REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS
The paper presents evidence that the individuals with different blood groups and glucose levels exhibit individual IgE reagin responses to insulin. Thus, the persons with 0 (I) blood group showed the highest values of anti-insulin-specific IgE (124.83±67.9 kE/L) when their glucose level was under 4...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2018-06-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1567 |
| _version_ | 1797197960038055936 |
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| author | N. R. Telesmanich M. A. Konovalchik Z. I. Mikashinovich E. G. Krivolapova |
| author_facet | N. R. Telesmanich M. A. Konovalchik Z. I. Mikashinovich E. G. Krivolapova |
| author_sort | N. R. Telesmanich |
| collection | DOAJ |
| description | The paper presents evidence that the individuals with different blood groups and glucose levels exhibit individual IgE reagin responses to insulin. Thus, the persons with 0 (I) blood group showed the highest values of anti-insulin-specific IgE (124.83±67.9 kE/L) when their glucose level was under 4 mmol/l. Such values are characteristic to the patients with A (II) and B (III) blood groups with normal glucose levels. Among subjects with B (III) blood group showing decreased glucose values (< 4 mmol/L), the lowest insulin induction (0.85±0.05 mkE/ml) was observed, and the IgE production to insulin increased 80-fold, reaching 113.0±56.0 kE/L. At the first ("borderline") stage of carbohydrate metabolism disorders (glucose levels 6.0 to 7.6 mmol/L), the insulin production is increased 3-fold in 0 (I) and A (II) blood groups, whereas insulin levels in persons with B(III) blood group are near-normal (12.3±3.7), and IgE antibodies to insulin show lowest levels (27.2±9.08 kE/L), thus being 5 times lower when compared to the persons with B (III) blood group. However, carriers of all three group antigens and patients with expressed type 2 diabetes respond to increased glucose and insulin levels in blood by decreased production of specific IgE antibodies to insulin. |
| first_indexed | 2024-03-08T05:48:53Z |
| format | Article |
| id | doaj.art-92a4349411a54d34a5f6efa0c373778b |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:52:15Z |
| publishDate | 2018-06-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-92a4349411a54d34a5f6efa0c373778b2024-04-22T13:07:43ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2018-06-0120458959610.15789/1563-0625-2018-4-589-5961034REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTSN. R. Telesmanich0M. A. Konovalchik1Z. I. Mikashinovich2E. G. Krivolapova3Rostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityThe paper presents evidence that the individuals with different blood groups and glucose levels exhibit individual IgE reagin responses to insulin. Thus, the persons with 0 (I) blood group showed the highest values of anti-insulin-specific IgE (124.83±67.9 kE/L) when their glucose level was under 4 mmol/l. Such values are characteristic to the patients with A (II) and B (III) blood groups with normal glucose levels. Among subjects with B (III) blood group showing decreased glucose values (< 4 mmol/L), the lowest insulin induction (0.85±0.05 mkE/ml) was observed, and the IgE production to insulin increased 80-fold, reaching 113.0±56.0 kE/L. At the first ("borderline") stage of carbohydrate metabolism disorders (glucose levels 6.0 to 7.6 mmol/L), the insulin production is increased 3-fold in 0 (I) and A (II) blood groups, whereas insulin levels in persons with B(III) blood group are near-normal (12.3±3.7), and IgE antibodies to insulin show lowest levels (27.2±9.08 kE/L), thus being 5 times lower when compared to the persons with B (III) blood group. However, carriers of all three group antigens and patients with expressed type 2 diabetes respond to increased glucose and insulin levels in blood by decreased production of specific IgE antibodies to insulin.https://www.mimmun.ru/mimmun/article/view/1567specific igeigeantibodiesblood group (ab0)antigenic determinantsdiabetescarbohydrate metabolism disordersinsulin |
| spellingShingle | N. R. Telesmanich M. A. Konovalchik Z. I. Mikashinovich E. G. Krivolapova REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS Медицинская иммунология specific ige ige antibodies blood group (ab0) antigenic determinants diabetes carbohydrate metabolism disorders insulin |
| title | REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS |
| title_full | REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS |
| title_fullStr | REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS |
| title_full_unstemmed | REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS |
| title_short | REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS |
| title_sort | reagin specific response to insulin level in carbohydrate metabolism disorders is dependent on the blood group abo antigenic determinants |
| topic | specific ige ige antibodies blood group (ab0) antigenic determinants diabetes carbohydrate metabolism disorders insulin |
| url | https://www.mimmun.ru/mimmun/article/view/1567 |
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