MitoEVs: A new player in multiple disease pathology and treatment
Abstract Mitochondrial damage plays vital roles in the pathology of many diseases, such as cancers, neurodegenerative diseases, aging, metabolic diseases and many types of organ injury. However, the regulatory mechanism of mitochondrial functions among different cells or organs in vivo is still uncl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
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| Series: | Journal of Extracellular Vesicles |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jev2.12320 |
| _version_ | 1797840549972017152 |
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| author | Xiyue Zhou Shuyun Liu Yanrong Lu Meihua Wan Jingqiu Cheng Jingping Liu |
| author_facet | Xiyue Zhou Shuyun Liu Yanrong Lu Meihua Wan Jingqiu Cheng Jingping Liu |
| author_sort | Xiyue Zhou |
| collection | DOAJ |
| description | Abstract Mitochondrial damage plays vital roles in the pathology of many diseases, such as cancers, neurodegenerative diseases, aging, metabolic diseases and many types of organ injury. However, the regulatory mechanism of mitochondrial functions among different cells or organs in vivo is still unclear, and efficient therapies for attenuating mitochondrial damage are urgently needed. Extracellular vesicles (EVs) are cell‐derived nanovesicles that can deliver bioactive cargoes among cells or organs. Interestingly, recent evidence shows that diverse mitochondrial contents are enriched in certain EV subpopulations, and such mitoEVs can deliver mitochondrial components to affect the functions of recipient cells under different conditions, which has emerged as a hot topic in this field. However, the overview and many essential questions with respect to this event remain elusive. In this review, we provide a global view of mitoEVs biology and mainly focus on the detailed sorting mechanisms, functional mitochondrial contents, and diverse biological effects of mitoEVs. We also discuss the pathogenic or therapeutic roles of mitoEVs in different diseases and highlight their potential as disease biomarkers or therapies in clinical translation. This review will provide insights into the pathology and drug development for various mitochondrial injury‐related diseases. |
| first_indexed | 2024-04-09T16:17:10Z |
| format | Article |
| id | doaj.art-92b381bb048c4abf960713606c4c5e3c |
| institution | Directory Open Access Journal |
| issn | 2001-3078 |
| language | English |
| last_indexed | 2024-04-09T16:17:10Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Extracellular Vesicles |
| spelling | doaj.art-92b381bb048c4abf960713606c4c5e3c2023-04-24T03:44:33ZengWileyJournal of Extracellular Vesicles2001-30782023-04-01124n/an/a10.1002/jev2.12320MitoEVs: A new player in multiple disease pathology and treatmentXiyue Zhou0Shuyun Liu1Yanrong Lu2Meihua Wan3Jingqiu Cheng4Jingping Liu5NHC Key Laboratory of Transplant Engineering and Immunology Frontiers Science Center for Disease‐related Molecular Network West China Hospital, Sichuan University Chengdu ChinaNHC Key Laboratory of Transplant Engineering and Immunology Frontiers Science Center for Disease‐related Molecular Network West China Hospital, Sichuan University Chengdu ChinaNHC Key Laboratory of Transplant Engineering and Immunology Frontiers Science Center for Disease‐related Molecular Network West China Hospital, Sichuan University Chengdu ChinaDepartment of Integrated Traditional Chinese and Western Medicine West China Hospital, Sichuan University Chengdu ChinaNHC Key Laboratory of Transplant Engineering and Immunology Frontiers Science Center for Disease‐related Molecular Network West China Hospital, Sichuan University Chengdu ChinaNHC Key Laboratory of Transplant Engineering and Immunology Frontiers Science Center for Disease‐related Molecular Network West China Hospital, Sichuan University Chengdu ChinaAbstract Mitochondrial damage plays vital roles in the pathology of many diseases, such as cancers, neurodegenerative diseases, aging, metabolic diseases and many types of organ injury. However, the regulatory mechanism of mitochondrial functions among different cells or organs in vivo is still unclear, and efficient therapies for attenuating mitochondrial damage are urgently needed. Extracellular vesicles (EVs) are cell‐derived nanovesicles that can deliver bioactive cargoes among cells or organs. Interestingly, recent evidence shows that diverse mitochondrial contents are enriched in certain EV subpopulations, and such mitoEVs can deliver mitochondrial components to affect the functions of recipient cells under different conditions, which has emerged as a hot topic in this field. However, the overview and many essential questions with respect to this event remain elusive. In this review, we provide a global view of mitoEVs biology and mainly focus on the detailed sorting mechanisms, functional mitochondrial contents, and diverse biological effects of mitoEVs. We also discuss the pathogenic or therapeutic roles of mitoEVs in different diseases and highlight their potential as disease biomarkers or therapies in clinical translation. This review will provide insights into the pathology and drug development for various mitochondrial injury‐related diseases.https://doi.org/10.1002/jev2.12320extracellular vesicleimmune responsemetabolismmitochondriamitoEV |
| spellingShingle | Xiyue Zhou Shuyun Liu Yanrong Lu Meihua Wan Jingqiu Cheng Jingping Liu MitoEVs: A new player in multiple disease pathology and treatment Journal of Extracellular Vesicles extracellular vesicle immune response metabolism mitochondria mitoEV |
| title | MitoEVs: A new player in multiple disease pathology and treatment |
| title_full | MitoEVs: A new player in multiple disease pathology and treatment |
| title_fullStr | MitoEVs: A new player in multiple disease pathology and treatment |
| title_full_unstemmed | MitoEVs: A new player in multiple disease pathology and treatment |
| title_short | MitoEVs: A new player in multiple disease pathology and treatment |
| title_sort | mitoevs a new player in multiple disease pathology and treatment |
| topic | extracellular vesicle immune response metabolism mitochondria mitoEV |
| url | https://doi.org/10.1002/jev2.12320 |
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