Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice
Objectives: Swas Kas Chintamani Ras (SKC) is an ayurvedic preparation indicated for respiratory diseases. Our study was aimed to determine the psychopharmacological and neurosafety profile of SKC. Materials and Methods: Psychopharmacological effects and neurosafety profile of this drug were determin...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2017-12-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/article_9536_4041f1a872e8e4e92fdf675c68663c30.pdf |
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| author | Tarequl Islam MD. Saddam Hussain Mohammad Nurul Amin Ashraful Mahmud Tuhin |
| author_facet | Tarequl Islam MD. Saddam Hussain Mohammad Nurul Amin Ashraful Mahmud Tuhin |
| author_sort | Tarequl Islam |
| collection | DOAJ |
| description | Objectives: Swas Kas Chintamani Ras (SKC) is an ayurvedic preparation indicated for respiratory diseases. Our study was aimed to determine the psychopharmacological and neurosafety profile of SKC. Materials and Methods: Psychopharmacological effects and neurosafety profile of this drug were determined by nine complementary test methods namely, open field, locomotor activity, hole cross, hole board test, elevated plus maze, staircase, forced swimming test, and rotarod test. Male mice (Swiss-Webster strain, 20-40 g body weight) bred in the Animal House of the Department of Pharmacy, Jahangirnagar University, were used for the pharmacological experiments. Results: The drug decreased total ambulation and movement in the central region and standing up behavior and lowered emotional defecation. The drug also made the mice to take a shorter time to come out of the cage. Also, animals spent less time in open arm and the movement in the closed arm and locomotors reduced (p=0.003), where a number of rearing (p=0.04) behaviour indicating possible anxiolytic activity. Also, no signs of anti-depressant activity were observed among SKC-treated group. Conclusion: We concluded that our drug showed no neurotoxic effect and it also showed some beneficial neuropharmacological properties. |
| first_indexed | 2024-12-11T10:09:21Z |
| format | Article |
| id | doaj.art-92b308654a68449fb3ef54fe84ed4570 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-11T10:09:21Z |
| publishDate | 2017-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-92b308654a68449fb3ef54fe84ed45702022-12-22T01:11:49ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492017-12-0181859510.22038/ajp.2017.20300.17879536Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster miceTarequl Islam0MD. Saddam Hussain1Mohammad Nurul Amin2Ashraful Mahmud Tuhin3Department of microbiology, Noakhali Science and Technology University, Sonapur-3814, Noakhali, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali-3814,BangladeshDepartment of pharmacy, Atish Dipankar University of Science and Technology, Banani, Dhaka, BangladeshDepartment of pharmacy, Noakhali Science and Technology University, Sonapur-3814, Noakhali, BangladeshObjectives: Swas Kas Chintamani Ras (SKC) is an ayurvedic preparation indicated for respiratory diseases. Our study was aimed to determine the psychopharmacological and neurosafety profile of SKC. Materials and Methods: Psychopharmacological effects and neurosafety profile of this drug were determined by nine complementary test methods namely, open field, locomotor activity, hole cross, hole board test, elevated plus maze, staircase, forced swimming test, and rotarod test. Male mice (Swiss-Webster strain, 20-40 g body weight) bred in the Animal House of the Department of Pharmacy, Jahangirnagar University, were used for the pharmacological experiments. Results: The drug decreased total ambulation and movement in the central region and standing up behavior and lowered emotional defecation. The drug also made the mice to take a shorter time to come out of the cage. Also, animals spent less time in open arm and the movement in the closed arm and locomotors reduced (p=0.003), where a number of rearing (p=0.04) behaviour indicating possible anxiolytic activity. Also, no signs of anti-depressant activity were observed among SKC-treated group. Conclusion: We concluded that our drug showed no neurotoxic effect and it also showed some beneficial neuropharmacological properties.http://ajp.mums.ac.ir/article_9536_4041f1a872e8e4e92fdf675c68663c30.pdfSKCPsychopharmacologicalNeurosafetyNumber of rearing |
| spellingShingle | Tarequl Islam MD. Saddam Hussain Mohammad Nurul Amin Ashraful Mahmud Tuhin Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice Avicenna Journal of Phytomedicine SKC Psychopharmacological Neurosafety Number of rearing |
| title | Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice |
| title_full | Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice |
| title_fullStr | Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice |
| title_full_unstemmed | Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice |
| title_short | Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice |
| title_sort | evaluation of psychopharmacological and neurosafety profile of swas kas chintamani ras skc in swiss webster mice |
| topic | SKC Psychopharmacological Neurosafety Number of rearing |
| url | http://ajp.mums.ac.ir/article_9536_4041f1a872e8e4e92fdf675c68663c30.pdf |
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