Structural basis for UFM1 transfer from UBA5 to UFC1
Ufmylation is a well-established ubiquitin-like protein modification, but its mechanism is largely unclear. Here, the authors present a crystal structure of the ufmylation-specific E1-E2 complex, revealing differences to the ubiquitination machinery and mechanistic details of the ufmylation process.
Bibliographic Details
| Main Authors: |
Manoj Kumar,
Prasanth Padala,
Jamal Fahoum,
Fouad Hassouna,
Tomer Tsaban,
Guy Zoltsman,
Sayanika Banerjee,
Einav Cohen-Kfir,
Moshe Dessau,
Rina Rosenzweig,
Michail N. Isupov,
Ora Schueler-Furman,
Reuven Wiener |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-25994-6
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