Surface modification of Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for enhanced biocompatibility in implant applications
This study focuses on the design of a new Ti based multicomponent amorphous alloy for the development of biocompatible implant materials with enhanced hemocompatibility and cytocompatibility. While this class of amorphous alloys has shown its potential for biomedical implant applications, there are...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785424007543 |
| _version_ | 1827216683437129728 |
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| author | Kirti Tiwari Andreu Blanquer Cristina Pavan Maura Tomatis Nora Fernandez Navas Federico Scaglione Gianluca Fiore Francesco Turci Carme Nogués Paola Rizzi |
| author_facet | Kirti Tiwari Andreu Blanquer Cristina Pavan Maura Tomatis Nora Fernandez Navas Federico Scaglione Gianluca Fiore Francesco Turci Carme Nogués Paola Rizzi |
| author_sort | Kirti Tiwari |
| collection | DOAJ |
| description | This study focuses on the design of a new Ti based multicomponent amorphous alloy for the development of biocompatible implant materials with enhanced hemocompatibility and cytocompatibility. While this class of amorphous alloys has shown its potential for biomedical implant applications, there are major concerns due to the presence of elements such as copper which can lead to cytotoxicity in the human body during long term implantation. Nevertheless, copper is indispensable in the development of an amorphous alloy. Thus, the objective of this work is to selectively remove copper from the surface of the Ti40Cu40Zr11Fe3Sn3Ag3 (at%) amorphous alloy using the dealloying technique and produce a patterned protective passivated surface rich in Ti and Zr oxides. Nitric acid (HNO3) has been found to be effective in depleting copper from the sample surface. Optimization of treatment parameters such as temperature (70 °C and room temperature) yielded drastic differences in the morphology of the samples studied using Field-Emission Scanning Electron Microscopy. The treated sample surface demonstrated good hemocompatibility and cytocompatibility with primary human osteoblast cells (HOb) and human osteosarcoma cell line (Saos-2). Additionally, the treated samples showed higher ability to produce reactive oxygen species with respect to pristine samples, which could be convenient for preserving the implant from bacterial contamination. These findings contribute to the advancement of producing copper-depleted nanostructured Ti based amorphous alloys for biomedical implant applications. |
| first_indexed | 2024-04-24T12:51:17Z |
| format | Article |
| id | doaj.art-92b17fc4c9f64d79bcb508f18cde4c98 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2025-03-21T15:07:01Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-92b17fc4c9f64d79bcb508f18cde4c982024-06-20T06:53:09ZengElsevierJournal of Materials Research and Technology2238-78542024-05-013023332346Surface modification of Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for enhanced biocompatibility in implant applicationsKirti Tiwari0Andreu Blanquer1Cristina Pavan2Maura Tomatis3Nora Fernandez Navas4Federico Scaglione5Gianluca Fiore6Francesco Turci7Carme Nogués8Paola Rizzi9Department of Chemistry and NIS, Università degli Studi di Torino, 10125, Torino, ItalyDepartament de Biologia Cel·lular, Fisiologia i Immunologia Universitat Autònoma de Barcelona Edifici C, 08193, Bellaterra, SpainDepartment of Chemistry, “G. Scansetti” Interdepartmental Centre for Studies on Asbestos and Other Toxic Particulates, Università degli Studi di Torino, 10125, Torino, Italy; Louvain Centre for Toxicology and Applied Pharmacology, Institute of Experimental and Clinical Research, Université catholique de Louvain, 1200, Brussels, Belgium; Corresponding author. Department of Chemistry, “G. Scansetti” Interdepartmental Centre for Studies on Asbestos and Other Toxic Particulates, Università degli Studi di Torino, 10125, Torino, Italy.Department of Chemistry, “G. Scansetti” Interdepartmental Centre for Studies on Asbestos and Other Toxic Particulates, Università degli Studi di Torino, 10125, Torino, Italy; Department of Veterinary Sciences, Università degli Studi di Torino, 10095, Grugliasco, ItalyLeibniz Institute for Solid State and Materials Research Dresden (Leibniz IFW Dresden), 01069, Dresden, Germany; Faculty of Mechanical Science and Engineering, TU Dresden, 01069, Dresden, GermanyDepartment of Chemistry and NIS, Università degli Studi di Torino, 10125, Torino, ItalyDepartment of Chemistry and NIS, Università degli Studi di Torino, 10125, Torino, ItalyDepartment of Chemistry, “G. Scansetti” Interdepartmental Centre for Studies on Asbestos and Other Toxic Particulates, Università degli Studi di Torino, 10125, Torino, ItalyDepartament de Biologia Cel·lular, Fisiologia i Immunologia Universitat Autònoma de Barcelona Edifici C, 08193, Bellaterra, Spain; Corresponding author.Department of Chemistry and NIS, Università degli Studi di Torino, 10125, Torino, ItalyThis study focuses on the design of a new Ti based multicomponent amorphous alloy for the development of biocompatible implant materials with enhanced hemocompatibility and cytocompatibility. While this class of amorphous alloys has shown its potential for biomedical implant applications, there are major concerns due to the presence of elements such as copper which can lead to cytotoxicity in the human body during long term implantation. Nevertheless, copper is indispensable in the development of an amorphous alloy. Thus, the objective of this work is to selectively remove copper from the surface of the Ti40Cu40Zr11Fe3Sn3Ag3 (at%) amorphous alloy using the dealloying technique and produce a patterned protective passivated surface rich in Ti and Zr oxides. Nitric acid (HNO3) has been found to be effective in depleting copper from the sample surface. Optimization of treatment parameters such as temperature (70 °C and room temperature) yielded drastic differences in the morphology of the samples studied using Field-Emission Scanning Electron Microscopy. The treated sample surface demonstrated good hemocompatibility and cytocompatibility with primary human osteoblast cells (HOb) and human osteosarcoma cell line (Saos-2). Additionally, the treated samples showed higher ability to produce reactive oxygen species with respect to pristine samples, which could be convenient for preserving the implant from bacterial contamination. These findings contribute to the advancement of producing copper-depleted nanostructured Ti based amorphous alloys for biomedical implant applications.http://www.sciencedirect.com/science/article/pii/S2238785424007543Amorphous alloyBiomedical implantTi based alloyDealloyingHemocompatibilityBiocompatibility |
| spellingShingle | Kirti Tiwari Andreu Blanquer Cristina Pavan Maura Tomatis Nora Fernandez Navas Federico Scaglione Gianluca Fiore Francesco Turci Carme Nogués Paola Rizzi Surface modification of Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for enhanced biocompatibility in implant applications Journal of Materials Research and Technology Amorphous alloy Biomedical implant Ti based alloy Dealloying Hemocompatibility Biocompatibility |
| title | Surface modification of Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for enhanced biocompatibility in implant applications |
| title_full | Surface modification of Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for enhanced biocompatibility in implant applications |
| title_fullStr | Surface modification of Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for enhanced biocompatibility in implant applications |
| title_full_unstemmed | Surface modification of Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for enhanced biocompatibility in implant applications |
| title_short | Surface modification of Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for enhanced biocompatibility in implant applications |
| title_sort | surface modification of ti40cu40zr11fe3sn3ag3 amorphous alloy for enhanced biocompatibility in implant applications |
| topic | Amorphous alloy Biomedical implant Ti based alloy Dealloying Hemocompatibility Biocompatibility |
| url | http://www.sciencedirect.com/science/article/pii/S2238785424007543 |
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