Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System
Abstract The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are associated with superficial mucosal damage and intermittent wounding that leads to epithelial barrier defects and increased permeability. The standard therapeutic interventions for colitis have focus...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202103189 |
| _version_ | 1818322829706264576 |
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| author | Niranjan G. Kotla Isma Liza Mohd Isa Swetha Rasala Secil Demir Rajbir Singh Becca V. Baby Samantha K. Swamy Peter Dockery Venkatakrishna R. Jala Yury Rochev Abhay Pandit |
| author_facet | Niranjan G. Kotla Isma Liza Mohd Isa Swetha Rasala Secil Demir Rajbir Singh Becca V. Baby Samantha K. Swamy Peter Dockery Venkatakrishna R. Jala Yury Rochev Abhay Pandit |
| author_sort | Niranjan G. Kotla |
| collection | DOAJ |
| description | Abstract The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are associated with superficial mucosal damage and intermittent wounding that leads to epithelial barrier defects and increased permeability. The standard therapeutic interventions for colitis have focused mainly on maintaining the remission levels of the disease. Nonetheless, such treatment strategies (using anti‐inflammatory, immunomodulatory agents) do not address colitis' root cause, especially the mucosal damage and dysregulated intestinal barrier functions. Restoration of barrier functionality by mucosal healing or physical barrier protecting strategies shall be considered as an initial event in the disease suppression and progression. Herein, a biphasic hyaluronan (HA) enema suspension, naïve‐HA systems that protect the dysregulated gut epithelium by decreasing the inflammation, permeability, and helping in maintaining the epithelial barrier integrity in the dextran sodium sulfate‐induced colitis mice model is reported. Furthermore, HA‐based system modulates intestinal epithelial junctional proteins and regulatory signaling pathways, resulting in attenuation of inflammation and mucosal protection. The results suggest that HA‐based system can be delivered as an enema to act as a barrier protecting system for managing distal colonic inflammatory diseases, including colitis. |
| first_indexed | 2024-12-13T11:03:01Z |
| format | Article |
| id | doaj.art-92aa1c0cb52b4eafb1c3f8314976d526 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-13T11:03:01Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-92aa1c0cb52b4eafb1c3f8314976d5262022-12-21T23:49:12ZengWileyAdvanced Science2198-38442022-02-0194n/an/a10.1002/advs.202103189Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid SystemNiranjan G. Kotla0Isma Liza Mohd Isa1Swetha Rasala2Secil Demir3Rajbir Singh4Becca V. Baby5Samantha K. Swamy6Peter Dockery7Venkatakrishna R. Jala8Yury Rochev9Abhay Pandit10CÚRAM, SFI Research Centre for Medical Devices National University of Ireland Galway Galway H91 W2TY IrelandCÚRAM, SFI Research Centre for Medical Devices National University of Ireland Galway Galway H91 W2TY IrelandCÚRAM, SFI Research Centre for Medical Devices National University of Ireland Galway Galway H91 W2TY IrelandCÚRAM, SFI Research Centre for Medical Devices National University of Ireland Galway Galway H91 W2TY IrelandDepartment of Microbiology and Immunology James Graham Brown Cancer Center University of Louisville Louisville KY 40202 USADepartment of Microbiology and Immunology James Graham Brown Cancer Center University of Louisville Louisville KY 40202 USACÚRAM, SFI Research Centre for Medical Devices National University of Ireland Galway Galway H91 W2TY IrelandDepartment of Anatomy National University of Ireland Galway H91 TK33 IrelandDepartment of Microbiology and Immunology James Graham Brown Cancer Center University of Louisville Louisville KY 40202 USACÚRAM, SFI Research Centre for Medical Devices National University of Ireland Galway Galway H91 W2TY IrelandCÚRAM, SFI Research Centre for Medical Devices National University of Ireland Galway Galway H91 W2TY IrelandAbstract The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are associated with superficial mucosal damage and intermittent wounding that leads to epithelial barrier defects and increased permeability. The standard therapeutic interventions for colitis have focused mainly on maintaining the remission levels of the disease. Nonetheless, such treatment strategies (using anti‐inflammatory, immunomodulatory agents) do not address colitis' root cause, especially the mucosal damage and dysregulated intestinal barrier functions. Restoration of barrier functionality by mucosal healing or physical barrier protecting strategies shall be considered as an initial event in the disease suppression and progression. Herein, a biphasic hyaluronan (HA) enema suspension, naïve‐HA systems that protect the dysregulated gut epithelium by decreasing the inflammation, permeability, and helping in maintaining the epithelial barrier integrity in the dextran sodium sulfate‐induced colitis mice model is reported. Furthermore, HA‐based system modulates intestinal epithelial junctional proteins and regulatory signaling pathways, resulting in attenuation of inflammation and mucosal protection. The results suggest that HA‐based system can be delivered as an enema to act as a barrier protecting system for managing distal colonic inflammatory diseases, including colitis.https://doi.org/10.1002/advs.202103189dextran sodium sulfate (DSS)‐inducedHAHA systemsinflammatory diseases |
| spellingShingle | Niranjan G. Kotla Isma Liza Mohd Isa Swetha Rasala Secil Demir Rajbir Singh Becca V. Baby Samantha K. Swamy Peter Dockery Venkatakrishna R. Jala Yury Rochev Abhay Pandit Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System Advanced Science dextran sodium sulfate (DSS)‐induced HA HA systems inflammatory diseases |
| title | Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System |
| title_full | Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System |
| title_fullStr | Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System |
| title_full_unstemmed | Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System |
| title_short | Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System |
| title_sort | modulation of gut barrier functions in ulcerative colitis by hyaluronic acid system |
| topic | dextran sodium sulfate (DSS)‐induced HA HA systems inflammatory diseases |
| url | https://doi.org/10.1002/advs.202103189 |
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