Bifunctional crosslinking ligands for transthyretin

Bifunctional crosslinking ligands for transthyretin

Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease. Reduction in the abundance of amyloid fibril precu...

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Bibliographic Details
Main Authors: P. Patrizia Mangione, Stéphanie Deroo, Stephan Ellmerich, Vittorio Bellotti, Simon Kolstoe, Stephen P. Wood, Carol V. Robinson, Martin D. Smith, Glenys A. Tennent, Robert J. Broadbridge, Claire E. Council, Joanne R. Thurston, Victoria A. Steadman, Antonio K. Vong, Christopher J. Swain, Mark B. Pepys, Graham W. Taylor
Format: Article
Language:English
Published: The Royal Society 2015-01-01
Series:Open Biology
Subjects:
amyloidosis
transthyretin
crosslinking
plasma clearance
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150105

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