Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models
Alzheimer’s disease (AD) is an incurable neurodegenerative disorder and the leading cause of death among older individuals. Available treatment strategies only temporarily mitigate symptoms without modifying disease progression. Recent studies revealed the multifaceted neurobiology of AD and shifted...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/5/552 |
| _version_ | 1797501186516975616 |
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| author | Md Fayad Hasan Eugenia Trushina |
| author_facet | Md Fayad Hasan Eugenia Trushina |
| author_sort | Md Fayad Hasan |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is an incurable neurodegenerative disorder and the leading cause of death among older individuals. Available treatment strategies only temporarily mitigate symptoms without modifying disease progression. Recent studies revealed the multifaceted neurobiology of AD and shifted the target of drug development. Established animal models of AD are mostly tailored to yield a subset of disease phenotypes, which do not recapitulate the complexity of sporadic late-onset AD, the most common form of the disease. The use of human induced pluripotent stem cells (HiPSCs) offers unique opportunities to fill these gaps. Emerging technology allows the development of disease models that recapitulate a brain-like microenvironment using patient-derived cells. These models retain the individual’s unraveled genetic background, yielding clinically relevant disease phenotypes and enabling cost-effective, high-throughput studies for drug discovery. Here, we review the development of various HiPSC-based models to study AD mechanisms and their application in drug discovery. |
| first_indexed | 2024-03-10T03:14:45Z |
| format | Article |
| id | doaj.art-92b04fc46f9745239a3834477858f703 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T03:14:45Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-92b04fc46f9745239a3834477858f7032023-11-23T10:16:59ZengMDPI AGBrain Sciences2076-34252022-04-0112555210.3390/brainsci12050552Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro ModelsMd Fayad Hasan0Eugenia Trushina1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USAAlzheimer’s disease (AD) is an incurable neurodegenerative disorder and the leading cause of death among older individuals. Available treatment strategies only temporarily mitigate symptoms without modifying disease progression. Recent studies revealed the multifaceted neurobiology of AD and shifted the target of drug development. Established animal models of AD are mostly tailored to yield a subset of disease phenotypes, which do not recapitulate the complexity of sporadic late-onset AD, the most common form of the disease. The use of human induced pluripotent stem cells (HiPSCs) offers unique opportunities to fill these gaps. Emerging technology allows the development of disease models that recapitulate a brain-like microenvironment using patient-derived cells. These models retain the individual’s unraveled genetic background, yielding clinically relevant disease phenotypes and enabling cost-effective, high-throughput studies for drug discovery. Here, we review the development of various HiPSC-based models to study AD mechanisms and their application in drug discovery.https://www.mdpi.com/2076-3425/12/5/552Alzheimer’s diseasebiofabricationdisease modelinghuman induced pluripotent stem cell (HiPSC)microfluidicsorganoid |
| spellingShingle | Md Fayad Hasan Eugenia Trushina Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models Brain Sciences Alzheimer’s disease biofabrication disease modeling human induced pluripotent stem cell (HiPSC) microfluidics organoid |
| title | Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models |
| title_full | Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models |
| title_fullStr | Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models |
| title_full_unstemmed | Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models |
| title_short | Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models |
| title_sort | advances in recapitulating alzheimer s disease phenotypes using human induced pluripotent stem cell based in vitro models |
| topic | Alzheimer’s disease biofabrication disease modeling human induced pluripotent stem cell (HiPSC) microfluidics organoid |
| url | https://www.mdpi.com/2076-3425/12/5/552 |
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