Acoustic radiation force impulse imaging for non-invasive assessment of renal histopathology in chronic kidney disease.
OBJECTIVE: To investigate the stiffness values obtained by acoustic radiation force impulse (ARFI) quantification in assessing renal histological fibrosis of chronic kidney disease (CKD). METHODS: 163 patients with CKD and 32 healthy volunteers were enrolled between June 2013 and April 2014. ARFI qu...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4278890?pdf=render |
| _version_ | 1818701081072369664 |
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| author | Qiao Hu Xiao-Yan Wang Hong-Guang He Hai-Ming Wei Li-Ke Kang Gui-Can Qin |
| author_facet | Qiao Hu Xiao-Yan Wang Hong-Guang He Hai-Ming Wei Li-Ke Kang Gui-Can Qin |
| author_sort | Qiao Hu |
| collection | DOAJ |
| description | OBJECTIVE: To investigate the stiffness values obtained by acoustic radiation force impulse (ARFI) quantification in assessing renal histological fibrosis of chronic kidney disease (CKD). METHODS: 163 patients with CKD and 32 healthy volunteers were enrolled between June 2013 and April 2014. ARFI quantification, given as shear wave velocity (SWV), was performed to measure renal parenchyma stiffness. Diagnostic performance of ARFI imaging and conventional ultrasound (US) were compared with histologic scores at renal biopsy. Intra- and inter-observer reliability of SWV measurement was analyzed. RESULTS: In CKD patients, SWV measurements correlated significantly with pathological parameters (r = -0.422--0.511, P<0.001), serum creatinine (r = -0.503, P<0.001), and glomerular filtration rate (r = 0.587, P<0.001). The mean SWV in kidneys with severely impaired (histologic score: ≥19 points) was significant lower than that mildly impaired (histologic score: ≤9 points), moderately impaired (histologic score: 10-18 points), and control groups (all P<0.001). Receiver operating characteristic (ROC) curves analyses indicated that the area under the ROC curve for the diagnosis of renal histological fibrosis using ARFI imaging was superior to these conventional US parameters. Using the optimal cut-off value of 2.65 m/s for the diagnosis of mildly impaired kidneys, 2.50 m/s for moderately impaired kidneys, and 2.33 m/s for severely impaired kidneys, the corresponding area under the ROC curves were 0.735, 0.744, and 0.895, respectively. Intra- and intre-observer agreement of SWV measurements were 0.709 (95% CI: 0.390-0.859, P<0.001) and 0.627 (95% CI: 0.233-0.818, P = 0.004), respectively. CONCLUSIONS: ARFI may be an effective tool for evaluating renal histological fibrosis in CKD patients. |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T15:15:10Z |
| publishDate | 2014-01-01 |
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| series | PLoS ONE |
| spelling | doaj.art-92a95a51b1cf47ef8f3566365e4b55252022-12-21T21:43:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11505110.1371/journal.pone.0115051Acoustic radiation force impulse imaging for non-invasive assessment of renal histopathology in chronic kidney disease.Qiao HuXiao-Yan WangHong-Guang HeHai-Ming WeiLi-Ke KangGui-Can QinOBJECTIVE: To investigate the stiffness values obtained by acoustic radiation force impulse (ARFI) quantification in assessing renal histological fibrosis of chronic kidney disease (CKD). METHODS: 163 patients with CKD and 32 healthy volunteers were enrolled between June 2013 and April 2014. ARFI quantification, given as shear wave velocity (SWV), was performed to measure renal parenchyma stiffness. Diagnostic performance of ARFI imaging and conventional ultrasound (US) were compared with histologic scores at renal biopsy. Intra- and inter-observer reliability of SWV measurement was analyzed. RESULTS: In CKD patients, SWV measurements correlated significantly with pathological parameters (r = -0.422--0.511, P<0.001), serum creatinine (r = -0.503, P<0.001), and glomerular filtration rate (r = 0.587, P<0.001). The mean SWV in kidneys with severely impaired (histologic score: ≥19 points) was significant lower than that mildly impaired (histologic score: ≤9 points), moderately impaired (histologic score: 10-18 points), and control groups (all P<0.001). Receiver operating characteristic (ROC) curves analyses indicated that the area under the ROC curve for the diagnosis of renal histological fibrosis using ARFI imaging was superior to these conventional US parameters. Using the optimal cut-off value of 2.65 m/s for the diagnosis of mildly impaired kidneys, 2.50 m/s for moderately impaired kidneys, and 2.33 m/s for severely impaired kidneys, the corresponding area under the ROC curves were 0.735, 0.744, and 0.895, respectively. Intra- and intre-observer agreement of SWV measurements were 0.709 (95% CI: 0.390-0.859, P<0.001) and 0.627 (95% CI: 0.233-0.818, P = 0.004), respectively. CONCLUSIONS: ARFI may be an effective tool for evaluating renal histological fibrosis in CKD patients.http://europepmc.org/articles/PMC4278890?pdf=render |
| spellingShingle | Qiao Hu Xiao-Yan Wang Hong-Guang He Hai-Ming Wei Li-Ke Kang Gui-Can Qin Acoustic radiation force impulse imaging for non-invasive assessment of renal histopathology in chronic kidney disease. PLoS ONE |
| title | Acoustic radiation force impulse imaging for non-invasive assessment of renal histopathology in chronic kidney disease. |
| title_full | Acoustic radiation force impulse imaging for non-invasive assessment of renal histopathology in chronic kidney disease. |
| title_fullStr | Acoustic radiation force impulse imaging for non-invasive assessment of renal histopathology in chronic kidney disease. |
| title_full_unstemmed | Acoustic radiation force impulse imaging for non-invasive assessment of renal histopathology in chronic kidney disease. |
| title_short | Acoustic radiation force impulse imaging for non-invasive assessment of renal histopathology in chronic kidney disease. |
| title_sort | acoustic radiation force impulse imaging for non invasive assessment of renal histopathology in chronic kidney disease |
| url | http://europepmc.org/articles/PMC4278890?pdf=render |
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