Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration

Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration

The nitric oxide – guanylyl cyclase-1 – cyclic guanylate monophosphate (NO-GC-1–cGMP) pathway has emerged as a potential pathogenic mechanism for glaucoma, a common intraocular pressure (IOP)-related optic neuropathy characterized by the degeneration of retinal ganglion cells (RGCs) and their axons...

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Bibliographic Details
Main Authors: Lauren K. Wareham, Ana C. Dordea, Grigorij Schleifer, Vincent Yao, Annabelle Batten, Fei Fei, Joseph Mertz, Meredith Gregory-Ksander, Louis R. Pasquale, Emmanuel S. Buys, Rebecca M. Sappington
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Neurobiology of Disease
Subjects:
cGMP
Retinal ganglion cell
Glaucoma
Nitric oxide
PDE5
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611830202X

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