Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate
Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, an...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-03-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622000494 |
| _version_ | 1798024217653936128 |
|---|---|
| author | Bo Song Zhendong Qiu Mingxue Li Tingting Luo Qi Wu Hari B. Krishnan Junjiang Wu Pengfei Xu Shuzhen Zhang Shanshan Liu |
| author_facet | Bo Song Zhendong Qiu Mingxue Li Tingting Luo Qi Wu Hari B. Krishnan Junjiang Wu Pengfei Xu Shuzhen Zhang Shanshan Liu |
| author_sort | Bo Song |
| collection | DOAJ |
| description | Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF. |
| first_indexed | 2024-04-11T17:58:50Z |
| format | Article |
| id | doaj.art-92a66b5ff9e948ce907fab64a44b487c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-11T17:58:50Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-92a66b5ff9e948ce907fab64a44b487c2022-12-22T04:10:35ZengElsevierJournal of Functional Foods1756-46462022-03-0190104979Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrateBo Song0Zhendong Qiu1Mingxue Li2Tingting Luo3Qi Wu4Hari B. Krishnan5Junjiang Wu6Pengfei Xu7Shuzhen Zhang8Shanshan Liu9Soybean Research Institute, Northeast Agricultural University/Key Laboratory of Soybean Biology of the Chinese Education Ministry, Harbin 150030, ChinaSoybean Research Institute, Northeast Agricultural University/Key Laboratory of Soybean Biology of the Chinese Education Ministry, Harbin 150030, ChinaSoybean Research Institute, Northeast Agricultural University/Key Laboratory of Soybean Biology of the Chinese Education Ministry, Harbin 150030, ChinaSoybean Research Institute, Northeast Agricultural University/Key Laboratory of Soybean Biology of the Chinese Education Ministry, Harbin 150030, ChinaSoybean Research Institute of Heilongjiang Academy of Agricultural Sciences/Key Laboratory of Soybean Cultivation, Ministry of Agriculture and Rural Affairs, Harbin 150086, ChinaPlant Genetics Research, USDA Agricultural Research Service, Columbia, MO 65211, USA; Plant Science Division, University of Missouri, Columbia, MO, USAHeilongjiang Seed Industry Technical Service Center, Harbin 150008, ChinaSoybean Research Institute, Northeast Agricultural University/Key Laboratory of Soybean Biology of the Chinese Education Ministry, Harbin 150030, ChinaSoybean Research Institute, Northeast Agricultural University/Key Laboratory of Soybean Biology of the Chinese Education Ministry, Harbin 150030, ChinaSoybean Research Institute, Northeast Agricultural University/Key Laboratory of Soybean Biology of the Chinese Education Ministry, Harbin 150030, China; Corresponding author.Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF.http://www.sciencedirect.com/science/article/pii/S1756464622000494Soybean cultivar ‘DND358’Soy protein isolate beverage powderHypocholesterolemic effectFenofibrate |
| spellingShingle | Bo Song Zhendong Qiu Mingxue Li Tingting Luo Qi Wu Hari B. Krishnan Junjiang Wu Pengfei Xu Shuzhen Zhang Shanshan Liu Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate Journal of Functional Foods Soybean cultivar ‘DND358’ Soy protein isolate beverage powder Hypocholesterolemic effect Fenofibrate |
| title | Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate |
| title_full | Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate |
| title_fullStr | Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate |
| title_full_unstemmed | Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate |
| title_short | Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate |
| title_sort | breeding of dnd358 a new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate |
| topic | Soybean cultivar ‘DND358’ Soy protein isolate beverage powder Hypocholesterolemic effect Fenofibrate |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622000494 |
| work_keys_str_mv | AT bosong breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate AT zhendongqiu breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate AT mingxueli breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate AT tingtingluo breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate AT qiwu breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate AT haribkrishnan breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate AT junjiangwu breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate AT pengfeixu breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate AT shuzhenzhang breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate AT shanshanliu breedingofdnd358anewsoybeancultivarforprocessingsoyproteinisolatewithahypocholesterolemiceffectsimilartothatoffenofibrate |