hUMSC vs. hUMSC–Exosome: Which One Is Better for Epilepsy?
Epilepsy is a disorder characterized by abnormal brain cell activity that results in seizures. It causes progressive damage to neurons. Epilepsy treatment currently focuses mostly on symptoms, which also have risks of unwanted side effects. There is currently no effective treatment to prevent epilep...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/10/1247 |
| _version_ | 1797470472012562432 |
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| author | Sri Hastuti Rinaldi Idroes Imran Imran Yetty Ramli Abdul Hawil Abas Trina Ekawati Tallei |
| author_facet | Sri Hastuti Rinaldi Idroes Imran Imran Yetty Ramli Abdul Hawil Abas Trina Ekawati Tallei |
| author_sort | Sri Hastuti |
| collection | DOAJ |
| description | Epilepsy is a disorder characterized by abnormal brain cell activity that results in seizures. It causes progressive damage to neurons. Epilepsy treatment currently focuses mostly on symptoms, which also have risks of unwanted side effects. There is currently no effective treatment to prevent epileptogenesis and the resulting neural damage. Human Umbilical Cord Mesenchymal Stem Cell (hUMSC) and exosome therapy are examples of cellular therapies that may be used to treat degenerative diseases, such as epilepsy, or cell damage. However, there is still little research on the use of hUMSCs or hUMSC–exosomes for treating epilepsy. Hence, the purpose of this paper is to compare the potential and risk of hUMSCs and hUMSC–exosomes as therapies for epilepsy. This article provides a brief summary of hUMSCs and hUMSC–exosomes in multiple aspects, such as the isolation and purification method, the mechanism of action, immunological compatibility, tumorigenicity, the risk of transmitting disease, stability upon storage, the potential of new composition with other substances, and also ethical and political issues. We conclude that hUMSCs and hUMSC–exosomes have therapeutic potential for epilepsy, with hUMSC–exosomes being safer due to their reduced immunogenicity. |
| first_indexed | 2024-03-09T19:36:42Z |
| format | Article |
| id | doaj.art-92a956f216074849baadddd00b2cb626 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T19:36:42Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-92a956f216074849baadddd00b2cb6262023-11-24T01:51:49ZengMDPI AGPharmaceuticals1424-82472022-10-011510124710.3390/ph15101247hUMSC vs. hUMSC–Exosome: Which One Is Better for Epilepsy?Sri Hastuti0Rinaldi Idroes1Imran Imran2Yetty Ramli3Abdul Hawil Abas4Trina Ekawati Tallei5Doctoral Program, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDoctoral Program, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, IndonesiaEpilepsy is a disorder characterized by abnormal brain cell activity that results in seizures. It causes progressive damage to neurons. Epilepsy treatment currently focuses mostly on symptoms, which also have risks of unwanted side effects. There is currently no effective treatment to prevent epileptogenesis and the resulting neural damage. Human Umbilical Cord Mesenchymal Stem Cell (hUMSC) and exosome therapy are examples of cellular therapies that may be used to treat degenerative diseases, such as epilepsy, or cell damage. However, there is still little research on the use of hUMSCs or hUMSC–exosomes for treating epilepsy. Hence, the purpose of this paper is to compare the potential and risk of hUMSCs and hUMSC–exosomes as therapies for epilepsy. This article provides a brief summary of hUMSCs and hUMSC–exosomes in multiple aspects, such as the isolation and purification method, the mechanism of action, immunological compatibility, tumorigenicity, the risk of transmitting disease, stability upon storage, the potential of new composition with other substances, and also ethical and political issues. We conclude that hUMSCs and hUMSC–exosomes have therapeutic potential for epilepsy, with hUMSC–exosomes being safer due to their reduced immunogenicity.https://www.mdpi.com/1424-8247/15/10/1247epilepsyhUMSCexosometherapyreview |
| spellingShingle | Sri Hastuti Rinaldi Idroes Imran Imran Yetty Ramli Abdul Hawil Abas Trina Ekawati Tallei hUMSC vs. hUMSC–Exosome: Which One Is Better for Epilepsy? Pharmaceuticals epilepsy hUMSC exosome therapy review |
| title | hUMSC vs. hUMSC–Exosome: Which One Is Better for Epilepsy? |
| title_full | hUMSC vs. hUMSC–Exosome: Which One Is Better for Epilepsy? |
| title_fullStr | hUMSC vs. hUMSC–Exosome: Which One Is Better for Epilepsy? |
| title_full_unstemmed | hUMSC vs. hUMSC–Exosome: Which One Is Better for Epilepsy? |
| title_short | hUMSC vs. hUMSC–Exosome: Which One Is Better for Epilepsy? |
| title_sort | humsc vs humsc exosome which one is better for epilepsy |
| topic | epilepsy hUMSC exosome therapy review |
| url | https://www.mdpi.com/1424-8247/15/10/1247 |
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