Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity. A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disorder...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Neuroinformatics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fninf.2019.00078/full |
| _version_ | 1819020816354902016 |
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| author | Francesca Mandino Francesca Mandino Domenic H. Cerri Clement M. Garin Clement M. Garin Milou Straathof Geralda A. F. van Tilborg M. Mallar Chakravarty M. Mallar Chakravarty Marc Dhenain Marc Dhenain Rick M. Dijkhuizen Alessandro Gozzi Andreas Hess Shella D. Keilholz Jason P. Lerch Jason P. Lerch Yen-Yu Ian Shih Joanes Grandjean Joanes Grandjean |
| author_facet | Francesca Mandino Francesca Mandino Domenic H. Cerri Clement M. Garin Clement M. Garin Milou Straathof Geralda A. F. van Tilborg M. Mallar Chakravarty M. Mallar Chakravarty Marc Dhenain Marc Dhenain Rick M. Dijkhuizen Alessandro Gozzi Andreas Hess Shella D. Keilholz Jason P. Lerch Jason P. Lerch Yen-Yu Ian Shih Joanes Grandjean Joanes Grandjean |
| author_sort | Francesca Mandino |
| collection | DOAJ |
| description | Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity. A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disordered brain. Animal fMRI studies have developed rapidly over the past years, fueled by the development of resting-state fMRI connectivity and genetically encoded neuromodulatory tools. Yet, comparisons between sites remain hampered by lack of standardization. Recently, we highlighted that mouse resting-state functional connectivity converges across centers, although large discrepancies in sensitivity and specificity remained. Here, we explore past and present trends within the animal fMRI community and highlight critical aspects in study design, data acquisition, and post-processing operations, that may affect the results and influence the comparability between studies. We also suggest practices aimed to promote the adoption of standards within the community and improve between-lab reproducibility. The implementation of standardized animal neuroimaging protocols will facilitate animal population imaging efforts as well as meta-analysis and replication studies, the gold standards in evidence-based science. |
| first_indexed | 2024-12-21T03:57:13Z |
| format | Article |
| id | doaj.art-92a5cbc7ebb04e178c01fe48db3b3d3a |
| institution | Directory Open Access Journal |
| issn | 1662-5196 |
| language | English |
| last_indexed | 2024-12-21T03:57:13Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroinformatics |
| spelling | doaj.art-92a5cbc7ebb04e178c01fe48db3b3d3a2022-12-21T19:16:48ZengFrontiers Media S.A.Frontiers in Neuroinformatics1662-51962020-01-011310.3389/fninf.2019.00078475219Animal Functional Magnetic Resonance Imaging: Trends and Path Toward StandardizationFrancesca Mandino0Francesca Mandino1Domenic H. Cerri2Clement M. Garin3Clement M. Garin4Milou Straathof5Geralda A. F. van Tilborg6M. Mallar Chakravarty7M. Mallar Chakravarty8Marc Dhenain9Marc Dhenain10Rick M. Dijkhuizen11Alessandro Gozzi12Andreas Hess13Shella D. Keilholz14Jason P. Lerch15Jason P. Lerch16Yen-Yu Ian Shih17Joanes Grandjean18Joanes Grandjean19Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, SingaporeFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, United KingdomCenter for Animal MRI, Department of Neurology, Biomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDirection de la Recherche Fondamentale, MIRCen, Institut de Biologie François Jacob, Commissariat à l’Énergie Atomique et aux Énergies Alternatives, Fontenay-aux-Roses, FranceNeurodegenerative Diseases Laboratory, Centre National de la Recherche Scientifique, UMR 9199, Université Paris-Sud, Université Paris-Saclay, Fontenay-aux-Roses, FranceBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, CanadaDepartment of Biological and Biomedical Engineering, Douglas Mental Health University Institute, McGill University, Montreal, QC, CanadaDirection de la Recherche Fondamentale, MIRCen, Institut de Biologie François Jacob, Commissariat à l’Énergie Atomique et aux Énergies Alternatives, Fontenay-aux-Roses, FranceNeurodegenerative Diseases Laboratory, Centre National de la Recherche Scientifique, UMR 9199, Université Paris-Sud, Université Paris-Saclay, Fontenay-aux-Roses, FranceBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsFunctional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Systems @ UNITN, Rovereto, Italy0Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich–Alexander University Erlangen–Nürnberg, Erlangen, Germany1Department of Biomedical Engineering, Georgia Tech, Emory University, Atlanta, GA, United States2Hospital for Sick Children, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada3Wellcome Centre for Integrative NeuroImaging, University of Oxford, Oxford, United KingdomCenter for Animal MRI, Department of Neurology, Biomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesSingapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore4Department of Radiology and Nuclear Medicine, Donders Institute for Brain, Cognition, and Behaviour, Donders Institute, Radboud University Medical Center, Nijmegen, NetherlandsAnimal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity. A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disordered brain. Animal fMRI studies have developed rapidly over the past years, fueled by the development of resting-state fMRI connectivity and genetically encoded neuromodulatory tools. Yet, comparisons between sites remain hampered by lack of standardization. Recently, we highlighted that mouse resting-state functional connectivity converges across centers, although large discrepancies in sensitivity and specificity remained. Here, we explore past and present trends within the animal fMRI community and highlight critical aspects in study design, data acquisition, and post-processing operations, that may affect the results and influence the comparability between studies. We also suggest practices aimed to promote the adoption of standards within the community and improve between-lab reproducibility. The implementation of standardized animal neuroimaging protocols will facilitate animal population imaging efforts as well as meta-analysis and replication studies, the gold standards in evidence-based science.https://www.frontiersin.org/article/10.3389/fninf.2019.00078/fullresting-staterodentnon-human primateoptogeneticsDREADD |
| spellingShingle | Francesca Mandino Francesca Mandino Domenic H. Cerri Clement M. Garin Clement M. Garin Milou Straathof Geralda A. F. van Tilborg M. Mallar Chakravarty M. Mallar Chakravarty Marc Dhenain Marc Dhenain Rick M. Dijkhuizen Alessandro Gozzi Andreas Hess Shella D. Keilholz Jason P. Lerch Jason P. Lerch Yen-Yu Ian Shih Joanes Grandjean Joanes Grandjean Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization Frontiers in Neuroinformatics resting-state rodent non-human primate optogenetics DREADD |
| title | Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization |
| title_full | Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization |
| title_fullStr | Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization |
| title_full_unstemmed | Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization |
| title_short | Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization |
| title_sort | animal functional magnetic resonance imaging trends and path toward standardization |
| topic | resting-state rodent non-human primate optogenetics DREADD |
| url | https://www.frontiersin.org/article/10.3389/fninf.2019.00078/full |
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