Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents
Visible spectrophotometric method can be used to determine cefadroxil in the pharmaceutical dosage form. The reaction of cefadroxil with the condensation product of 2 mol ethyl acetoacetate and 1 mol formaldehyde in acidic condition (pH 3,5) at 45°C for 20 minutes yielded yellow product giving absor...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2008-01-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/309 |
| _version_ | 1818147704496193536 |
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| author | Ratna Asmah Susidarti Andrih Rianti Sudibyo Martono |
| author_facet | Ratna Asmah Susidarti Andrih Rianti Sudibyo Martono |
| author_sort | Ratna Asmah Susidarti |
| collection | DOAJ |
| description | Visible spectrophotometric method can be used to determine cefadroxil in the pharmaceutical dosage form. The reaction of cefadroxil with the condensation product of 2 mol ethyl acetoacetate and 1 mol formaldehyde in acidic condition (pH 3,5) at 45°C for 20 minutes yielded yellow product giving absorption at 367 nm. The concentration of Cefadroxil was calculated by using standard curve Y = 1.6063 X + 0.1634, r = 0.9932, p = 0,001 and Vxo = 9,7%. Determination of cefadroxil capsule ”X” (562.4 mg/capsule) showed that the concentration of cefadroxil observed is 490.5 mg/capsule (CV = 0.89%) and recovery value is 102.88% (CV = 0.67%). |
| first_indexed | 2024-12-11T12:39:29Z |
| format | Article |
| id | doaj.art-92a677f3406a4cdfb250e59edd83f037 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-11T12:39:29Z |
| publishDate | 2008-01-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-92a677f3406a4cdfb250e59edd83f0372022-12-22T01:07:02ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862008-01-011914147http://dx.doi.org/10.14499/indonesianjpharm0iss0pp41-47Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagentsRatna Asmah Susidarti0Andrih Rianti1Sudibyo Martono2Bagian Kimia Farmasi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta Bagian Kimia Farmasi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta Bagian Kimia Farmasi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta Visible spectrophotometric method can be used to determine cefadroxil in the pharmaceutical dosage form. The reaction of cefadroxil with the condensation product of 2 mol ethyl acetoacetate and 1 mol formaldehyde in acidic condition (pH 3,5) at 45°C for 20 minutes yielded yellow product giving absorption at 367 nm. The concentration of Cefadroxil was calculated by using standard curve Y = 1.6063 X + 0.1634, r = 0.9932, p = 0,001 and Vxo = 9,7%. Determination of cefadroxil capsule ”X” (562.4 mg/capsule) showed that the concentration of cefadroxil observed is 490.5 mg/capsule (CV = 0.89%) and recovery value is 102.88% (CV = 0.67%).http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/309visible spectrophotometryCefadroxilethyl acetoacetateformaldehyde |
| spellingShingle | Ratna Asmah Susidarti Andrih Rianti Sudibyo Martono Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents Indonesian Journal of Pharmacy visible spectrophotometry Cefadroxil ethyl acetoacetate formaldehyde |
| title | Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents |
| title_full | Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents |
| title_fullStr | Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents |
| title_full_unstemmed | Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents |
| title_short | Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents |
| title_sort | visible spectrophotometric determination of cefadroxil using ethyl acetoacetate and formaldehyde reagents |
| topic | visible spectrophotometry Cefadroxil ethyl acetoacetate formaldehyde |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/309 |
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