Foveal morphology affects self-perceived visual function and treatment response in neovascular age-related macular degeneration: a cohort study.
OBJECTIVES: To investigate the relationship between foveal morphology and self-perceived visual function in patients with neovascular age-related macular degeneration (AMD) and whether foveal characteristics are associated with Ranibizumab treatment response on the self-perceived visual function. ME...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3949984?pdf=render |
| _version_ | 1819274234072924160 |
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| author | Yousif Subhi Gitte Ø Henningsen Charlotte T Larsen Mette S Sørensen Torben L Sørensen |
| author_facet | Yousif Subhi Gitte Ø Henningsen Charlotte T Larsen Mette S Sørensen Torben L Sørensen |
| author_sort | Yousif Subhi |
| collection | DOAJ |
| description | OBJECTIVES: To investigate the relationship between foveal morphology and self-perceived visual function in patients with neovascular age-related macular degeneration (AMD) and whether foveal characteristics are associated with Ranibizumab treatment response on the self-perceived visual function. METHODS: This prospective cohort study included patients with newly diagnosed neovascular AMD found eligible for treatment with Ranibizumab. Foveal morphology of both eyes was assessed using spectral-domain optical coherence tomography and all patients were interviewed using the 39-item National Eye Institute Visual Function Questionnaire (VFQ). Patients were re-interviewed 3 and 12 months after initiation of treatment with Ranibizumab. We evaluated foveal morphology at baseline in relation to VFQ scores at baseline and clinically meaningful changes in VFQ after 3 and 12 months. RESULTS: VFQ scores correlated with central foveal thickness, central foveal thickness of neuroretina (CFN), foveal RPE elevation, foveal integrity of the photoreceptor inner segment/outer segment junction (IS/OS), and external limiting membrane. In a multiple linear regression model, only best-corrected visual acuity of the better eye (p<0.001) and the IS/OS status in the better eye (p = 0.012) remained significant (Adjusted R(2) = 0.418). Lower baseline VFQ and a baseline CFN within 170-270 µm in the better eye were both associated with a clinically meaningful increase in the VFQ scores after 3 and 12 months. An absent foveal IS/OS band in the better eye was associated with a clinically meaningful decrease in the VFQ scores at 12 months. CONCLUSIONS: Foveal morphology in the better eye influences the self-perceived visual function in patients with neovascular AMD and possesses a predictive value for change in the self-perceived visual function at 3 and 12 months after initiation of treatment. These findings may help clinicians provide patients more individualized information of their disease and treatment prognosis from a patient-perceived point-of-view. |
| first_indexed | 2024-12-23T23:05:11Z |
| format | Article |
| id | doaj.art-92b5ea81d5364b4e82f8bea28b83e143 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T23:05:11Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-92b5ea81d5364b4e82f8bea28b83e1432022-12-21T17:26:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9122710.1371/journal.pone.0091227Foveal morphology affects self-perceived visual function and treatment response in neovascular age-related macular degeneration: a cohort study.Yousif SubhiGitte Ø HenningsenCharlotte T LarsenMette S SørensenTorben L SørensenOBJECTIVES: To investigate the relationship between foveal morphology and self-perceived visual function in patients with neovascular age-related macular degeneration (AMD) and whether foveal characteristics are associated with Ranibizumab treatment response on the self-perceived visual function. METHODS: This prospective cohort study included patients with newly diagnosed neovascular AMD found eligible for treatment with Ranibizumab. Foveal morphology of both eyes was assessed using spectral-domain optical coherence tomography and all patients were interviewed using the 39-item National Eye Institute Visual Function Questionnaire (VFQ). Patients were re-interviewed 3 and 12 months after initiation of treatment with Ranibizumab. We evaluated foveal morphology at baseline in relation to VFQ scores at baseline and clinically meaningful changes in VFQ after 3 and 12 months. RESULTS: VFQ scores correlated with central foveal thickness, central foveal thickness of neuroretina (CFN), foveal RPE elevation, foveal integrity of the photoreceptor inner segment/outer segment junction (IS/OS), and external limiting membrane. In a multiple linear regression model, only best-corrected visual acuity of the better eye (p<0.001) and the IS/OS status in the better eye (p = 0.012) remained significant (Adjusted R(2) = 0.418). Lower baseline VFQ and a baseline CFN within 170-270 µm in the better eye were both associated with a clinically meaningful increase in the VFQ scores after 3 and 12 months. An absent foveal IS/OS band in the better eye was associated with a clinically meaningful decrease in the VFQ scores at 12 months. CONCLUSIONS: Foveal morphology in the better eye influences the self-perceived visual function in patients with neovascular AMD and possesses a predictive value for change in the self-perceived visual function at 3 and 12 months after initiation of treatment. These findings may help clinicians provide patients more individualized information of their disease and treatment prognosis from a patient-perceived point-of-view.http://europepmc.org/articles/PMC3949984?pdf=render |
| spellingShingle | Yousif Subhi Gitte Ø Henningsen Charlotte T Larsen Mette S Sørensen Torben L Sørensen Foveal morphology affects self-perceived visual function and treatment response in neovascular age-related macular degeneration: a cohort study. PLoS ONE |
| title | Foveal morphology affects self-perceived visual function and treatment response in neovascular age-related macular degeneration: a cohort study. |
| title_full | Foveal morphology affects self-perceived visual function and treatment response in neovascular age-related macular degeneration: a cohort study. |
| title_fullStr | Foveal morphology affects self-perceived visual function and treatment response in neovascular age-related macular degeneration: a cohort study. |
| title_full_unstemmed | Foveal morphology affects self-perceived visual function and treatment response in neovascular age-related macular degeneration: a cohort study. |
| title_short | Foveal morphology affects self-perceived visual function and treatment response in neovascular age-related macular degeneration: a cohort study. |
| title_sort | foveal morphology affects self perceived visual function and treatment response in neovascular age related macular degeneration a cohort study |
| url | http://europepmc.org/articles/PMC3949984?pdf=render |
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