Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility
The <i>RYK</i> gene encodes a receptor-like tyrosine kinase crucial for several biological processes, including development, tissue homeostasis, and cancer. This study utilized data from the Cancer Genome Atlas Project (TCGA) to evaluate <i>RYK</i> expression at both mRNA and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Molecular Pathology |
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| Online Access: | https://www.mdpi.com/2673-5261/5/1/5 |
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| author | Jessica Alejandra Zapata-García Luis Felipe Jave-Suárez Adriana Aguilar-Lemarroy |
| author_facet | Jessica Alejandra Zapata-García Luis Felipe Jave-Suárez Adriana Aguilar-Lemarroy |
| author_sort | Jessica Alejandra Zapata-García |
| collection | DOAJ |
| description | The <i>RYK</i> gene encodes a receptor-like tyrosine kinase crucial for several biological processes, including development, tissue homeostasis, and cancer. This study utilized data from the Cancer Genome Atlas Project (TCGA) to evaluate <i>RYK</i> expression at both mRNA and protein levels in various cancers, determine its prognostic significance, and explore its involvement in cancer-related signaling pathways. Elevated levels of <i>RYK</i> mRNA were identified in cholangiocarcinoma (CHOL), pancreatic adenocarcinoma (PAAD), glioblastoma multiforme (GBM), lung squamous cell carcinoma (LUSC), brain lower grade glioma (LGG), head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LICH), esophageal carcinoma (ESCA), and colon adenocarcinoma (COAD), while <i>RYK</i> protein levels were observed to be increased in colon adenocarcinoma (COAD), GBM, LICH, cervical and endocervical adenocarcinoma (CESC), and breast invasive carcinoma (BRCA). Additionally, <i>RYK</i> overexpression correlated with poorer prognosis in several cancers, including PAAD, LICH, BRCA, ESCA, COAD, and CESC. Furthermore, <i>RYK</i> showed a positive correlation with the upregulation of multiple receptors and coreceptors in the WNT signaling pathway in various types of cancer. In terms of cancer-related signaling pathways, <i>RYK</i> was found to potentially interact with DNA damage, TSC/mTOR, PI3K/AKT, EMT, RTK, RAS/MAPK, ER hormone, AR hormone, and the cell cycle. This study provides new and previously unreported insights into the role of <i>RYK</i> in cancer biology. |
| first_indexed | 2024-04-24T18:08:15Z |
| format | Article |
| id | doaj.art-92b17cc4aace42589bd087ec5df33647 |
| institution | Directory Open Access Journal |
| issn | 2673-5261 |
| language | English |
| last_indexed | 2024-04-24T18:08:15Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Molecular Pathology |
| spelling | doaj.art-92b17cc4aace42589bd087ec5df336472024-03-27T13:49:02ZengMDPI AGJournal of Molecular Pathology2673-52612024-02-0151668010.3390/jmp5010005Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic UtilityJessica Alejandra Zapata-García0Luis Felipe Jave-Suárez1Adriana Aguilar-Lemarroy2Facultad de Medicina, Decanato de Ciencias de la Salud, Universidad Autónoma de Guadalajara Zapopan, Zapopan 45129, MexicoDivisión de Inmunología, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara C.P. 44340, MexicoDivisión de Inmunología, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara C.P. 44340, MexicoThe <i>RYK</i> gene encodes a receptor-like tyrosine kinase crucial for several biological processes, including development, tissue homeostasis, and cancer. This study utilized data from the Cancer Genome Atlas Project (TCGA) to evaluate <i>RYK</i> expression at both mRNA and protein levels in various cancers, determine its prognostic significance, and explore its involvement in cancer-related signaling pathways. Elevated levels of <i>RYK</i> mRNA were identified in cholangiocarcinoma (CHOL), pancreatic adenocarcinoma (PAAD), glioblastoma multiforme (GBM), lung squamous cell carcinoma (LUSC), brain lower grade glioma (LGG), head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LICH), esophageal carcinoma (ESCA), and colon adenocarcinoma (COAD), while <i>RYK</i> protein levels were observed to be increased in colon adenocarcinoma (COAD), GBM, LICH, cervical and endocervical adenocarcinoma (CESC), and breast invasive carcinoma (BRCA). Additionally, <i>RYK</i> overexpression correlated with poorer prognosis in several cancers, including PAAD, LICH, BRCA, ESCA, COAD, and CESC. Furthermore, <i>RYK</i> showed a positive correlation with the upregulation of multiple receptors and coreceptors in the WNT signaling pathway in various types of cancer. In terms of cancer-related signaling pathways, <i>RYK</i> was found to potentially interact with DNA damage, TSC/mTOR, PI3K/AKT, EMT, RTK, RAS/MAPK, ER hormone, AR hormone, and the cell cycle. This study provides new and previously unreported insights into the role of <i>RYK</i> in cancer biology.https://www.mdpi.com/2673-5261/5/1/5receptor-like tyrosine kinase<i>RYK</i>diagnosticprognosticcancerWNT pathways |
| spellingShingle | Jessica Alejandra Zapata-García Luis Felipe Jave-Suárez Adriana Aguilar-Lemarroy Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility Journal of Molecular Pathology receptor-like tyrosine kinase <i>RYK</i> diagnostic prognostic cancer WNT pathways |
| title | Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility |
| title_full | Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility |
| title_fullStr | Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility |
| title_full_unstemmed | Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility |
| title_short | Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility |
| title_sort | delving into the role of receptor like tyrosine kinase ryk in cancer in silico insights into its diagnostic and prognostic utility |
| topic | receptor-like tyrosine kinase <i>RYK</i> diagnostic prognostic cancer WNT pathways |
| url | https://www.mdpi.com/2673-5261/5/1/5 |
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