| collection | DOAJ |
| description | Candida albicans (C. albicans) is the most frequent strain associated with cross-kingdom infections in the oral cavity. Clinical evidence shows the co-existence of Streptococcus mutans (S. mutans) and C. albicans in the carious lesions especially in children with early childhood caries (ECC) and demonstrates the close interaction between them. During the interaction, both S. mutans and C. albicans have evolved a complex network of regulatory mechanisms to boost cariogenic virulence and modulate tolerance upon stress changes in the external environment. The intricate relationship and unpredictable consequences pose great therapeutic challenges in clinics, which indicate the demand for de novo emergence of potential antimicrobial therapy with multi-targets or combinatorial therapies. In this article, we present an overview of the clinical significance, and cooperative network of the cross-kingdom interaction between S. mutans and C. albicans. Furthermore, we also summarize the current strategies for targeting cross-kingdom biofilm. |
| first_indexed | 2024-04-09T13:11:26Z |
| format | Article |
| id | doaj.art-92a2d3ff993b4107abb42e1c61e4c08a |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-09T13:11:26Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-92a2d3ff993b4107abb42e1c61e4c08a2023-05-12T07:03:30ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-05-011310.3389/fcimb.2023.11062311106231Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilmYijun Li0Yijun Li1Shan Huang2Jingyun Du3Minjing Wu4Xiaojing Huang5Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaDepartment of Endodontics, Stomatological Hospital of Xiamen Medical College, Xiamen, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaStomatological Hospital, Southern Medical University, Guangzhou, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaCandida albicans (C. albicans) is the most frequent strain associated with cross-kingdom infections in the oral cavity. Clinical evidence shows the co-existence of Streptococcus mutans (S. mutans) and C. albicans in the carious lesions especially in children with early childhood caries (ECC) and demonstrates the close interaction between them. During the interaction, both S. mutans and C. albicans have evolved a complex network of regulatory mechanisms to boost cariogenic virulence and modulate tolerance upon stress changes in the external environment. The intricate relationship and unpredictable consequences pose great therapeutic challenges in clinics, which indicate the demand for de novo emergence of potential antimicrobial therapy with multi-targets or combinatorial therapies. In this article, we present an overview of the clinical significance, and cooperative network of the cross-kingdom interaction between S. mutans and C. albicans. Furthermore, we also summarize the current strategies for targeting cross-kingdom biofilm.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1106231/fullbiofilmCandida albicansStreptococcus mutanscross-kingdom interactiontherapeutic strategies |
| spellingShingle | Yijun Li Yijun Li Shan Huang Jingyun Du Minjing Wu Xiaojing Huang Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm Frontiers in Cellular and Infection Microbiology biofilm Candida albicans Streptococcus mutans cross-kingdom interaction therapeutic strategies |
| title | Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm |
| title_full | Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm |
| title_fullStr | Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm |
| title_full_unstemmed | Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm |
| title_short | Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm |
| title_sort | current and prospective therapeutic strategies tackling candida albicans and streptococcus mutans cross kingdom biofilm |
| topic | biofilm Candida albicans Streptococcus mutans cross-kingdom interaction therapeutic strategies |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1106231/full |
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