The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells. A subset of integrins that recognize the arginyl–glycyl–aspartic aci...

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Bibliographic Details
Main Authors: Eun Jeong Park, Phyoe Kyawe Myint, Michael Gyasi Appiah, Samuel Darkwah, Siqingaowa Caidengbate, Atsushi Ito, Eri Matsuo, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
SARS-CoV-2
spike 1 protein
angiotensin-converting enzyme 2
integrin
cell adhesion
alveolar epithelial cells
Online Access:https://www.mdpi.com/1999-4915/13/4/645

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