LC3/FtMt Colocalization Patterns Reveal the Progression of FtMt Accumulation in Nigral Neurons of Patients with Progressive Supranuclear Palsy

LC3/FtMt Colocalization Patterns Reveal the Progression of FtMt Accumulation in Nigral Neurons of Patients with Progressive Supranuclear Palsy

Mitochondrial ferritin (FtMt) is a mitochondrial iron storage protein associated with neurodegenerative diseases. In patients with progressive supranuclear palsy (PSP), FtMt was shown to accumulate in nigral neurons. Here, we investigated FtMt and LC3 in the post-mortem midbrain of PSP patients to r...

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Bibliographic Details
Main Authors: Zulzikry Hafiz Abu Bakar, Jean-Pierre Bellier, Daijiro Yanagisawa, Tomoko Kato, Ken-ichi Mukaisho, Ikuo Tooyama
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
progressive supranuclear palsy
mitochondrial ferritin
FtMt
LC3
mitophagy
midbrain
Online Access:https://www.mdpi.com/1422-0067/23/1/537

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