Effect of Exercise on Inflamed Psoas Muscle in Women with Obesity: A Pilot Prospective <sup>18</sup>F-FDG PET/CT Study
Obesity increases inflammation in skeletal muscle thereby promoting systemic inflammation which leads to increased risk of cardiometabolic disease. This prospective study aimed to evaluate whether the metabolic activity of psoas muscle (PM) was associated with systemic inflammation, and whether phys...
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MDPI AG
2021-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/2/164 |
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| author | Kisoo Pahk Eung Ju Kim Chanmin Joung Hyun Woo Kwon Hong Seog Seo Sungeun Kim |
| author_facet | Kisoo Pahk Eung Ju Kim Chanmin Joung Hyun Woo Kwon Hong Seog Seo Sungeun Kim |
| author_sort | Kisoo Pahk |
| collection | DOAJ |
| description | Obesity increases inflammation in skeletal muscle thereby promoting systemic inflammation which leads to increased risk of cardiometabolic disease. This prospective study aimed to evaluate whether the metabolic activity of psoas muscle (PM) was associated with systemic inflammation, and whether physical exercise could reduce the PM metabolic activity evaluated by <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in women with obesity. A total of 23 women with obesity who participated in a 3-month physical exercise program were enrolled. <sup>18</sup>F-FDG PET/CT was performed before the start of the program (baseline) and after completion of the program. The maximum standardized uptake value of psoas muscle (PM SUVmax) was used for the PM metabolic activity. The SUVmax of spleen and bone marrow, and the high-sensitivity C-reactive protein were used to evaluate the systemic inflammation. At baseline, PM SUVmax was strongly correlated with the systemic inflammation. The exercise program significantly reduced the PM SUVmax, in addition to adiposity and systemic inflammation. Furthermore, we found that the association between PM SUVmax and the systemic inflammation disappeared after completion of the exercise program. In women with obesity, PM SUVmax, assessed by <sup>18</sup>F-FDG PET/CT, was associated with obesity-induced systemic inflammation and exercise reduced the PM SUVmax and eliminated its association with systemic inflammation. |
| first_indexed | 2024-03-09T03:49:38Z |
| format | Article |
| id | doaj.art-92ac638993a04898856bfc600fc66c0d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T03:49:38Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-92ac638993a04898856bfc600fc66c0d2023-12-03T14:29:17ZengMDPI AGDiagnostics2075-44182021-01-0111216410.3390/diagnostics11020164Effect of Exercise on Inflamed Psoas Muscle in Women with Obesity: A Pilot Prospective <sup>18</sup>F-FDG PET/CT StudyKisoo Pahk0Eung Ju Kim1Chanmin Joung2Hyun Woo Kwon3Hong Seog Seo4Sungeun Kim5Department of Nuclear Medicine, Korea University Anam Hospital, Seoul 02841, KoreaDepartment of Cardiovascular Center, Korea University Guro Hospital, Seoul 08308, KoreaInstitute for Inflammation Control, Korea University, Seoul 02841, KoreaDepartment of Nuclear Medicine, Korea University Anam Hospital, Seoul 02841, KoreaDepartment of Cardiovascular Center, Korea University Guro Hospital, Seoul 08308, KoreaDepartment of Nuclear Medicine, Korea University Anam Hospital, Seoul 02841, KoreaObesity increases inflammation in skeletal muscle thereby promoting systemic inflammation which leads to increased risk of cardiometabolic disease. This prospective study aimed to evaluate whether the metabolic activity of psoas muscle (PM) was associated with systemic inflammation, and whether physical exercise could reduce the PM metabolic activity evaluated by <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in women with obesity. A total of 23 women with obesity who participated in a 3-month physical exercise program were enrolled. <sup>18</sup>F-FDG PET/CT was performed before the start of the program (baseline) and after completion of the program. The maximum standardized uptake value of psoas muscle (PM SUVmax) was used for the PM metabolic activity. The SUVmax of spleen and bone marrow, and the high-sensitivity C-reactive protein were used to evaluate the systemic inflammation. At baseline, PM SUVmax was strongly correlated with the systemic inflammation. The exercise program significantly reduced the PM SUVmax, in addition to adiposity and systemic inflammation. Furthermore, we found that the association between PM SUVmax and the systemic inflammation disappeared after completion of the exercise program. In women with obesity, PM SUVmax, assessed by <sup>18</sup>F-FDG PET/CT, was associated with obesity-induced systemic inflammation and exercise reduced the PM SUVmax and eliminated its association with systemic inflammation.https://www.mdpi.com/2075-4418/11/2/164obesityskeletal musclepsoas muscleinflammationexercisepositron-emission tomography |
| spellingShingle | Kisoo Pahk Eung Ju Kim Chanmin Joung Hyun Woo Kwon Hong Seog Seo Sungeun Kim Effect of Exercise on Inflamed Psoas Muscle in Women with Obesity: A Pilot Prospective <sup>18</sup>F-FDG PET/CT Study Diagnostics obesity skeletal muscle psoas muscle inflammation exercise positron-emission tomography |
| title | Effect of Exercise on Inflamed Psoas Muscle in Women with Obesity: A Pilot Prospective <sup>18</sup>F-FDG PET/CT Study |
| title_full | Effect of Exercise on Inflamed Psoas Muscle in Women with Obesity: A Pilot Prospective <sup>18</sup>F-FDG PET/CT Study |
| title_fullStr | Effect of Exercise on Inflamed Psoas Muscle in Women with Obesity: A Pilot Prospective <sup>18</sup>F-FDG PET/CT Study |
| title_full_unstemmed | Effect of Exercise on Inflamed Psoas Muscle in Women with Obesity: A Pilot Prospective <sup>18</sup>F-FDG PET/CT Study |
| title_short | Effect of Exercise on Inflamed Psoas Muscle in Women with Obesity: A Pilot Prospective <sup>18</sup>F-FDG PET/CT Study |
| title_sort | effect of exercise on inflamed psoas muscle in women with obesity a pilot prospective sup 18 sup f fdg pet ct study |
| topic | obesity skeletal muscle psoas muscle inflammation exercise positron-emission tomography |
| url | https://www.mdpi.com/2075-4418/11/2/164 |
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