Roles of Conceptus Secretory Proteins in Establishment and Maintenance of Pregnancy in Ruminants
Reproduction in ruminant species is a highly complex biological process requiring a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling and re...
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| Format: | Article |
| Language: | English |
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Asian-Australasian Association of Animal Production Societies
2012-01-01
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| Series: | Asian-Australasian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | http://www.ajas.info/upload/pdf/25-1.pdf |
| _version_ | 1818065063283523584 |
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| author | Fuller W. Bazer Gwonhwa Song William W. Thatcher |
| author_facet | Fuller W. Bazer Gwonhwa Song William W. Thatcher |
| author_sort | Fuller W. Bazer |
| collection | DOAJ |
| description | Reproduction in ruminant species is a highly complex biological process requiring a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling and regulation of gene expression by uterine epithelial and stromal cells. The uterus provide a microenvironment in which molecules secreted by uterine epithelia and transported into the uterine lumen represent histotroph, also known as the secretome, that are required for growth and development of the conceptus and receptivity of the uterus to implantation by the elongating conceptus. Pregnancy recognition signaling as related to sustaining the functional lifespan of the corpora lutea, is required to sustain the functional life-span of corpora lutea for production of progesterone which is essential for uterine functions supportive of implantation and placentation required for successful outcomes of pregnancy. It is within the peri-implantation period that most embryonic deaths occur in ruminants due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. The endocrine status of the pregnant ruminant and her nutritional status are critical for successful establishment and maintenance of pregnancy. The challenge is to understand the complexity of key mechanisms that are characteristic of successful reproduction in humans and animals and to use that knowledge to enhance fertility and reproductive health of ruminant species in livestock enterprises. |
| first_indexed | 2024-12-10T14:45:56Z |
| format | Article |
| id | doaj.art-92b5c044556d40b490ada7d4c1930a4c |
| institution | Directory Open Access Journal |
| issn | 1011-2367 1976-5517 |
| language | English |
| last_indexed | 2024-12-10T14:45:56Z |
| publishDate | 2012-01-01 |
| publisher | Asian-Australasian Association of Animal Production Societies |
| record_format | Article |
| series | Asian-Australasian Journal of Animal Sciences |
| spelling | doaj.art-92b5c044556d40b490ada7d4c1930a4c2022-12-22T01:44:34ZengAsian-Australasian Association of Animal Production SocietiesAsian-Australasian Journal of Animal Sciences1011-23671976-55172012-01-0125111610.5713/ajas.2011.r.0822644Roles of Conceptus Secretory Proteins in Establishment and Maintenance of Pregnancy in RuminantsFuller W. Bazer0Gwonhwa Song1William W. Thatcher2 Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A&M University, College Station, Texas 77843-2471, USA WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-921, .Korea Department of Animal Sciences, University of Florida, Gainesville, Florida 32611-0691, .USAReproduction in ruminant species is a highly complex biological process requiring a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling and regulation of gene expression by uterine epithelial and stromal cells. The uterus provide a microenvironment in which molecules secreted by uterine epithelia and transported into the uterine lumen represent histotroph, also known as the secretome, that are required for growth and development of the conceptus and receptivity of the uterus to implantation by the elongating conceptus. Pregnancy recognition signaling as related to sustaining the functional lifespan of the corpora lutea, is required to sustain the functional life-span of corpora lutea for production of progesterone which is essential for uterine functions supportive of implantation and placentation required for successful outcomes of pregnancy. It is within the peri-implantation period that most embryonic deaths occur in ruminants due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. The endocrine status of the pregnant ruminant and her nutritional status are critical for successful establishment and maintenance of pregnancy. The challenge is to understand the complexity of key mechanisms that are characteristic of successful reproduction in humans and animals and to use that knowledge to enhance fertility and reproductive health of ruminant species in livestock enterprises.http://www.ajas.info/upload/pdf/25-1.pdfUterusInterferon TauPregnancyNutritionImplantationGene Expression |
| spellingShingle | Fuller W. Bazer Gwonhwa Song William W. Thatcher Roles of Conceptus Secretory Proteins in Establishment and Maintenance of Pregnancy in Ruminants Asian-Australasian Journal of Animal Sciences Uterus Interferon Tau Pregnancy Nutrition Implantation Gene Expression |
| title | Roles of Conceptus Secretory Proteins in Establishment and Maintenance of Pregnancy in Ruminants |
| title_full | Roles of Conceptus Secretory Proteins in Establishment and Maintenance of Pregnancy in Ruminants |
| title_fullStr | Roles of Conceptus Secretory Proteins in Establishment and Maintenance of Pregnancy in Ruminants |
| title_full_unstemmed | Roles of Conceptus Secretory Proteins in Establishment and Maintenance of Pregnancy in Ruminants |
| title_short | Roles of Conceptus Secretory Proteins in Establishment and Maintenance of Pregnancy in Ruminants |
| title_sort | roles of conceptus secretory proteins in establishment and maintenance of pregnancy in ruminants |
| topic | Uterus Interferon Tau Pregnancy Nutrition Implantation Gene Expression |
| url | http://www.ajas.info/upload/pdf/25-1.pdf |
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