Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases
NADH:ubiquinone oxidoreductase core subunit S8 (NDUFS8) is an essential core subunit and component of the iron-sulfur (FeS) fragment of mitochondrial complex I directly involved in the electron transfer process and energy metabolism. Pathogenic variants of the <i>NDUFS8</i> are relevant...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/24/8754 |
| _version_ | 1797456092306866176 |
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| author | Sifan Wang Yuanbo Kang Ruifeng Wang Junqi Deng Yupei Yu Jun Yu Junpu Wang |
| author_facet | Sifan Wang Yuanbo Kang Ruifeng Wang Junqi Deng Yupei Yu Jun Yu Junpu Wang |
| author_sort | Sifan Wang |
| collection | DOAJ |
| description | NADH:ubiquinone oxidoreductase core subunit S8 (NDUFS8) is an essential core subunit and component of the iron-sulfur (FeS) fragment of mitochondrial complex I directly involved in the electron transfer process and energy metabolism. Pathogenic variants of the <i>NDUFS8</i> are relevant to infantile-onset and severe diseases, including Leigh syndrome, cancer, and diabetes mellitus. With over 1000 nuclear genes potentially causing a mitochondrial disorder, the current diagnostic approach requires targeted molecular analysis, guided by a combination of clinical and biochemical features. Currently, there are only several studies on pathogenic variants of the <i>NDUFS8</i> in Leigh syndrome, and a lack of literature on its precise mechanism in cancer and diabetes mellitus exists. Therefore, NDUFS8-related diseases should be extensively explored and precisely diagnosed at the molecular level with the application of next-generation sequencing technologies. A more distinct comprehension will be needed to shed light on NDUFS8 and its related diseases for further research. In this review, a comprehensive summary of the current knowledge about NDUFS8 structural function, its pathogenic mutations in Leigh syndrome, as well as its underlying roles in cancer and diabetes mellitus is provided, offering potential pathogenesis, progress, and therapeutic target of different diseases. We also put forward some problems and solutions for the following investigations. |
| first_indexed | 2024-03-09T16:03:26Z |
| format | Article |
| id | doaj.art-92a5034a03214b508fec846ed56e68da |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T16:03:26Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-92a5034a03214b508fec846ed56e68da2023-11-24T16:56:52ZengMDPI AGMolecules1420-30492022-12-012724875410.3390/molecules27248754Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different DiseasesSifan Wang0Yuanbo Kang1Ruifeng Wang2Junqi Deng3Yupei Yu4Jun Yu5Junpu Wang6Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Neurology, Third Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaNADH:ubiquinone oxidoreductase core subunit S8 (NDUFS8) is an essential core subunit and component of the iron-sulfur (FeS) fragment of mitochondrial complex I directly involved in the electron transfer process and energy metabolism. Pathogenic variants of the <i>NDUFS8</i> are relevant to infantile-onset and severe diseases, including Leigh syndrome, cancer, and diabetes mellitus. With over 1000 nuclear genes potentially causing a mitochondrial disorder, the current diagnostic approach requires targeted molecular analysis, guided by a combination of clinical and biochemical features. Currently, there are only several studies on pathogenic variants of the <i>NDUFS8</i> in Leigh syndrome, and a lack of literature on its precise mechanism in cancer and diabetes mellitus exists. Therefore, NDUFS8-related diseases should be extensively explored and precisely diagnosed at the molecular level with the application of next-generation sequencing technologies. A more distinct comprehension will be needed to shed light on NDUFS8 and its related diseases for further research. In this review, a comprehensive summary of the current knowledge about NDUFS8 structural function, its pathogenic mutations in Leigh syndrome, as well as its underlying roles in cancer and diabetes mellitus is provided, offering potential pathogenesis, progress, and therapeutic target of different diseases. We also put forward some problems and solutions for the following investigations.https://www.mdpi.com/1420-3049/27/24/8754NDUFS8mitochondrial complex ILeigh syndromecancerdiabetes mellitusmetabolism |
| spellingShingle | Sifan Wang Yuanbo Kang Ruifeng Wang Junqi Deng Yupei Yu Jun Yu Junpu Wang Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases Molecules NDUFS8 mitochondrial complex I Leigh syndrome cancer diabetes mellitus metabolism |
| title | Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases |
| title_full | Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases |
| title_fullStr | Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases |
| title_full_unstemmed | Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases |
| title_short | Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases |
| title_sort | emerging roles of ndufs8 located in mitochondrial complex i in different diseases |
| topic | NDUFS8 mitochondrial complex I Leigh syndrome cancer diabetes mellitus metabolism |
| url | https://www.mdpi.com/1420-3049/27/24/8754 |
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