Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.
Human Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-09-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1009352 |
| _version_ | 1819176255156649984 |
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| author | Thomas Beneteau Christian Selinger Mircea T Sofonea Samuel Alizon |
| author_facet | Thomas Beneteau Christian Selinger Mircea T Sofonea Samuel Alizon |
| author_sort | Thomas Beneteau |
| collection | DOAJ |
| description | Human Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still poorly known. Building on earlier work stressing the importance of randomness in the type of cell divisions in the clearance of HPV infection, we develop a stochastic mathematical model of HPV dynamics that combines the previous aspect with an explicit description of the intracellular level. We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions dramatically affect viral persistence. These results call for more detailed within-host studies to better understand the relative importance of stochasticity and immunity in HPV infection clearance. |
| first_indexed | 2024-12-22T21:07:51Z |
| format | Article |
| id | doaj.art-92a308c82fe04712a9b319a4c1ca9944 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-22T21:07:51Z |
| publishDate | 2021-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-92a308c82fe04712a9b319a4c1ca99442022-12-21T18:12:37ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-09-01179e100935210.1371/journal.pcbi.1009352Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.Thomas BeneteauChristian SelingerMircea T SofoneaSamuel AlizonHuman Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still poorly known. Building on earlier work stressing the importance of randomness in the type of cell divisions in the clearance of HPV infection, we develop a stochastic mathematical model of HPV dynamics that combines the previous aspect with an explicit description of the intracellular level. We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions dramatically affect viral persistence. These results call for more detailed within-host studies to better understand the relative importance of stochasticity and immunity in HPV infection clearance.https://doi.org/10.1371/journal.pcbi.1009352 |
| spellingShingle | Thomas Beneteau Christian Selinger Mircea T Sofonea Samuel Alizon Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections. PLoS Computational Biology |
| title | Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections. |
| title_full | Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections. |
| title_fullStr | Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections. |
| title_full_unstemmed | Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections. |
| title_short | Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections. |
| title_sort | episome partitioning and symmetric cell divisions quantifying the role of random events in the persistence of hpv infections |
| url | https://doi.org/10.1371/journal.pcbi.1009352 |
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