Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 1
Although cardiac troponins are considered the most specific biomarkers for the diagnosis of acute myocardial infarction (AMI), their diagnostic consideration goes far beyond the detection of this dangerous disease. The mechanisms of cardiac troponin elevation are extremely numerous and not limited t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/9/914 |
| _version_ | 1797518504208891904 |
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| author | Aleksey M. Chaulin |
| author_facet | Aleksey M. Chaulin |
| author_sort | Aleksey M. Chaulin |
| collection | DOAJ |
| description | Although cardiac troponins are considered the most specific biomarkers for the diagnosis of acute myocardial infarction (AMI), their diagnostic consideration goes far beyond the detection of this dangerous disease. The mechanisms of cardiac troponin elevation are extremely numerous and not limited to ischemic necrosis of cardiac myocytes. Practitioners should be well aware of the underlying pathological and physiological conditions that can lead to elevated serum levels of cardiac troponins to avoid differential diagnostic errors, which will be greatly increased if clinicians rely on laboratory data alone. This article presents a classification of the main causes of an elevation in cardiac troponins and discusses in detail the mechanisms of such elevation and the diagnostic consideration of cardiac troponins in some conditions not associated with AMI, such as physical exertion, inflammatory heart diseases (myocarditis and endocarditis), pulmonary embolism (PE), renal failure, and systemic inflammation (sepsis). |
| first_indexed | 2024-03-10T07:30:07Z |
| format | Article |
| id | doaj.art-92afcfb101d049fe90b556022b8351cf |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T07:30:07Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-92afcfb101d049fe90b556022b8351cf2023-11-22T13:55:48ZengMDPI AGLife2075-17292021-09-0111991410.3390/life11090914Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 1Aleksey M. Chaulin0Department of Cardiology and Cardiovascular Surgery, Samara State Medical University, 443099 Samara, RussiaAlthough cardiac troponins are considered the most specific biomarkers for the diagnosis of acute myocardial infarction (AMI), their diagnostic consideration goes far beyond the detection of this dangerous disease. The mechanisms of cardiac troponin elevation are extremely numerous and not limited to ischemic necrosis of cardiac myocytes. Practitioners should be well aware of the underlying pathological and physiological conditions that can lead to elevated serum levels of cardiac troponins to avoid differential diagnostic errors, which will be greatly increased if clinicians rely on laboratory data alone. This article presents a classification of the main causes of an elevation in cardiac troponins and discusses in detail the mechanisms of such elevation and the diagnostic consideration of cardiac troponins in some conditions not associated with AMI, such as physical exertion, inflammatory heart diseases (myocarditis and endocarditis), pulmonary embolism (PE), renal failure, and systemic inflammation (sepsis).https://www.mdpi.com/2075-1729/11/9/914acute myocardial infarctiontroponin Ttroponin Iphysical activitymyocarditisendocarditis |
| spellingShingle | Aleksey M. Chaulin Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 1 Life acute myocardial infarction troponin T troponin I physical activity myocarditis endocarditis |
| title | Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 1 |
| title_full | Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 1 |
| title_fullStr | Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 1 |
| title_full_unstemmed | Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 1 |
| title_short | Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 1 |
| title_sort | elevation mechanisms and diagnostic consideration of cardiac troponins under conditions not associated with myocardial infarction part 1 |
| topic | acute myocardial infarction troponin T troponin I physical activity myocarditis endocarditis |
| url | https://www.mdpi.com/2075-1729/11/9/914 |
| work_keys_str_mv | AT alekseymchaulin elevationmechanismsanddiagnosticconsiderationofcardiactroponinsunderconditionsnotassociatedwithmyocardialinfarctionpart1 |