Single‐Cell Transcriptomics Reveals Longevity Immune Remodeling Features Shared by Centenarians and Their Offspring

Single‐Cell Transcriptomics Reveals Longevity Immune Remodeling Features Shared by Centenarians and Their Offspring

Abstract Centenarians, who show mild infections and low incidence of tumors, are the optimal model to investigate healthy aging. However, longevity related immune characteristics has not been fully revealed largely due to lack of appropriate controls. In this study, single‐cell transcriptomic analys...

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Bibliographic Details
Main Authors: Chen Dong, Ya‐ru Miao, Rui Zhao, Mei Yang, An‐yuan Guo, Zhong‐hui Xue, Teng Li, Qiong Zhang, Yanfeng Bao, Chen Shen, Chi Sun, Ying Yang, Xi‐xi Gu, Yi Jin, Rong Li, Min Xu, Jia‐xin Guo, Zhi‐ying Zong, Wei Zhou, Mei He, Dan‐ni Wang, Jian‐you Su, Xiao‐ming Zhang, Xu‐hui Zeng, Jian‐lin Gao, Zhi‐feng Gu
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Advanced Science
Subjects:
centenarian
immune remodeling
longevity
single‐cell transcriptome
T cell
Online Access:https://doi.org/10.1002/advs.202204849

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