Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors
Summary: Design of tissue-specific contrast agents to delineate tumors from background tissues is a major unmet clinical need for ultimate surgical interventions. Bioconjugation of fluorophore(s) to a ligand has been mainly used to target overexpressed receptors on tumors. However, the size of the f...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220301905 |
| _version_ | 1819133890513600512 |
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| author | G. Kate Park Jeong Heon Lee Eduardo Soriano Myunghwan Choi Kai Bao Wataru Katagiri Do-Yeon Kim Ji-Hye Paik Seok-Hyun Yun John V. Frangioni Thomas E. Clancy Satoshi Kashiwagi Maged Henary Hak Soo Choi |
| author_facet | G. Kate Park Jeong Heon Lee Eduardo Soriano Myunghwan Choi Kai Bao Wataru Katagiri Do-Yeon Kim Ji-Hye Paik Seok-Hyun Yun John V. Frangioni Thomas E. Clancy Satoshi Kashiwagi Maged Henary Hak Soo Choi |
| author_sort | G. Kate Park |
| collection | DOAJ |
| description | Summary: Design of tissue-specific contrast agents to delineate tumors from background tissues is a major unmet clinical need for ultimate surgical interventions. Bioconjugation of fluorophore(s) to a ligand has been mainly used to target overexpressed receptors on tumors. However, the size of the final targeted ligand can be large, >20 kDa, and cannot readily cross the microvasculature to meet the specific tissue, resulting in low targetability with a high background. Here, we report a small and hydrophilic phenoxazine with high targetability and retention to pancreatic neuroendocrine tumor. This bioengineered fluorophore permits sensitive detection of ultrasmall (<0.5 mm) ectopic tumors within a few seconds after a single bolus injection, highlighting every tumor in the pancreas from the surrounding healthy tissues with reasonable half-life. The knowledge-based approach and validation used to develop structure-inherent tumor-targeted fluorophores have a tremendous potential to improve treatment outcome by providing definite tumor margins for image-guided surgery. : Histology; Chemistry; Cancer Subject Areas: Histology, Chemistry, Cancer |
| first_indexed | 2024-12-22T09:54:29Z |
| format | Article |
| id | doaj.art-92a3fc2c2d484fb8be56db98517e7163 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-22T09:54:29Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-92a3fc2c2d484fb8be56db98517e71632022-12-21T18:30:18ZengElsevieriScience2589-00422020-04-01234Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine TumorsG. Kate Park0Jeong Heon Lee1Eduardo Soriano2Myunghwan Choi3Kai Bao4Wataru Katagiri5Do-Yeon Kim6Ji-Hye Paik7Seok-Hyun Yun8John V. Frangioni9Thomas E. Clancy10Satoshi Kashiwagi11Maged Henary12Hak Soo Choi13Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USAGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USADepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 100 Piedmont Ave SE, Atlanta, Georgia 30303, USAWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, MA 02139, USAGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USAGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USADepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USADepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USAWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, MA 02139, USACuradel, LLC, Natick, MA 01760, USADivision of Surgical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA 02215, USAGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USADepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 100 Piedmont Ave SE, Atlanta, Georgia 30303, USA; Corresponding authorGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Corresponding authorSummary: Design of tissue-specific contrast agents to delineate tumors from background tissues is a major unmet clinical need for ultimate surgical interventions. Bioconjugation of fluorophore(s) to a ligand has been mainly used to target overexpressed receptors on tumors. However, the size of the final targeted ligand can be large, >20 kDa, and cannot readily cross the microvasculature to meet the specific tissue, resulting in low targetability with a high background. Here, we report a small and hydrophilic phenoxazine with high targetability and retention to pancreatic neuroendocrine tumor. This bioengineered fluorophore permits sensitive detection of ultrasmall (<0.5 mm) ectopic tumors within a few seconds after a single bolus injection, highlighting every tumor in the pancreas from the surrounding healthy tissues with reasonable half-life. The knowledge-based approach and validation used to develop structure-inherent tumor-targeted fluorophores have a tremendous potential to improve treatment outcome by providing definite tumor margins for image-guided surgery. : Histology; Chemistry; Cancer Subject Areas: Histology, Chemistry, Cancerhttp://www.sciencedirect.com/science/article/pii/S2589004220301905 |
| spellingShingle | G. Kate Park Jeong Heon Lee Eduardo Soriano Myunghwan Choi Kai Bao Wataru Katagiri Do-Yeon Kim Ji-Hye Paik Seok-Hyun Yun John V. Frangioni Thomas E. Clancy Satoshi Kashiwagi Maged Henary Hak Soo Choi Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors iScience |
| title | Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors |
| title_full | Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors |
| title_fullStr | Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors |
| title_full_unstemmed | Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors |
| title_short | Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors |
| title_sort | rapid and selective targeting of heterogeneous pancreatic neuroendocrine tumors |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220301905 |
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