Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities
Angiogenesis, a complex, multistep process of forming new blood vessels, plays crucial role in normal development, embryogenesis, and wound healing. Malignant tumors characterized by increased proliferation also require new vasculature to provide an adequate supply of oxygen and nutrients for develo...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/11/6126 |
| _version_ | 1797531173478465536 |
|---|---|
| author | Magdalena Groblewska Barbara Mroczko |
| author_facet | Magdalena Groblewska Barbara Mroczko |
| author_sort | Magdalena Groblewska |
| collection | DOAJ |
| description | Angiogenesis, a complex, multistep process of forming new blood vessels, plays crucial role in normal development, embryogenesis, and wound healing. Malignant tumors characterized by increased proliferation also require new vasculature to provide an adequate supply of oxygen and nutrients for developing tumor. Gliomas are among the most frequent primary tumors of the central nervous system (CNS), characterized by increased new vessel formation. The processes of neoangiogenesis, necessary for glioma development, are mediated by numerous growth factors, cytokines, chemokines and other proteins. In contrast to other solid tumors, some biological conditions, such as the blood–brain barrier and the unique interplay between immune microenvironment and tumor, represent significant challenges in glioma therapy. Therefore, the objective of the study was to present the role of various proangiogenic factors in glioma angiogenesis as well as the differences between normal and tumoral angiogenesis. Another goal was to present novel therapeutic options in oncology approaches. We performed a thorough search via the PubMed database. In this paper we describe various proangiogenic factors in glioma vasculature development. The presented paper also reviews various antiangiogenic factors necessary in maintaining equilibrium between pro- and antiangiogenic processes. Furthermore, we present some novel possibilities of antiangiogenic therapy in this type of tumors. |
| first_indexed | 2024-03-10T10:40:10Z |
| format | Article |
| id | doaj.art-92ace42a6fc74856a957a674a8592973 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:40:10Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-92ace42a6fc74856a957a674a85929732023-11-21T23:02:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012211612610.3390/ijms22116126Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic PossibilitiesMagdalena Groblewska0Barbara Mroczko1Department of Biochemical Diagnostics, University Hospital in Białystok, 15-269 Białystok, PolandDepartment of Biochemical Diagnostics, University Hospital in Białystok, 15-269 Białystok, PolandAngiogenesis, a complex, multistep process of forming new blood vessels, plays crucial role in normal development, embryogenesis, and wound healing. Malignant tumors characterized by increased proliferation also require new vasculature to provide an adequate supply of oxygen and nutrients for developing tumor. Gliomas are among the most frequent primary tumors of the central nervous system (CNS), characterized by increased new vessel formation. The processes of neoangiogenesis, necessary for glioma development, are mediated by numerous growth factors, cytokines, chemokines and other proteins. In contrast to other solid tumors, some biological conditions, such as the blood–brain barrier and the unique interplay between immune microenvironment and tumor, represent significant challenges in glioma therapy. Therefore, the objective of the study was to present the role of various proangiogenic factors in glioma angiogenesis as well as the differences between normal and tumoral angiogenesis. Another goal was to present novel therapeutic options in oncology approaches. We performed a thorough search via the PubMed database. In this paper we describe various proangiogenic factors in glioma vasculature development. The presented paper also reviews various antiangiogenic factors necessary in maintaining equilibrium between pro- and antiangiogenic processes. Furthermore, we present some novel possibilities of antiangiogenic therapy in this type of tumors.https://www.mdpi.com/1422-0067/22/11/6126angiogenesisvasculogenesisangiogenic switchendothelial cellsgliomacentral nervous system tumor |
| spellingShingle | Magdalena Groblewska Barbara Mroczko Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities International Journal of Molecular Sciences angiogenesis vasculogenesis angiogenic switch endothelial cells glioma central nervous system tumor |
| title | Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities |
| title_full | Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities |
| title_fullStr | Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities |
| title_full_unstemmed | Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities |
| title_short | Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities |
| title_sort | pro and antiangiogenic factors in gliomas implications for novel therapeutic possibilities |
| topic | angiogenesis vasculogenesis angiogenic switch endothelial cells glioma central nervous system tumor |
| url | https://www.mdpi.com/1422-0067/22/11/6126 |
| work_keys_str_mv | AT magdalenagroblewska proandantiangiogenicfactorsingliomasimplicationsfornoveltherapeuticpossibilities AT barbaramroczko proandantiangiogenicfactorsingliomasimplicationsfornoveltherapeuticpossibilities |